Results 61 to 70 of about 182,488 (255)

A Gut‐Brain Axis Underlying Succinate‐Associated Compulsive‐Like Behavior

Advanced Science, EarlyView.
Gut‐derived succinate is associated with an excitatory‐inhibitory imbalance in dmPFC glutamatergic neurons, involving microglial SUCNR1 activation and vagal afferent signaling via upregulated gut 5‐HT4 receptors along the DVC‐CeA‐dmPFC circuit, changes that are linked to excessive compulsive‐like behavior.
Yi Li, Ying‐Dan Zhang, Wei Wang, Xin‐Yi Wu, Di Li, Xin Gong, Fei Tian, Meng‐Yu Dai, Jian Gao, Zi‐Feng Zheng, Zi‐Yang Bi, Dong‐Dong Shi, Zhen Wang   +12 more
wiley   +1 more source

Study of antibiotic efficacy of topical vancomycin powder in treatment of infected mandibular fractures and soft tissue surgical site infections

Journal of Family Medicine and Primary Care, 2019
Aims and Objective: To study the antibiotic efficacy of topical vancomycin in infected mandibular fracture treatment and its effect in preventing surgical site infections.
Geeta Singh, Deepak Passi, Deepti Daga, Abhigyan Manas, U Vignesh, Sujay Milind Bhave   +5 more
doaj   +1 more source

Does local vancomycin powder impregnated with autogenous bone graft and bone substitute decrease the risk of deep surgical site infection in degenerative lumbar spine fusion surgery?—An ambispective study

BMC Musculoskeletal Disorders, 2022
Background Deep surgical site infection (DSSI) is one of the most challenging complications in lumbar fusion surgery. Few investigations examined the effect of vancomycin powder mixed with autogenic bone graft (ABG) and bone substitutes on preventing ...
Po-Hsin Chou, Hsi-Hsien Lin, Yu-Cheng Yao, Ming-Chau Chang, Chien-Lin Liu, Shih-Tien Wang   +5 more
doaj   +1 more source

STING/Type I Interferon Pathway Activation Confers Multimodal Therapeutic Benefits in Osteomyelitis

Advanced Science, EarlyView.
STING/type I interferon signaling counteracts osteomyelitis through coordinated control of pain, bone destruction, and abscess formation. It inhibits pathogen‐induced nociceptor activation, restrains osteoclast‐mediated bone resorption, and suppresses IL‐1β‐driven neutrophil recruitment.
Yang Chen, Jianhua Lv, Yuanqing Cai, Xuhui Yuan, Hongxin Hu, Jiayu Li, Yiming Lin, Hongyan Li, Lan Lin, Huangfeng Lin, Chaofan Zhang, Qijin Wang, Ying Huang, Zida Huang, Wenbo Li, Susheng Niu, Jianhua Lin, Bin Yang, Xinyu Fang, Wenming Zhang   +19 more
wiley   +1 more source

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

Advanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He, Yuwen Wang, Jonathan F. Gong, Yiting Lei, Fei Jin, Weihong Zhu, Rocky S. Tuan, Zhong Alan Li   +7 more
wiley   +1 more source

Comparative effectiveness of nafcillin or cefazolin versus vancomycin in methicillin-susceptible Staphylococcus aureus bacteremia

BMC Infectious Diseases, 2011
Background The high prevalence of methicillin-resistant S. aureus (MRSA) has led clinicians to select antibiotics that have coverage against MRSA, usually vancomycin, for empiric therapy for suspected staphylococcal infections.
McGregor Jessina C, Shardell Michelle D, Johnson J Kristie, Harris Anthony D, Furuno Jon P, Schweizer Marin L, Thom Kerri A, Cosgrove Sara E, Sakoulas George, Perencevich Eli N   +9 more
doaj   +1 more source

Thermal Shifts Dominate Single‐Gene Responses to Transcription‐Targeting Antibiotics

Advanced Science, EarlyView.
Thermal shifts reshape bacterial responses to transcription‐targeting antibiotics. In E. coli, temperature can dominate antibiotic‐induced genome‐wide expression, particularly outside 30°C–39°C, through changes in adenosine triphosphate (ATP), nucleoid organization, and drug‐target engagement.
Rahul Jagadeesan, Amir M. Arsh, Vatsala Chauhan, Suchintak Dash, Pooja Ravaria, Andre S. Ribeiro   +5 more
wiley   +1 more source

Vancomycin Revisited - 60 years later

Frontiers in Public Health, 2014
Vancomycin is one of the older antibiotics that has been now in clinical use close to 60 years. Earlier on, vancomycin was associated with many side effects including vestibular and renal, most likely due to impurities contained .in early vancomycin lots.
Ethan eRubinstein, Yoav eKeynan
doaj   +1 more source

Vancomycin- and Strontium-Loaded Microspheres with Multifunctional Activities against Bacteria, in Angiogenesis, and in Osteogenesis for Enhancing Infected Bone Regeneration

, 2019
Biomaterials that have capacities to simultaneously induce bone regeneration and kill bacteria are in demand because bone defects face risks of severe infection in clinical therapy.
Pengfei Wei (662637), Wei Jing (535271), Binbin Guan (3979136), Zuoying Yuan (7250933), Wenxin Zhang (112161), Jianping Mao (3408392), Yiqian Huang (7250936), Xu Zhang (49484), Xiaoping Yang (460478), Qing Cai (247954), Dafu Chen (291913)   +10 more
core   +1 more source

Oral Actinomyces Species Exposure is Associated with Anxiety‐Like Behavior, Mitochondrial Remodeling, and Altered GABAergic Pathways

Advanced Science, EarlyView.
Oral exposure to cannabis‐associated Actinomyces species, particularly A. meyeri, is associated with anxiety‐like behavior in mice in the absence of detectable bacterial translocation or overt systemic inflammation. These findings support a potential oral‐brain metabolic axis involving candidate metabolites such as arginine and argininosuccinate ...
Tabinda Salman, Zhenwu Luo, Douglas Johnson, Arshad A. Noorani, Zhuang Wan, Bogdan Bordieanu, Zhi‐wei Ye, Rachel D. Penrod, Hongxu Xian, Sylvia Fitting, Peter W. Kalivas, Wei Jiang   +11 more
wiley   +1 more source