Results 61 to 70 of about 1,164,503 (263)
Integral approach to risk analysis and value engineering [PDF]
Value analysis and engineering, on one hand, and risk analysis, on the other, are two very significant approaches whose application is widely accepted in various scientific fields.
Anđelić Ognjen R. +2 more
doaj
Calpain small subunit homodimerization is robust and calcium‐independent
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
The Value of the Classics in Engineering Education [PDF]
Education is not the learning of a trade or profession, but is the development of the intellect and the broadening of the mind, afforded by a general knowledge of all the subjects of interest to the human race, as required to enable a man to intelligently attack and solve problems in which no previous detail experience guides, and to decide the ...
openaire +1 more source
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Identifying the key Success Factors in Performing Value Engineering [PDF]
The purpose of this research is to identify the essential success factors in performing "Value Engineering" in Iran. Maurer and Posetas models were used as the basis for success factors identification.
Davood Talebi +2 more
doaj
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
The decrease in resources in the world has led people to produce new solutions for the more efficient use of resources and to use various management techniques. One of the techniques used is Value Engineering.
Cansu Kayabaşı Aksu, Şenay Atabay
doaj +1 more source
An Analysis of Expectations in Industrial Value Engineering Projects
This exploratory study addresses the need to identify specific and holistic upfront expectations into industrial value engineering projects for best tailored preparation of an efficient project execution.
Erhard Teschl
doaj +1 more source

