Results 51 to 60 of about 1,164,503 (263)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Investigating of value engineering in reducing costs in development projects and providing a solution for cost optimization [PDF]

مهندسی و مدیریت ساخت, 2019
Value engineering is an organized effort to analyze the performance of systems, equipment, services, and institutions in order to achieve real performance with the lowest cost of project lifetime, which is consistent with the quality and safety of the ...
Ali Parvari, Majid Dalaei
doaj  

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Value Engineering in Enhancing Green Building Innovation

JGEET: Journal of Geoscience, Engineering, Environment and Technology
This research integrates the application of value engineering methods in buildings to enhance green building innovation. The use of value engineering methods, assisted by Dell'Isola Theory, functions as a structured framework to determine material ...
I Nyoman Indra Kumara, I Gede Fery Surya Tapa, Decky Cipta Indrashwara, I Wayan Dikse Pancane, Made Aryatirta Predana   +4 more
doaj   +1 more source

Application of Value Engineering in Service Project Management [PDF]

Muṭāli̒āt-i Mudīriyyat-i Ṣan̒atī, 2003
The prime objectives of Project Management are to minimize time and cost and to meet required performance. Value Engineering is an organized effort to attain optimum value in a system by providing the necessary functions to improve performance at the ...
Laya Olfat, Hassan Hashemi
doaj  

Enhancing Value and Efficiency in Egyptian Construction Projects: A Framework for Contractor Performance Assessment Using Value Engineering [PDF]

JES: Journal of Engineering Sciences
In Egypt's rapidly growing construction sector, the selection of qualified contractors remains a critical challenge for project success. While Egyptian procurement practices traditionally emphasize cost-based selection criteria, this lowest-bid approach ...
May Emam, Sherif El- Attar, Abdullah Mohammed   +2 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Cost-Saving Strategy Using Value Engineering Analysis on Basement Construction Work

International Journal of Technology
Infrastructure development in Indonesia is increasing continuously, requiring efficient project management to address cost, time, and quality challenges.
M Fanshurullah Asa, Syahreza Iskandar, Saipol Bari Bin Abd Karim, Mohammed Ali Berawi   +3 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Enhancing the Sustainability of Highway Maintenance in Egypt Through Carbon Capture and Storage: An AHP-Based Benchmarking Study

Urban Science
Investment in infrastructure is considered the foundation for economic growth. However, traditional construction and maintenance methods in Egypt are carbon-intensive, which conflicts with sustainability strategies. Therefore, there was a need to develop
Sara El-Sayed Gabr, Mamdouh Y. Saleh, Ahmed H. Ibrahim, Hossam Wefki   +3 more
doaj   +1 more source