Results 21 to 30 of about 6,767,110 (315)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Cumhuriyet Döneminde Van’da Yapılan Devlet Yatırımları
Yüzüncü Yıl Üniversitesi Sosyal Bilimler Enstitüsü Dergisi, 2021 Osmanlı’dan Cumhuriyet’e geçerken, yönetim biçimi ve kurumsal açıdan dönüştürülen yapı, iktisadi, ekonomik, sosyo-kültürel açılardan da dönüşüme ihtiyaç duymaktaydı.
Rahmi Doğanay
doaj
The Current Status of Fisheries Production in Van, Türkiye
Çanakkale Onsekiz Mart University Journal of Marine Sciences and Fisheries, 2023 In recent years, the fisheries sector, which has developed rapidly in Turkey as well as all over the world, has become an important sector in the province of Van.
Muhammet DEMİR
doaj +1 more source
FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source
I. ve II. Dünya Savaşı Arası (1914-1945) Van'da Nüfus Hareketleri ve Demografik Yapı
Yüzüncü Yıl Üniversitesi Sosyal Bilimler Enstitüsü Dergisi, 2021 Bu çalışmada zaman itibariyle oldukça kozmopolit bir yapıdan homojen bir toplum yapısına geçen Van’ın yaşamış olduğu değişimin neden ve nasıl olduğunu tespit etmek amaçlandı.
Bekir Koçlar, Uğur Bozkurt
doaj
The Image of the City in Armenia: Anthropological Perspective
Urbis et Orbis: Mikroistoriâ i Semiotika Goroda, 2023 Socially significant phenomena are usually personified and embodied in the images of ancestors, ethnarchs, and heroes. The anthropomorphic symbol in the fine arts was an integral part of ancient Greek culture from the very beginning.
Viktorya Vasilyan
doaj +1 more source
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source