Results 41 to 50 of about 138,627 (294)

Crystal structure of vancomycin [PDF]

Structure, 1996
Vancomycin and other related glycopeptide antibiotics are clinically very important because they often represent the last line of defence against bacteria that have developed resistance to antibiotics. Vancomycin is believed to act by binding nascent cell wall mucopeptides terminating in the sequence D-Ala-D-Ala, weakening the resulting cell wall ...
Schäfer, Martina, Schneider, Thomas R, Sheldrick, George M   +2 more
openaire   +4 more sources

Colonic Submucosa Targeted Delivery of Probiotic and Rhein for Ulcerative Colitis Treatment

Advanced Science, EarlyView.
A novel orally drug‐probiotic co‐delivery system designated as Rh‐YBS for UC treatment, which highlights three innovations: (i) YPs involves colonic submucosa delivery via M cells; (ii) Rh (drug) promotes the colonization and growth of BS (probiotic) in the colon.
Lingqiang Li, Linxin Dai, Meisi Lin, Shuang He, Hongye Du, Dasheng Lin, Yanbin Wang, Fenglian Zhang, Sian Tao, Xiaoluo Sun, Xinggui Huang, Haihui Liu, Qian Wang, Lingling He, Kunhe Wu, Jieshu You, Minyue Zhang, Chaomei Fu, He Tu, Naijing Ye, Jibin Liu, Fei Gao   +21 more
wiley   +1 more source

Renal Protective Effect of Sulbutiamine, Thiamine, Riboflavin and their Combinations on Vancomycin-Induced Acute Renal Failure in Male Rats

Iraqi Journal of Pharmaceutical Sciences
Background: The main mechanisms thought to be involved in the pathophysiology of acute renal failure with vancomycin treatment are oxidative stress, inflammation and apoptosis.  In this study we evaluated the potential effects of sulbutiamine, thiamine,
Dayan K. Jabbar , Ghaith A. Jasim, Muthana I. Al-Ezzi   +2 more
doaj   +1 more source

Effect of an intervention targeting inappropriate continued empirical parenteral vancomycin use: a quasi-experimental study in a region of high MRSA prevalence

BMC Infectious Diseases, 2018
Background Despite vancomycin use is a major risk factor for the emergence of vancomycin resistance, it is frequently inappropriately prescribed, especially as empirical treatment.
Pyoeng Gyun Choe, Hei Lim Koo, Doran Yoon, Ji Yun Bae, Eunyoung Lee, Joo-Hee Hwang, Kyoung-Ho Song, Wan Beom Park, Ji Hwan Bang, Eu Suk Kim, Hong Bin Kim, Sang Won Park, Myoung-don Oh, Nam Joong Kim   +13 more
doaj   +1 more source

Alistipes senegalensis is Critically Involved in Gut Barrier Repair Mediated by Panax Ginseng Neutral Polysaccharides in Aged Mice

Advanced Science, EarlyView.
An integral functional axis through which GPN and functional metabolites of Alistipes senegalensis can hydrolyze tryptophan into indoles. Furthermore, the Alistipes senegalensis‐indole‐AhR pathway is found to be associated with increased expression of tight junction‐associated proteins and activation of gut stem cells.
Dandan Wang, Hui Wang, Yingna Li, Jing Lu, Xiaolei Tang, Dan Yang, Manying Wang, Daqing Zhao, Fangbing Liu, Shuai Zhang, Liwei Sun   +10 more
wiley   +1 more source

Phenotypic and molecular characterisation of Staphylococcus aureus with reduced vancomycin susceptibility derivated in vitro

Open Medicine, 2018
Vancomycin has been the primary agent used to treat serious Methicillin-resistant Staphylococcus aureus (MRSA) infection for many years. However, the rise of MRSA infection rates and the extensive use of vancomycin have led to the emergence of reduced ...
Xu Jia, Pang Long, Ma Xiao Xue, Hu Jian, Tian Yuan, Yang Ya Li, Sun Dan Dan   +6 more
doaj   +1 more source

Rash induced by enteral vancomycin therapy in an older patient in a long-term care ventilator unit: case report and review of the literature

Allergy, Asthma & Clinical Immunology, 2018
Background Oral vancomycin is a first-line treatment for severe Clostridium difficile colitis. Oral vancomycin is perceived to lack systemic absorption or systemic adverse effects; however, a few cases of hypersensitivity to oral vancomycin have been ...
Jeremy Barron, Adolfo Lattes, Esther-Lee Marcus   +2 more
doaj   +1 more source

Gut Microbiota Modulates Obesity‐Associated Skeletal Deterioration Through Macrophage Aging and Grancalcin Secretion

Advanced Science, EarlyView.
Obese gut‐microbiota derived lipopolysaccharides (LPS) induce bone marrow macrophage senescence and GCA secretion via activating TLR4/NF‐κB/MAPKs pathway. Clinically, obese patients are associated with higher serum GCA levels. Mice with depletion of GCA gene show resistance to skeletal deterioration caused by obesity and LPS‐induced chronic ...
Min Huang, Mei Huang, Ling Liu, Fang Yang, Chen He, Yu‐Chen Sun, Yu‐Rui Jiao, Xiang Tang, Jing Hou, Kai‐Xuan Chen, Wen‐Zhen He, Jie Wei, Hui‐Ling Chen, Xia Li, Chao Zeng, Guang‐Hua Lei, Chang‐Jun Li   +16 more
wiley   +1 more source

The Multitarget Compound ZLY032 Achieves Treatment of Chronic Wounds

Advanced Science, EarlyView.
ZLY032, a dual free fatty acid receptor 1/peroxisome proliferator‐activated receptor δ agonist, accelerates wound healing in normal/diabetic/methicillin‐resistant Staphylococcus aureus‐infected models by promoting angiogenesis, reducing inflammation, and exhibiting antibacterial activity via argininosuccinate lyase targeting, with demonstrated efficacy
Manyu Gong, Zhiyuan Du, Tiantian Gong, Yu Wang, Chenchen Yin, Bosi Sun, Zijia Liu, Lianru Chen, Zibin Liao, Wenxin Wang, Tianjiao Zhao, Yifei Wang, Ying Dong, Kexin Wang, Mengru Ma, Weijun Li, Jiacheng Li, Haodong Li, Congcong Lin, Ying Zhang, Yu Liu, Xin Liu, Tao Ban, Hongxia Bao, Ying Zhang, Yang Zhang, Zheng Li, Lei Jiao   +27 more
wiley   +1 more source

Vancomycin Pharmacokinetic Parameters in Patients Undergoing Hematopoietic Stem Cell Transplantation (HSCT)

International Journal of Hematology-Oncology and Stem Cell Research, 2013
Background: Vancomycin is used abundantly in patients undergoing HSCT, especially during neutropenic fever. Despite its widespread use little is known about vancomycin pharmacokinetics in HSCT patients.
Maryam Taghizadeh Ghehi, Saeed Rezaee, Alireza Hayatshahi, Molouk Hadjibabaie, Kheirollah Gholami, Mohammadreza Javadi, Seyed Hamid Khoee, Mania Radfar, Mohsen Esfandbod, Ardeshir Ghavamzadeh   +9 more
doaj