Results 101 to 110 of about 38,520,741 (357)

Real-world ePRO use and clinical outcomes using electronic patient-reported symptom monitoring for patients with advanced non-small-cell lung cancer receiving first-line pembrolizumab

Journal of Comparative Effectiveness Research
Aim: This ambispective observational study assessed the impact of Noona, an electronic patient-reported outcomes (ePRO) platform, for patients with non-small cell lung cancer (NSCLC) treated in a community oncology setting.
L. Johnetta Blakely, Sabine Oskar, Ian Kudel, Ashley Roush, Zoya Shamsi, Toni Perry, Annette Christianson, Brittni Smith, Thomas Burke   +8 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Confiance, défiance et (abus d’) autorité dans l’éducation au Cambodge

Revue Internationale d’Éducation de Sèvres, 2016
All over the world over the last decades, complementary private education has developed considerably in parallel to regular schooling. Some forms of complementary schooling are often known as “shadow schools” because their curricula are similar to those ...
Mark Bray, Junyan Liu, Wei Zhang, Magda Nutsa Kobakhidze   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Information systems evaluation in the public sector

, 2002
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Investment appraisal techniques (TAT) range from quantitative (financially based) techniques to qualitative (non-financially based) techniques, and ...
Khalifa, Ghassan R, Khalifa, Ghassan R.
core  

Integrating PSS Design Methods with Systems for Customer Value Management and Customer Satisfaction Management

, 2011
Manufacturers today are increasingly focusing on services and concepts such as Product Service Systems (PSS) and Integrated Product Service Engineering (IPSE) have been getting more attention. On the other hand, there are various existing methods/systems
Sakao, Tomohiko,, Taabodi, Amir,
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Cognitive regulation during decision-making shifts behavioral control between ventromedial and dorsolateral prefrontal value systems

Journal of Neuroscience, 2012
Cognitive regulation is often used to influence behavioral outcomes. However, the computational and neurobiological mechanisms by which it affects behavior remain unknown.
Cendri A. C. Hutcherson, H. Plassmann, J. Gross, A. Rangel   +3 more
semanticscholar   +1 more source

Finite element solutions to boundary value problems

, 1976
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.This thesis consists of two distinct parts which deal with two-point boundary value problems and parabolic problems, respectively.
Moore, P
core  

La relation maître-élève et la question de l’autorité

Revue Internationale d’Éducation de Sèvres, 2016
From elementary school to university, the teacher – pupil relationship is characterized by a power relation that is often envisaged as a relationship of authority.
Clarisse Napporn
doaj   +1 more source