Results 181 to 190 of about 38,520,741 (357)
Model-Driven Process Design : Aligning Value Networks, Enterprise Goals, Services and IT Systems
, 2011 The purpose of business-IT alignment is to optimise the relation between business and IT in order to maximise the business value of IT. Successful business-IT alignment can be enabled by business processes and e-processes functioning as adaptive ...
Perjons, Erik
core
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Blockchain and value systems in the sharing economy: The illustrative case of Backfeed
, 2017 Alex Pazaitis +2 more
semanticscholar +1 more source
How to create value via object circulation in gift-systems
, 2015 Gift-systems build relationships and create various types of value for the individuals who participate in them. Organizations may also reap the benefits of gift-systems when they understand, support, and foster practices of object circulation ...
Daiane Scaraboto (10652781) +1 more
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Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Large value payment systems: principles and recent and future developments [PDF]
The present European large-value payment systems are on the verge of notable changes. Since they comprise the backbone or basic infrastructure of the whole economy, it is important that the changes are monitored and carried out in a very prudent manner ...
Iivarinen , Timo
core
Value systems of artificial intelligence and university students: theoretical dominance in large language models and religious priority in humans. [PDF]
Front PsycholSufyan NS +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source