Results 1 to 10 of about 23,162 (212)

Toxin-Antitoxin Systems: A Key Role on Persister Formation in Salmonella enterica Serovar Typhimurium

Infection and Drug Resistance, 2022
Made Rai Dwitya Wiradiputra,1,2 Piyatip Khuntayaporn,1,3 Krit Thirapanmethee,1,3 Mullika Traidej Chomnawang1,3 1Antimicrobial Resistance Interdisciplinary Group (AmRIG), Faculty of Pharmacy, Mahidol University, Bangkok, Thailand; 2Biopharmaceutical ...
Wiradiputra MRD, Khuntayaporn P, Thirapanmethee K, Chomnawang MT   +3 more
doaj  

Redefining Therapies for Drug‐Resistant Tuberculosis: Synergistic Effects of Antimicrobial Peptides, Nanotechnology, and Computational Design

Advanced Healthcare Materials, Volume 15, Issue 14, 10 April 2026.
Antimicrobial peptide (AMP)‐loaded nanocarriers provide a multifunctional strategy to combat drug‐resistant Mycobacterium tuberculosis. By enhancing intracellular delivery, bypassing efflux pumps, and disrupting bacterial membranes, this platform restores phagolysosome fusion and macrophage function.
Christian S. Carnero Canales, Jessica Ingrid Marquez Cazorla, Renzo Marianito Marquez Cazorla, Aline Martins dos Santos, Jonatas Lobato Duarte, Letícia Oliveira Catarin Nunes, Túlio Custódio Reis, Lara Cerazi Salvador, Norival Alves Santos‐Filho, Rafael Miguel Sábio, Hélder A. Santos, Fernando Rogério Pavan   +11 more
wiley   +1 more source

A differential effect of E. coli toxin-antitoxin systems on cell death in liquid media and biofilm formation. [PDF]

PLoS ONE, 2009
Toxin-antitoxin (TA) modules are gene pairs specifying for a toxin and its antitoxin and are found on the chromosomes of many bacteria including pathogens. Here we report how each of five such TA systems in E. coli affect bacterial cell death differently
Ilana Kolodkin-Gal, Reut Verdiger, Ayalla Shlosberg-Fedida, Hanna Engelberg-Kulka   +3 more
doaj   +1 more source

Safety and Pharmacokinetics of a Four Monoclonal Antibody Combination Against Botulinum C and D Neurotoxins. [PDF]

, 2019
Botulism is caused by botulinum neurotoxin (BoNT), the most poisonous substance known. BoNTs are also classified as Tier 1 biothreat agents due to their high potency and lethality.
Cobb, Ronald R, Conrad, Fraser, Espinoza, Yero, Garcia-Rodriguez, Consuelo, Kimbler, Angie, Kraus, Carl N, Marks, James D, Martinez, Zachary, Pham, Khanh, Riling, Kathryn, Snow, Doris M, Tomic, Milan T, Wong, David   +12 more
core  

Biopharmaceuticals for Cancer Treatment: An Update

Cancer Medicine, Volume 15, Issue 4, April 2026.
ABSTRACT Cancer is one of the most debilitating diseases, causing profound physical and psychological impacts on patients. The global number of cancer patients has been steadily rising over the last few decades. The development of effective cancer therapies remains the primary focus in life science research, requiring a precise understanding of ...
Anupom Deb Nath, Yousuf Alam, Afsana Mustak Mim, Maksuda Akter, Mohammad Abbas Gani, Khondaker Muhammad Khairul Alam, Md. Nur Alam   +6 more
wiley   +1 more source

Insecticide@Silica Nanocontainers with High Cypermethrin Load and Improved Photostability

ChemNanoMat, Volume 12, Issue 4, April 2026.
Cypermethrin@Octylsilicate core@shell nanocontainers (total diameter: 34 nm, diameter of cypermethrin core: 15 nm) exhibit high colloidal stability in water and high photochemical stability of the insecticide, allowing to reduce reapplication cycles and, thus, time and costs of insecticide application.
Mark Rutschmann, Jasmin Mokinski, Claus Feldmann   +2 more
wiley   +1 more source

Keeping the wolves at bay: antitoxins of prokaryotic type II toxin-antitoxin systems

Frontiers in Molecular Biosciences, 2016
In their initial stages of discovery, prokaryotic toxin-antitoxin (TA) systems were confined to bacterial plasmids where they function to mediate the maintenance and stability of usually low- to medium-copy number plasmids through the post-segregational ...
Wai Ting eChan, Manuel eEspinosa, Chew Chieng eYeo   +2 more
doaj   +1 more source

Transcriptional cross-activation between toxin-antitoxin systems of Escherichia coli [PDF]

, 2013
BACKGROUND: Bacterial toxin-antitoxin (TA) systems are formed by potent regulatory or suicide factors (toxins) and their short-lived inhibitors (antitoxins). Antitoxins are DNA-binding proteins and auto-repress transcription of TA operons.
Niilo Kaldalu, Tanel Tenson, Toomas Mets, Villu Kasari   +3 more
core   +1 more source

Genome‐wide screen reveals a universal role of ATP in ciprofloxacin tolerance among genetically distinct Escherichia coli persisters

mLife, Volume 5, Issue 2, Page 180-198, April 2026.
Abstract Bacterial persisters show tolerance to bactericidal antibiotics and play essential roles in chronic infections; however, the general mechanisms underlying persister formation and antibiotic tolerance remain insufficiently characterized. In this study, the Escherichia coli Keio library was used to identify genes involved in ciprofloxacin ...
Zhenfang Mei, Yawen Cai, Jianfeng Huang, Kedong Zhao, Zuqin Zhang, Dandan Yu, Shiyan Lu, Zeying Lai, Thomas K. Wood, Xinmiao Fu   +9 more
wiley   +1 more source

Phylogenetic identification of bacterial MazF toxin protein motifs among probiotic strains and foodborne pathogens and potential implications of engineered probiotic intervention in food [PDF]

, 2012
BACKGROUND: Toxin-antitoxin (TA) systems are commonly found in bacteria and Archaea, and it is the most common mechanism involved in bacterial programmed cell death or apoptosis. Recently, MazF, the toxin component of the toxin-antitoxin module, has been
Jing Hu, Joshua B Gurtler, Pina M Fratamico, Vijay K Juneja, Xianghe Yan   +4 more
core   +1 more source