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Design for Values in Engineering

, 2014
Values have probably always played a role in engineering design. However, in current practices and design methods, the attention for values in engineering design tends to be implicit and unsystematic. Establishing Design for Values in engineering would require overcoming this situation.
openaire   +4 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

The Effectiveness Of Using Column Formwork In A Multi-Story Building Construction Project

Rekayasa Sipil
Building the structural components is crucial for constructing a multi-story building. In the process of creating these components, which is commonly done through casting, a tool called formwork is required.
Muhammad Lawdy Dhiyaa Vansya, Eva Arifi, Ming Narto Wijaya   +2 more
doaj   +1 more source

A Value-driven Concurrent Approach for Aircraft Design-Manufacturing-Supply Chain

Production and Manufacturing Research: An Open Access Journal, 2023
The research activity proposed in this paper is framed within the context of the concurrent engineering applied to the complex aeronautical system development. The main objective is to extend the aircraft design parameters with those of manufacturing and
Giuseppa Donelli, Pier Davide Ciampa, João M.G. Mello, Felipe I.K. Odaguil, Ana P.C. Cuco, Ton van der Laan   +5 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Value Engineering of Beam, Column and Slab (Case: Library Building of Bengkalis)

Media Komunikasi Teknik Sipil, 2022
Cost construction must be planned efficiently and optimally. Value Engineering is planned approach with the aim of identifying and streamlining unnecessary costs with functional limitations and work quality (Firda, 2018).
Monika Natalia, Zulfira Mirani, Jufrinal Syahputra   +2 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Identification and Ranking of Value Engineering indicators in the projects of the worn-out urban fabric of the North East Investment Company using the Fuzzy Delphi Method [PDF]

مهندسی و مدیریت ساخت
The purpose of this research was to identify the effective indicators in conducting "value engineering" studies in the projects of the worn-out urban fabric of North East Investment Company. For this purpose, previous studies used to identify indicators.
Sayed Amir Reza Madarshahian, Ali Reza Afshari   +1 more
doaj  

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source