Results 161 to 170 of about 38,520,741 (357)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Engineering Systems Multiple-Domain Matrix: An organizing framework for modeling large-scale complex systems

, 2009
The scope and complexity of engineered systems are ever-increasing as burgeoning global markets, unprecedented technological capabilities, rising consumer expectations, and ever-changing social requirements present difficult design challenges that often ...
de Neufville, Richard, Rhodes, Donna H., Donna H. Rhodes, Hastings, Daniel E., Daniel E. Hastings, Jason E. Bartolomei, Richard de Neufville, Bartolomei, Jason E.   +7 more
core   +1 more source

Sistemas de valores e atitudes democráticas de estudantes universitários

Psicologia: Teoria e Pesquisa
Este artigo analisa os sistemas de valores de estudantes universitários e a relação desses sistemas com a atitude em relação à democracia. Para tanto, aplicou-se o Questionário de Valores Psicossociais e a Escala de Atitudes em Relação à Democracia a 284
Cícero Pereira, Ana Raquel Rosas Torres, Thaís S. Barros   +2 more
doaj   +1 more source

BASIC VALUE OF COMPLEX SYSTEMS

Bulletin of NTU "KhPI". Series: Strategic Management, Portfolio, Program and Project Management, 2019
The nature of the basic value is investigated in the following article. Particular attention is paid to the value’s development in the initial stages of the system’s emergence. As a result of the research it was revealed that the basic value, as an indicator, allows to inspect the state of the system at various stages of its life cycle.
openaire   +4 more sources

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Community health workers serving Veterans with chronic obstructive pulmonary disease: a pilot intervention development and feasibility study

Pilot and Feasibility Studies
Background Chronic obstructive pulmonary disease (COPD) causes significant morbidity and mortality and is a substantial burden on healthcare systems.
C. Bradley Kramer, Mayuree Rao, David B. Coultas, Jessica Young, George Sayre, Emily R. Locke, Tiffanie Fennell, Bryan J. Weiner, Karin M. Nelson, Jessica Jones-Smith, Vincent S. Fan   +10 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Information technology and business value: How complementary IT usage platform and capable resources explain IT business value variation

, 2008
Understanding information technology’s (ITs) contribution to business value is an imperative issue, and while we have attempted to untangle the relationship between IT and business value with some success, our knowledge of specific factors leading to ITs
Heales, J., Heales, Jon, Prasad, A., Prasad, Acklesh   +3 more
core   +1 more source