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The Nephrotoxicity of Vancomycin. [PDF]
Clinical Pharmacology & Therapeutics, 2017 Vancomycin use is often associated with nephrotoxicity. It remains uncertain, however, to what extent vancomycin is directly responsible, as numerous potential risk factors for acute kidney injury frequently coexist. Herein, we critically examine available data in adult patients pertinent to this question.
Farber, John L. +2 more
core +7 more sources
Appropriate use of vancomycin in a cardiac surgical unit [PDF]
Journal of Cardiothoracic SurgeryBackground Antibiotic resistance is a rapidly growing problem. Methicillin-resistant staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE) are major worries, particularly in developing nations where cost-effectiveness is essential.
Sanaa Mekdad +2 more
doaj +2 more sources
Palmitoleic acid sensitizes vancomycin-resistant Staphylococcus aureus to vancomycin by outpacing the expression of resistance genes [PDF]
Microbiology SpectrumThe rise in antibiotic resistance limits the availability of antibiotics to treat bacterial infections. Despite this, antibiotic development pipelines remain sparse which makes using adjuvants to reverse antibiotic resistance a promising therapeutic ...
Zajeba Tabashsum +4 more
doaj +2 more sources
3D scaffold with effective multidrug sequential release against bacteria biofilm [PDF]
Acta Biomaterialia. 49, 113-126 (2017), 2021 Bone infection is a feared complication following surgery or trauma that remains as an extremely difficult disease to deal with. So far, the outcome of therapy could be improved with the design of 3D implants, which combine the merits of osseous regeneration and local multidrug therapy so as to avoid bacterial growth, drug resistance and the feared ...
arxiv +1 more source
Pharmaceutics, 2023 Vancomycin is the front-line defense and drug of choice for the most serious and life-threatening methicillin-resistant Staphylococcus aureus (MRSA) infections.
El Tahra M. Ahmed +4 more
doaj +1 more source
Do Dose-Dependent Microbial Changes Occur during Spine Surgery as a Result of Applying Intrawound Vancomycin Powder?: A Systematic Literature Review [PDF]
Asian Spine Journal, 2018 We analyzed dose-dependent effects of vancomycin on wound infection bacteria and investigated the relationship between dose and microbial imbalances in patients treated with intrawound vancomycin powder during spine surgery.
Lunli Xie +4 more
doaj +1 more source
Multifunctional antibiotic- and zinc-containing mesoporous bioactive glass scaffolds to fight bone infection [PDF]
Acta Biomaterialia 114, 395-406 (2020), 2021 Bone regeneration is a clinical challenge that requires multiple approaches. Sometimes, it also includes the development of new osteogenic and antibacterial biomaterials to treat the occurrence of possible infection processes derived from surgery. This study evaluates the antibacterial properties of meso-macroporous scaffolds coated with gelatin and ...
arxiv +1 more source
A descriptive study of vancomycin use at Red Cross War Memorial Children’s Hospital, Cape Town
Southern African Journal of Infectious Diseases, 2023 Background: Antimicrobial stewardship principles guide the clinical use of antimicrobials, including vancomycin, but paediatric vancomycin prescribing practices have not been evaluated in South Africa.
Leonore Greybe +5 more
doaj +1 more source
Vancomycin-Associated Tubular Casts and Vancomycin Nephrotoxicity [PDF]
Kidney International Reports, 2021 Vancomycin nephrotoxicity is frequent and may be due to drug-induced acute tubular necrosis (ATN) or tubulointerstitial nephritis (TIN). Vancomycin-associated tubular cast (VTC) was recently described and may represent a novel cause of vancomycin nephrotoxicity. However, much is still unknown about VTC.Thirty-seven kidney biopsy specimens from patients
Yosu Luque +9 more
openaire +3 more sources