Results 131 to 140 of about 724 (156)
Novel insights into the genome organization of <i>Rhizobiaceae</i>: identification of linear plasmids. [PDF]
Microb GenomKuzmanovic N +8 more
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Identification of a VapBC toxin–antitoxin system in a thermophilic bacterium Thermus thermophilus HB27openaire
A VapBC Toxin-Antitoxin Module Is a Posttranscriptional Regulator of Metabolic Flux in Mycobacteria [PDF]
Journal of Bacteriology, 2012 ABSTRACT The largest family of toxin-antitoxin (TA) modules are encoded by the vapBC operons, but their roles in bacterial physiology remain enigmatic. Microarray analysis in Mycobacterium smegmatis overexpressing VapC/VapBC revealed a high percentage of downregulated genes with ...
Vickery Arcuș +2 more
exaly +7 more sources
Crystal structure of the VapBC-15 complex from Mycobacterium tuberculosis reveals a two-metal ion dependent PIN-domain ribonuclease and a variable mode of toxin–antitoxin assembly [PDF]
Journal of Structural Biology, 2014 Although PIN (PilT N-terminal)-domain proteins are known to have ribonuclease activity, their specific mechanism of action remains unknown. VapCs form a family of ribonucleases that possess a PIN-domain assembly and are known as toxins. The activities of VapCs are impaired by VapB antitoxins.
Uddipan Das +2 more
exaly +5 more sources
Characterization of a novel toxin-antitoxin module, VapBC, encoded by Leptospira interrogans chromosome [PDF]
Cell Research, 2004 Comparative genomic analysis of the coding sequences (CDSs) of Leptospira interrogans revealed a pair of closely linked genes homologous to the vapBC loci of many other bacteria with respect to both deduced amino acid sequences and operon organizations.
Chuan Wu, Wu Chuan, Bi Bo
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Regulation of Enteric vapBC Transcription: Induction by VapC Toxin Dimer-Breaking
Nucleic Acids Research, 2012 Toxin-antitoxin (TA) loci encode inhibitors of translation, replication or cell wall synthesis and are common elements of prokaryotic plasmids and chromosomes. Ten TA loci of Escherichia coli K-12 encode mRNases that cumulatively contribute to persistence (multidrug tolerance) of the bacterial cells. The mechanisms underlying induction and reversion of
Kristoffer Skovbo Winther +2 more
exaly +4 more sources
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Journal of Medicinal Chemistry, 2020
Klebsiella pneumoniae is one of the most critical opportunistic pathogens. TA systems are promising drug targets because they are related to the survival of bacterial pathogens. However, structural information on TA systems in K. pneumoniae remains lacking; therefore, it is necessary to explore this information for the development of antibacterial ...
Sung-Min Kang +4 more
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Klebsiella pneumoniae is one of the most critical opportunistic pathogens. TA systems are promising drug targets because they are related to the survival of bacterial pathogens. However, structural information on TA systems in K. pneumoniae remains lacking; therefore, it is necessary to explore this information for the development of antibacterial ...
Sung-Min Kang +4 more
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Future Microbiology
Mycobacterium tuberculosis (Mtb) harbors a high number of Toxin-Antitoxin (TA) systems, wherein half of them belong to virulence associated proteins B and C (VapBC) family that has a characteristic PilT N-terminus domain and ribonuclease activity. Functional insights into Mtb VapBC TA modules unraveled their role in adaptation to various host-mediated ...
Zoozeal Thakur +2 more
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Mycobacterium tuberculosis (Mtb) harbors a high number of Toxin-Antitoxin (TA) systems, wherein half of them belong to virulence associated proteins B and C (VapBC) family that has a characteristic PilT N-terminus domain and ribonuclease activity. Functional insights into Mtb VapBC TA modules unraveled their role in adaptation to various host-mediated ...
Zoozeal Thakur +2 more
openaire +2 more sources
Journal of Molecular Biology, 2009
The largest family of bacterial toxin-antitoxin (TA) modules is formed by the vapBC operons, and these are grouped together by virtue of their toxin components belonging to the PilT N-terminal domain family of proteins that are thought to function as ribonucleases.
Robson, Jennifer +4 more
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The largest family of bacterial toxin-antitoxin (TA) modules is formed by the vapBC operons, and these are grouped together by virtue of their toxin components belonging to the PilT N-terminal domain family of proteins that are thought to function as ribonucleases.
Robson, Jennifer +4 more
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Régulation transcriptionnelle et rôle fonctionnel du système toxine-antitoxine VapBC de type II dans la virulence de Shigella flexneri Shigella flexneri est un pathogène intracellulaire à Gram négatif et l'agent responsable de la dysenterie bacillaire. Sa capacité à envahir les cellules épithéliales et à se disséminer dans les tissus de
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