Results 121 to 130 of about 14,679,274 (316)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Towards standardization of Prakriti Evaluation: A scoping review of modern assessment tools and their psychometric properties in Ayurvedic medicine

Journal of Ayurveda and Integrative Medicine
Background: Ayurveda is an ancient Indian medical system that emphasizes individualized care based on the concept of Prakriti, which represents an individual's relative proportion of three doshas (humour) at the time of conception.
Ankit Gupta, Varsha Singh, Sushil Chandra, Rahul Garg   +3 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Values, ethics and empowering the self through cooperative education [PDF]

, 2011
Following the recent global financial crisis and the collapse of major organisations such as Lehman Brothers, and the earlier corporate failings of Enron and HIH, there has been a shift of focus towards the role of ethics education in the formation of ...
Campbell, Matthew, E. Zegwaard, Karsten, Zegwaard, Karsten E.   +2 more
core   +1 more source

Deep learning method for cucumber disease detection in complex environments for new agricultural productivity

BMC Plant Biology
Cucumber disease detection under complex agricultural conditions faces significant challenges due to multi-scale variation, background clutter, and hardware limitations. This study proposes YOLO-Cucumber, an improved lightweight detection algorithm based
Jun Liu, Xuewei Wang, Qian Chen, Peng Yan, Xin Liu   +4 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Lignin‐derived hard carbon anode with a robust solid electrolyte interphase for boosted sodium storage performance

Carbon Energy
Hard carbon is regarded as a promising anode candidate for sodium‐ion batteries due to its low cost, relatively low working voltage, and satisfactory specific capacity.
Jingqiang Zheng, Yulun Wu, Chaohong Guan, Danjun Wang, Yanqing Lai, Jie Li, Fuhua Yang, Simin Li, Zhian Zhang   +8 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Kansas state plan for vocational education for fiscal years 1995-1996

, 1994
"Application for Federal Funds Carl D. Perkins Vocational and Applied Technology Education Act Amendments of 1990 P.L. 100-392." "Draft." "February 8, 1994.""The Kansas State Plan/or Vocational Education for Fiscal ...
Kansas. State Board of Education.
core   +1 more source