Results 31 to 40 of about 6,767,110 (315)

Van’da Bulunan Osmanlı Vakıfları

Yüzüncü Yıl Üniversitesi Sosyal Bilimler Enstitüsü Dergisi, 2021
Van’ı 1548 yılında tam olarak hâkimiyeti altına alan Osmanlı Devleti şehrin askerî, siyasî, iktisadî, sosyal, kültürel, dinî ve eğitim ihtiyaçlarını karşılamak için çeşitli eserler bina ettirmiştir.
Sami Ağaoğlu
doaj  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

MAIN MYTHS RELATED TO THE LAKE VAN BASIN (PRELIMINARY ATTEMPT OF CLASSIFICATION AND TYPOLOGICAL DIFFERENTIATION OF MYTHOLOGICAL NARRATIVES) [PDF]

Banber Arevelagitut'yan Instituti, 2019
As known, geographical environment, climatic conditions stipulate any region’s population’s culture and mythological imagination to a significant extent.
HASMIK HMAYAKYAN
doaj  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Physico-chemical quality of the water resources in the van region [PDF]

Eurasian Journal of Veterinary Sciences
In the present study, physico-chemical qualities of the water resources such as well, stream, fountain, tap and tank water obtained from the city of Van and its provinces (Erciş, Özalp, Saray, Muradiye, Çaldıran, Gürpınar, Gevaş and Edremit) were ...
Sema Ağaoğlu, Süleyman Alemdar, Mustafa Alişarlı, Semiha Dede   +3 more
doaj  

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Water Quality Characteristics of Some Ponds in Van (Türkiye) Province

Çanakkale Onsekiz Mart University Journal of Marine Sciences and Fisheries
This study was conducted to investigate the physical and chemical properties of the waters of Lower Tulgalı, Oymaklı, Sırımlı, Morçiçek and Sağmalı ponds in Van province during the Autumn (November 2022), Spring (May 2023) and Summer (July 2023) seasons.
Muhammet Demir
doaj   +1 more source

Hadim Devlet Anlayışı Çabasına Bir Örnek: Van ve Mülhakatındaki Hapishanelerde İyileştirme Gayretleri

Yüzüncü Yıl Üniversitesi Sosyal Bilimler Enstitüsü Dergisi, 2021
Bir arada yaşama kültürünün temelleri olan işbirliğini ve işbölümünü tehdit edenleri tenkil, te’dib ve tecrid vb. müeyyideler ile cezalandırma düşüncesi hapishane kurumlarının ihdasına sebep olmuştur.
Ercüment Topuz
doaj  

B&G rapport 925

, 2013
Becker & Van de Graaf heeft in april 2010 een Archeologisch Bureauonderzoek en een Inventariserend Veldonderzoek (IVO) verkennende fase door middel van boringen uitgevoerd in verband met de geplande (her)ontwikkeling van een plangebied aan de ...
Engel, Ba H.W.D. van den (Becker & Van de Graaf)
core   +1 more source