Results 61 to 70 of about 19,210,102 (353)
Ophthalmology and Therapy, 2023 Introduction Amblyopia is a neurodevelopmental vision disorder, characterized by poor vision in one or both eyes. Given the lack of existing clinical outcome assessments (COA) considered fit-for-purpose for amblyopia clinical trials, this study developed
Ann Webber +9 more
doaj +1 more source
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
, 2002 This paper studies the identification of partial differences of nonseparable structural functions. The paper considers triangular structures with no more stochastic unobservables than observable outcomes, that exhibit a degree of monotonicity with ...
Chesher, A.
core
Multiple $q$-Zeta Values [PDF]
, 2004 We introduce a $q$-analog of the multiple harmonic series commonly referred to as multiple zeta values. The multiple $q$-zeta values satisfy a $q$-stuffle multiplication rule analogous to the stuffle multiplication rule arising from the series ...
Andrews +31 more
core +4 more sources
Journal of Patient-Reported Outcomes, 2023 Background Dry eye disease (DED), Meibomian gland dysfunction (MGD), and Sjögren’s syndrome dry eye disease (SS-DED) are eye dryness conditions that show significant overlap in various symptoms of ocular discomfort.
Brigitte Sloesen +8 more
doaj +1 more source
Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms
FEBS Letters, EarlyView.Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze +3 more
wiley +1 more source
Values-Based Leadership in a Time of Values Confusion [PDF]
, 2019 Values-based leadership is slipping, perhaps morphing into an ill-defined expediency without the weight or anchor of moral principles while neglecting common decency, genuine care for others, and a vision of democracy as a moral egalitarianism.
Hester, Joseph P.
core +1 more source
Humans, robots and values [PDF]
, 2016 The issue of machines replacing humans dates back to the dawn of industrialisation. In this paper we examine what is fundamental in the distinction between human and robotic work by reflecting on the work of the classical political economists and ...
Cockshott, Paul, Renaud, Karen
core +2 more sources
A qualitative exploration of the patient experience of erosive and non-erosive hand osteoarthritis
Journal of Patient-Reported Outcomes, 2021 Background Many patients with hand osteoarthritis (HOA) experience reduced health-related quality of life. This study sought to better understand the disease and treatment experience of individuals with HOA, explore any differences in experiences between
Charlotte Panter +7 more
doaj +1 more source
FEBS Letters, EarlyView.Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma +8 more
wiley +1 more source