Results 161 to 170 of about 3,124 (186)

Inversin (NPHP2) and Vangl2 are required for normal zebrafish cloaca formation

Biochemical and Biophysical Research Communications, 2023
Nephronophthisis (NPH), an autosomal recessive ciliopathy, results from mutations in more than 20 different genes (NPHPs). These gene products form protein complexes that regulate trafficking within the cilium, a microtubular structure that plays a crucial role in developmental processes.
Hui Wang, Friedemann Zaiser, Priska Eckert, Johannes Ruf, Nicolas Kayser, Anna C. Veenstra, Merle Müller, Rebecca Haas, Gerd Walz, Toma A. Yakulov   +9 more
openaire   +3 more sources

Comparative genomics on Vangl1 and Vangl2 genes

International Journal of Oncology, 2005
WNT signals are transduced to the beta-catenin pathway or the planar cell polarity (PCP) pathway. WNT - beta-catenin pathway is implicated in carcinogenesis, while WNT-PCP pathway is implicated in cell motility and metastasis. Drosophila Van Gogh (Vang), Frizzled (Fz), Starry night (Stan), Prickle (Pk) and Diego (Dgo) are PCP signaling molecules ...
Yuriko, Katoh, Masaru, Katoh
openaire   +2 more sources

Dynamics of planar cell polarity protein Vangl2 in the mouse oviduct epithelium

Mechanisms of Development, 2016
The planar cell polarity (PCP) pathway regulates morphogenesis in various organs. The polarized localization is a key feature of core PCP factors for orchestrating cell polarity in an epithelial sheet. Several studies using Drosophila melanogaster have investigated the mechanism of the polarized localization.
Toshihiko Fujimori, Takaya Abe, Tadashi Uemura   +2 more
exaly   +3 more sources

Identification of Vangl2 and Scrb1 as planar polarity genes in mammals

Nature, 2003
In mammals, an example of planar cell polarity (PCP) is the uniform orientation of the hair cell stereociliary bundles within the cochlea. The PCP pathway of Drosophila refers to a conserved signalling pathway that regulates the coordinated orientation of cells or structures within the plane of an epithelium.
Mireille, Montcouquiol, Rivka A, Rachel, Pamela J, Lanford, Neal G, Copeland, Nancy A, Jenkins, Matthew W, Kelley   +5 more
openaire   +2 more sources

The planar cell polarity Vangl2 protein: From genetics to cellular and molecular functions [PDF]

Seminars in Cell and Developmental Biology, 2018
Planar cell polarity (PCP) refers to the capacity of a tissue, typically, but not exclusively, an epithelium, to transmit directional information across the tissue plane such that its cellular constituents can differentiate, divide or move in a coordinated manner and along a common axis, generally orthogonal to the apical-basal axis.
Jean-Paul Borg
exaly   +4 more sources

VANGL2Mutations in Human Cranial Neural-Tube Defects

New England Journal of Medicine, 2010
To the Editor: Mutations in more than 200 genes are known to cause neural-tube defects in mice; less is known about the genetic cause of neural-tube defects in humans.1 Kibar and colleagues2 hypothesized that human neural-tube defects are caused by mutations in VANGL1 and VANGL2, genes that affect planar cell polarity and cause neural-tube defects in ...
Yun-Ping, Lei, Ting, Zhang, Hong, Li, Bai-Lin, Wu, Li, Jin, Hong-Yan, Wang   +5 more
openaire   +2 more sources

Vangl2 is essential for myocardial remodeling activated by Wnt/JNK signaling

Experimental Cell Research, 2018
The Wnt/JNK pathway, responsible for tissue polarity in cardiogenesis in vertebrates, has been shown to play numerous roles during differentiation and development of cardiac myocytes. Van Gogh-like-2 (Vangl2) is a core component that regulates the induction of polarized cellular and tissue morphology during animal development.
Peng, Zhang, Chunxiao, Hu, Yongyong, Li, Ying, Wang, Lei, Gao, Kai, Lu, Guanglei, Chang, Yong, Li, Shu, Qin, Dongying, Zhang   +9 more
openaire   +2 more sources

Stearoylation cycle regulates the cell surface distribution of the PCP protein Vangl2

Proceedings of the National Academy of Sciences of the United States of America
Defects in planar cell polarity (PCP) have been implicated in diverse human pathologies. Vangl2 is one of the core PCP components crucial for PCP signaling. Dysregulation of Vangl2 has been associated with severe neural tube defects and cancers.
Ying Jiafu, Baoen Chen, Ze Dong
exaly   +3 more sources

The planar cell polarity protein Vangl2 is involved in postsynaptic compartmentalization

Neuroscience Letters, 2016
The excitatory postsynaptic region of the vertebrate hippocampus is usually compartmentalized into the postsynaptic density (PSD) and N-cadherin-rich domain, which is important for synaptic adhesion. However, the molecular mechanisms underlying the compartment formation are unknown.
Tadahiro, Nagaoka, Masashi, Kishi
openaire   +2 more sources

Investigating the role of Vangl2 in the postnatal lung

2016
The non-canonical planar cell polarity (PCP) pathway is important for embryonic development of many organs including the lungs. However, comparatively little is known about the role of this pathway in adults, partly because homozygous mutations of many PCP genes result in neonatal lethality, preventing post-natal investigations. We studied Looptail (Lp)
openaire   +2 more sources