Results 91 to 100 of about 11,480,086 (288)
Orphanet Journal of Rare Diseases, 2019 Background Barth syndrome (BTHS, OMIM 302060) is a rare, life-threatening, x-linked genetic disorder that occurs almost exclusively in males and is characterized by cardiomyopathy, neutropenia, skeletal muscle myopathy primarily affecting larger muscles,
Iyar Mazar +7 more
doaj +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Effectiveness of a Values Education Program for Preschool Students: A Teacher-Based Evaluation Study
The purpose of this study is to investigate the effectiveness of the Preschool Values Education Program, which was developed in line with the values identified through a needs analysis and prepared in accordance with the Taba Curriculum Development Model.
Kayıran, Derya, Bağçeci, Birsen
core +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Science, Technology, & Human Values
, 2021 For more than forty years Science, Technology, & Human Values has provided the forum for cutting-edge research and debate in the field of science and technology studies.
Pelizza Annalisa
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Materials Today, 2007 One of the best tips for the aspiring leader comes from that well-known business guru, William Shakespeare. I’m thinking of the much-quoted line from Hamlet: “This above all: to thine own self be true.”
openaire +3 more sources
Dermatology and TherapyIntroduction Atopic dermatitis is associated with intense itch, which has been shown to cause sleep disruption that significantly impacts the lives of patients with atopic dermatitis.
Evangeline J. Pierce +5 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Enacting Inclusive Values through Special Education Management: Integrating the Index for Inclusion within Educational Governance in Indonesia [PDF]
This study examines how inclusive values are enacted through special education management by integrating the Index for Inclusion (culture, policy, pedagogy) with a Tetra Helix governance lens.
Amka, Amka +4 more
core +1 more source