Results 151 to 160 of about 38,520,741 (357)

Value co-creation in the IT service ecosystem

open access: yes, 2023
Despite the intense efforts to substantiate the value co-creation capability of IT service, current approaches only partially address the complex and dynamic nature of the IT value-creation process.
Binnewies, Sebastian   +2 more
core  

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

Understanding intraday credit in large-value payment systems [PDF]

open access: yes
This article explains how large-value payment systems work, using either gross or net settlement. The author discusses risk control in a real-time gross settlement system and analyzes the pricing of credit to provide intraday liquidity.
Ruilin Zhou
core  

Value iteration for (switched) homogeneous systems

open access: yes, 2008
In this note, we prove that dynamic programming value iteration converges uniformly for discrete-time homogeneous systems and continuous-time switched homogeneous systems.
Kolmanovsky, Ilya V.   +2 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Applying Systems Engineering to Optimise the Operation and Maintenance of Railway Vehicles throughout the Value Chain

open access: yes, 2009
A recent move by the UK government to purchase two new railway vehicle fleets from the provider offering the lowest whole-life, whole-system cost creates significant challenges to traditional manufacturers and their extended enterprises.
Clayton, Richard J.   +9 more
core  

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

A Festival at the Interstices of Value Systems [PDF]

open access: yes, 2019
AbstractThis chapter puts observations made in previous parts of this book into perspective, as it highlights the diversity of positionalities in internal relations in the context of the organization of an Iranian cultural festival. As agents that appeared in previous chapters come to interact with the young and unexperienced organizer, Behruz, during ...
openaire   +2 more sources

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