Results 141 to 150 of about 38,520,741 (357)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Decentralized Value Systems Agreements

Proceedings of the 25th International Conference on Autonomous Agents and Multiagent Systems
One of the biggest challenges of value-based decision-making is dealing with the subjective nature of values. The relative importance of a value for a particular decision varies between individuals, and people may also have different interpretations of what aligning with a value means in a given situation. While members of a society are likely to share
Arturo Hernández-Sánchez, Natalia Criado, Stella Heras, Miguel Rebollo, Jose Such   +4 more
openaire   +2 more sources

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

The role of intellectual capital in organisational value creation: An application of a theoretical model to two case studies

, 2004
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University, 17/06/2004.The research in this thesis focuses on the intangible resources of organisations.
Alwis, Dee
core  

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

A framework for evaluating the value of agricultural pest management decision support systems [PDF]

Disease management decision support systems (DSS) are typically prediction algorithms that help farmers assess the risk of an epidemic, to guide whether, and to what extent, fungicide treatment is needed.
Paveley, N., Helps, J., Jorgensen, L. N., Van den Bosch, F., Holst, N., Milne, A. E.   +5 more
core   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

How do environmental enterprise systems contribute to sustainability value? A practitioner-oriented framework

, 2016
Poon, PL ORCiD: 0000-0003-2840-2418Environmental enterprise systems (EES) are integrated software services that offer a platform to automate and manage environmental sustainability processes, data, risk and reporting. EES are widely used in organisations,
Poon, Pak-Lok, A Molla (9887465), Hoang, Giang, Pak Poon (9827297), G Hoang (9887462), Molla, Alemayehu   +5 more
core   +1 more source