Results 51 to 60 of about 28,457 (272)

Carboranyl‐Curcuminoids for the Neutron Capture‐Based Treatment of Amyloid Aggregates in Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
The 10B‐enriched monocarbonyl analog of curcumin (BMAC) 10B‐9 enables site‐specific Boron Neutron Capture Therapy (BNCT) on amyloid‐β (Aβ) fibrils. Neutron irradiation induces histidine oxidation and fibril destabilization, as revealed by 1H‐NMR and FESEM analyses.
Sebastiano Micocci   +13 more
wiley   +1 more source

Senolytic Therapy as a Preventive Strategy for Spine Degeneration and Pain

open access: yesAdvanced Science, EarlyView.
Cellular senescence promotes inflammation, tissue degeneration, and chronic back pain. In sparc‐null mice, early oral administration of the senolytic agents o‐vanillin and RG‐7112 reduced senescent cell burden and pro‐inflammatory SASP signaling across intervertebral discs, endplates, vertebral bone, and spinal cord.
Saber Ghazizadeh   +7 more
wiley   +1 more source

Biotechnological Advances in Vanillin Production: From Natural Vanilla to Metabolic Engineering Platforms

open access: yesBioChem
Vanillin, an aromatic aldehyde, is one of the most popular flavors worldwide, extensively used in the food, cosmetics, pharmaceutical, and agrochemical industries. Despite its widespread use, less than 1% of the total vanillin production is natural, with
Arnold William Tazon   +3 more
doaj   +1 more source

A Novel CsYABBY3‐CsAS1 Feedback Loop Coordinates Trichome Differentiation and Cannabinoid Biosynthesis in Cannabis sativa L.

open access: yesAdvanced Science, EarlyView.
A novel transcriptional module involving CsYABBY3 and CsAS1 is identified to regulate cannabinoid biosynthesis and trichome development. These factors mutually activate each other and form a protein complex via a conserved residue, acting synergistically to amplify metabolic flux through a coordinate feed‐forward mechanism.
Xuewen Zhu   +18 more
wiley   +1 more source

o-Vanillin Modulates Cell Phenotype and Extracellular Vesicles of Human Mesenchymal Stem Cells and Intervertebral Disc Cells

open access: yesCells, 2022
Human mesenchymal stem cell (hMSC) and extracellular vesicle (EV) therapy is a promising treatment for discogenic low back pain (LBP). Although promising, major obstacles remain to be overcome.
Li Li   +5 more
doaj   +1 more source

Production of synthetic vanillin from coconut husk lignin via alkaline nitrobenzene oxidation [PDF]

open access: yes, 2014
Vanillin is one of the essential constituents that provide the flavor and aroma characteristics to the vanilla extract. Due to the increasing market demands, the production of synthetic vanillin has gradually developed as an alternative to the complex ...
Abdul Halim, Noor Amirah
core  

Therapeutic aspects of biologically potent vanillin derivatives: A critical review

open access: yes, 2023
4-hydroxy 3-methoxy benzaldehyde (Vanillin) is an aromatic phenolic aldehyde with unique chemical properties and pharmacological impact. Because of its potent nature, it acts as a lead for drug discovery and development techniques. Heterocyclic compounds
Yogadharshini, Nagalingam   +3 more
core   +1 more source

Controlling the Guanidinium Cation Rotation by Cation–π Interactions

open access: yesAngewandte Chemie International Edition, EarlyView.
A lanthanide π‐container has been employed to trap a guanidinium cation inside the aromatic cavity by cation–π interactions. X‐ray crystallography and solid‐state nuclear magnetic resonance (NMR) spectroscopy at fast magic‐angle spinning (MAS) frequencies have been utilized to probe the underlying host–guest interactions.
Hannah Busch   +12 more
wiley   +1 more source

Proteomic Profiling, Transcription Factor Modeling, and Genomics of Evolved Tolerant Strains Elucidate Mechanisms of Vanillin Toxicity in Escherichia coli

open access: yesmSystems, 2019
Vanillin (4-hydroxy-3-methoxybenzaldehyde) is an economically important flavor compound that can be made in bacterial cell factories, but toxicity is a major problem for cells producing this aromatic aldehyde.
Calum A. Pattrick   +5 more
doaj   +1 more source

Toward personalized healthcare: Advances in two‐dimensional nanomaterial‐based flexible electrochemical sensors for physiological monitoring

open access: yesBMEMat, EarlyView.
This review provides an overview of the properties, composites and application of two‐dimensional (2D) nanomaterials for wearable electrochemical biosensors. Also, the challenges and future prospects of utilizing 2D nanomaterials in wearable electrochemical biosensor applications are discussed.
Kou Zhang   +8 more
wiley   +1 more source

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