Results 51 to 60 of about 5,046,619 (262)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Is it Possible to Specify and Teach Acceptable and Appropriate Values for All? An Evaluation in the Context of Values Education Approaches

Sakarya University Journal of Education, 2017
Value(s), as a concept which is related with the realm of human existence, is an important theme accentuated in many fields of life from politics to business and from education to media.
Mahmut Zengin
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Aprenentatge servei: de l’Escola Nova a l’educació d’avui Service-Learning: from the Escola Nova (the New School) to education today Aprendizaje servicio: de la Escuela Nueva a la educación de hoy

Temps d'Educació, 2011
La idea d’activitat pren cos en la pràctica i la reflexió pedagògiques quan es fa evident que no és possible aprendre coneixements escoltant les explicacions dels docents i que tampoc és possible aprendre a conviure obeint les consignes dels educadors. A
Miquel Martínez Martín
doaj  

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Din Kültürü ve Ahlak Bilgisi Dersinde İşitme Engelli Öğrencilere Yönelik Değer Eğitimi Uygulamaları: Bir Eylem Araştırması

Umde Dini Tetkikler Dergisi
Engelli bireylerin eğitime erişimi, tarihsel süreçte çeşitli yaklaşımlarla ele alınmış ve bu süreç toplumun engellilik algısından etkilenmiştir. Din eğitimi ise engelli bireylerin hem bireysel gelişimlerinde hem de toplumsal uyumlarında önemli bir yere ...
Rahime Çelik
doaj   +1 more source

Is physical education relevant? Interpersonal skills, values and hybridity [PDF]

, 2005
Discussion surrounding the relevance of the document Health and Physical Education in the New Zealand Curriculum has focused on a range of areas. While some writers claim it has the potential to be emancipatory and the inclusion of interpersonal skills ...
Fitzpatrick, Katie, Pope, Clive C.
core   +1 more source