Results 81 to 90 of about 11,192,129 (306)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

The Conceptual Integration of Quality Function Deployment and Value Engineering for Product Development: A Case Study of Water Dispenser

open access: yesInternational Journal of Technology
Nowadays, product development is crucial for ensuring the survival of products in the market. This article focuses on the redesign of water dispenser products based on consumer problems and desires.
Rosnani Ginting   +2 more
doaj   +1 more source

Engineering Vanderbilt; Vol. 44 No. 01, 2003

open access: yes, 2003
Engineering Vanderbilt (formerly Engineering News) is the newsletter of the Vanderbilt University School of EngineeringSchool of ...
Vanderbilt University. School of Engineering
core  

Future trends in railway engineering [PDF]

open access: yes, 2009
This article reviews the current state of railway engineering with a focus on the steady development of conventional technology that has led to the 575 km/h run of the French TGV train in 2007.
Iwnicki, Simon D., Iwnicki, S.
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Value-based software engineering [PDF]

open access: yesACM SIGSOFT Software Engineering Notes, 2003
Much of current software engineering practice and research is done in a value-neutral setting, in which every requirement, use case, object, and defect is treated as equally important; methods are presented and practiced as largely logical activities; and a "separation of concerns" is practiced, in which the responsibility of software engineers is ...
openaire   +2 more sources

Engineering Vanderbilt; Vol. 46 No. 02, 2005

open access: yes, 2005
Engineering Vanderbilt (formerly Engineering News) is the newsletter of the Vanderbilt University School of EngineeringSchool of ...
Vanderbilt University. School of Engineering
core  

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

Engineering Vanderbilt; Vol. 43 No. 01, 2002

open access: yes, 2002
Engineering Vanderbilt (formerly Engineering News) is the newsletter of the Vanderbilt University School of EngineeringSchool of ...
Vanderbilt University. School of Engineering
core  

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