Results 151 to 160 of about 1,206 (173)
Long Dynamic β1-β2 Loops in M. tb MazF Toxins Affect the Interaction Modes and Strengths of the Toxin-Antitoxin Pairs. [PDF]
Int J Mol SciTang Z, Jiang P, Xie W.
europepmc +1 more source
Identification of a VapBC toxin–antitoxin system in a thermophilic bacterium Thermus thermophilus HB27openaire
The plasmid-bornehipBAoperon ofKlebsiella michiganensisencodes a potent plasmid stabilization system
Shutt-McCabe J +3 more
europepmc +1 more source
Identification of a VapBC toxin–antitoxin system in a thermophilic bacterium Thermus thermophilus HB27 [PDF]
Extremophiles, 2016 There are 12 putative toxin–antitoxin (TA) loci in the Thermus thermophilus HB27 genome, including four VapBC and three HicBA families. Expression of these seven putative toxin genes in Escherichia coli demonstrated that one putative VapC toxin TTC0125 ...
Yuqi Fan, T. Hoshino, A. Nakamura
semanticscholar +6 more sources
Higher-Order Structure in Bacterial VapBC Toxin-Antitoxin Complexes.
Sub-cellular biochemistry, 2017 Toxin-antitoxin systems are widespread in the bacterial kingdom, including in pathogenic species, where they allow rapid adaptation to changing environmental conditions through selective inhibition of key cellular processes, such as DNA replication or protein translation.
K. L. Bendtsen, D. Brodersen
semanticscholar +6 more sources
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Future Microbiology
Mycobacterium tuberculosis (Mtb) harbors a high number of Toxin-Antitoxin (TA) systems, wherein half of them belong to virulence associated proteins B and C (VapBC) family that has a characteristic PilT N-terminus domain and ribonuclease activity ...
Zoozeal Thakur +2 more
semanticscholar +3 more sources
Mycobacterium tuberculosis (Mtb) harbors a high number of Toxin-Antitoxin (TA) systems, wherein half of them belong to virulence associated proteins B and C (VapBC) family that has a characteristic PilT N-terminus domain and ribonuclease activity ...
Zoozeal Thakur +2 more
semanticscholar +3 more sources
Journal of Medicinal Chemistry, 2020
Klebsiella pneumoniae is one of the most critical opportunistic pathogens. TA systems are promising drug targets because they are related to the survival of bacterial pathogens. However, structural information on TA systems in K.
Sung-Min Kang +4 more
semanticscholar +3 more sources
Klebsiella pneumoniae is one of the most critical opportunistic pathogens. TA systems are promising drug targets because they are related to the survival of bacterial pathogens. However, structural information on TA systems in K.
Sung-Min Kang +4 more
semanticscholar +3 more sources
Featured System Toxin-antitoxin VapBC-5
Protein Structure Initiative Structural Genomics Knowledgebase, 2009 D.S. Goodsell
openalex +2 more sources
Environmental microbiology, 2014
The symbiotic nitrogen-fixing soil bacterium Sinorhizobium meliloti carries a large number of toxin-antitoxin (TA) modules both on the chromosome and megaplasmids. One of them, the vapBC-5 module that belongs to the type II systems was characterized here. It encodes an active toxin vapC-5, and was shown to be controlled negatively by the complex of its
Justine Lipuma +7 more
semanticscholar +5 more sources
The symbiotic nitrogen-fixing soil bacterium Sinorhizobium meliloti carries a large number of toxin-antitoxin (TA) modules both on the chromosome and megaplasmids. One of them, the vapBC-5 module that belongs to the type II systems was characterized here. It encodes an active toxin vapC-5, and was shown to be controlled negatively by the complex of its
Justine Lipuma +7 more
semanticscholar +5 more sources
Crystal structure of VapBC from Salmonella typhimurium
, 2020Bacterial toxin-antitoxin (TA) system has gained attention for its essential roles in cellular maintenance and survival under harsh environmental conditions such as nutrient deficiency and antibiotic treatment.
Dong-won Park +7 more
semanticscholar +1 more source