Results 51 to 60 of about 15,053,213 (307)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

Water Quality Characteristics of Some Ponds in Van (Türkiye) Province

open access: yesÇanakkale Onsekiz Mart University Journal of Marine Sciences and Fisheries
This study was conducted to investigate the physical and chemical properties of the waters of Lower Tulgalı, Oymaklı, Sırımlı, Morçiçek and Sağmalı ponds in Van province during the Autumn (November 2022), Spring (May 2023) and Summer (July 2023) seasons.
Muhammet Demir
doaj   +1 more source

Hadim Devlet Anlayışı Çabasına Bir Örnek: Van ve Mülhakatındaki Hapishanelerde İyileştirme Gayretleri

open access: yesYüzüncü Yıl Üniversitesi Sosyal Bilimler Enstitüsü Dergisi, 2021
Bir arada yaşama kültürünün temelleri olan işbirliğini ve işbölümünü tehdit edenleri tenkil, te’dib ve tecrid vb. müeyyideler ile cezalandırma düşüncesi hapishane kurumlarının ihdasına sebep olmuştur.
Ercüment Topuz
doaj  

Lacan’s discourse theory in the age of evidence-based practice [PDF]

open access: yes, 2006
Deze lezing vergelijkt de hedendaagse empirisch-kwantitatieve benadering omtrent effectiviteit van psychotherapieën met een bestudering van de effecten van psychotherapie aan de hand van de Lacaniaanse discourstheorie.
Desmet, Mattias
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Kıbrıs Meselesinin Yerel Basına Yansımaları (1950-1960): Vansesi Gazetesi Örneği

open access: yesYüzüncü Yıl Üniversitesi Sosyal Bilimler Enstitüsü Dergisi, 2021
Kıbrıs, tarihsel süreç içerisinde Akdeniz’de varlık gösteren bütün devletler için çok önemli olmuştur. Osmanlı Devleti, bu adanın Anadolu topraklarını savunmasındaki rolünü iyi bildiği için buradaki hâkimiyete çok önem vermiştir.
Mehmet Özalper
doaj  

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

Van’dan Hakkâri’ye İlk Telgraf Hatlarının Çekilmesi

open access: yesYüzüncü Yıl Üniversitesi Sosyal Bilimler Enstitüsü Dergisi, 2021
İlk kez Kırım Savaşı esnasında telgraf teknolojisi ile tanışan Osmanlı Devleti, zaman içerisinde bu yeni teknolojiyi ülkenin her tarafına götürmek için büyük gayret gösterdi.
Ömer Kucak
doaj  

Marine Protected Areas and commercial fisheries: the existing fishery in potential protected areas, and a modelling study of the impact of protected areas on North Sea Plaice [PDF]

open access: yes, 2009
Dit rapport presenteert resultaten van onderzoek, dat in 2005/2006 is uitgevoerd. In het kader van de Europese Vogel en Habitat Richtlijnen dienen lidstaten te beschermen gebieden op zee aan te wijzen, wat mogelijk zou leiden tot beperkingen van ...
Brinkman, A.G.   +4 more
core   +1 more source

Guibert of Gembloux’ De destructione monasterii Gemblacensis. Literary legacy and issues of authorship against the backdrop of the ‘decline’ of traditional monasticism [PDF]

open access: yes, 2016
The Benedictine Guibert of Gembloux is mostly known as the last secretary of the renowned Renish visionary Hildegard of Bingen. However, he also left behind a rich literary legacy that sheds light on the world of a traditional monk during the central ...
Moens, Sara
core   +1 more source

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