Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Operator's license - revocations and suspensions
, 1958 by Edward M. Syring, Manager, Drivers' License Division.Address before the Sixth Oregon Traffic Court Conference, University of Oregon, Eugene, April 24, 1958.Title from PDF caption (viewed on August 3, 2022).This archived document is maintained by the ...
core
Value drivers of development stage biopharma companies. [PDF]
Eur J Health Econ, 2022 Michaeli DT +3 more
europepmc +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Evaluation of hearing status of Yazd railway\'s train drivers in 2011 [PDF]
طب کار, 2013 Background: Noise-induced hearing loss is a sensorineural hearing loss, which is associated with exposure to high levels of sound. Since train drivers exposed to high noise levels and the use of hearing protection devices is relatively difficult and they
Z Loukzadeh +3 more
doaj
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Executive Functions and Risk Propensity in Adolescent and Adult Male Drivers: A Comparison [PDF]
, 2010 Young drivers between the ages of 16 and 24 are over-represented in motor-vehicle accident statistics worldwide. Several studies suggest that age could be a major crash risk factor in young drivers because their frontal lobes are not yet fully developed.
Moleni, James
core
Drivers of Housing Demolition Decision Making and the Impact on Timber Waste Management
Construction Economics and Building, 2011 The study investigates housing demolition and timber waste recovery – with the aim to identify ways of improving recovery. Using case studies the research focused on demolisher decision making, their onsite processes and the associated network of ...
Perry John Forsythe
doaj +1 more source
Value drivers for pharmaceutical products in health technology assessment (HTA) in Saudi Arabia: Results from a capacity Building, Multi-Stakeholder workshop. [PDF]
Saudi Pharm J, 2021 Al-Omar HA +2 more
europepmc +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source