Results 41 to 50 of about 5,178,948 (316)

Van’da Bulunan Osmanlı Vakıfları

Yüzüncü Yıl Üniversitesi Sosyal Bilimler Enstitüsü Dergisi, 2021
Van’ı 1548 yılında tam olarak hâkimiyeti altına alan Osmanlı Devleti şehrin askerî, siyasî, iktisadî, sosyal, kültürel, dinî ve eğitim ihtiyaçlarını karşılamak için çeşitli eserler bina ettirmiştir.
Sami Ağaoğlu
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The Image of the City in Armenia: Anthropological Perspective

Urbis et Orbis: Mikroistoriâ i Semiotika Goroda, 2023
Socially significant phenomena are usually personified and embodied in the images of ancestors, ethnarchs, and heroes. The anthropomorphic symbol in the fine arts was an integral part of ancient Greek culture from the very beginning.
Viktorya Vasilyan
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Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

MAIN MYTHS RELATED TO THE LAKE VAN BASIN (PRELIMINARY ATTEMPT OF CLASSIFICATION AND TYPOLOGICAL DIFFERENTIATION OF MYTHOLOGICAL NARRATIVES) [PDF]

Banber Arevelagitut'yan Instituti, 2019
As known, geographical environment, climatic conditions stipulate any region’s population’s culture and mythological imagination to a significant extent.
HASMIK HMAYAKYAN
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Physico-chemical quality of the water resources in the van region [PDF]

Eurasian Journal of Veterinary Sciences
In the present study, physico-chemical qualities of the water resources such as well, stream, fountain, tap and tank water obtained from the city of Van and its provinces (Erciş, Özalp, Saray, Muradiye, Çaldıran, Gürpınar, Gevaş and Edremit) were ...
Sema Ağaoğlu, Süleyman Alemdar, Mustafa Alişarlı, Semiha Dede   +3 more
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In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Water Quality Characteristics of Some Ponds in Van (Türkiye) Province

Çanakkale Onsekiz Mart University Journal of Marine Sciences and Fisheries
This study was conducted to investigate the physical and chemical properties of the waters of Lower Tulgalı, Oymaklı, Sırımlı, Morçiçek and Sağmalı ponds in Van province during the Autumn (November 2022), Spring (May 2023) and Summer (July 2023) seasons.
Muhammet Demir
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Hadim Devlet Anlayışı Çabasına Bir Örnek: Van ve Mülhakatındaki Hapishanelerde İyileştirme Gayretleri

Yüzüncü Yıl Üniversitesi Sosyal Bilimler Enstitüsü Dergisi, 2021
Bir arada yaşama kültürünün temelleri olan işbirliğini ve işbölümünü tehdit edenleri tenkil, te’dib ve tecrid vb. müeyyideler ile cezalandırma düşüncesi hapishane kurumlarının ihdasına sebep olmuştur.
Ercüment Topuz
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