Results 61 to 70 of about 1,164,503 (263)

Integral approach to risk analysis and value engineering [PDF]

open access: yesTehnika, 2020
Value analysis and engineering, on one hand, and risk analysis, on the other, are two very significant approaches whose application is widely accepted in various scientific fields.
Anđelić Ognjen R.   +2 more
doaj  

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

The Value of the Classics in Engineering Education [PDF]

open access: yesTransactions of the American Institute of Electrical Engineers, 1909
Education is not the learning of a trade or profession, but is the development of the intellect and the broadening of the mind, afforded by a general knowledge of all the subjects of interest to the human race, as required to enable a man to intelligently attack and solve problems in which no previous detail experience guides, and to decide the ...
openaire   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Identifying the key Success Factors in Performing Value Engineering [PDF]

open access: yesچشم‌انداز مدیریت صنعتی, 2012
The purpose of this research is to identify the essential success factors in performing "Value Engineering" in Iran. Maurer and Posetas models were used as the basis for success factors identification.
Davood Talebi   +2 more
doaj  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

Dewatering Process for Reuse of Seabed Dredging Material and Time and Cost Optimization of the Process by Value Engineering Method

open access: yesJournal of Sustainable Construction Materials and Technologies
The decrease in resources in the world has led people to produce new solutions for the more efficient use of resources and to use various management techniques. One of the techniques used is Value Engineering.
Cansu Kayabaşı Aksu, Şenay Atabay
doaj   +1 more source

An Analysis of Expectations in Industrial Value Engineering Projects

open access: yesEuropean Journal of Business Science and Technology, 2018
This exploratory study addresses the need to identify specific and holistic upfront expectations into industrial value engineering projects for best tailored preparation of an efficient project execution.
Erhard Teschl
doaj   +1 more source

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