The Haemophilus influenzae HipBA toxin–antitoxin system adopts an unusual three-component regulatory mechanism [PDF]
IUCrJ, 2022 Type II toxin–antitoxin (TA) systems encode two proteins: a toxin that inhibits cell growth and an antitoxin that neutralizes the toxin by direct intermolecular protein–protein interactions.
Ji Sung Koo +4 more
doaj +4 more sources
Association between toxin-antitoxin system mutations and global transmission of MDR-TB [PDF]
BMC Infectious DiseasesBackground The emergence of Multidrug-Resistant Tuberculosis (MDR-TB) poses a significant threat to global tuberculosis control efforts. This study aimed to examine the influence of mutations in Toxin-Antitoxin system genes on the global transmission of ...
Yameng Li +9 more
doaj +3 more sources
Microbiology Spectrum, 2022 Toxin-antitoxin (TA) systems are genetic modules that consist of a stable protein-toxin and an unstable antitoxin that neutralizes the toxic effect. In type II TA systems, the antitoxin is a protein that inhibits the toxin by direct binding.
Esther Shmidov +7 more
doaj +3 more sources
Understanding the physiological role and cross-interaction network of VapBC35 toxin-antitoxin system from Mycobacterium tuberculosis [PDF]
Communications BiologyThe VapBC toxin-antitoxin (TA) system, composed of VapC toxin and VapB antitoxin, has gained attention due to its relative abundance in members of the M. tuberculosis complex.
Neelam Singh +4 more
doaj +2 more sources
A novel type I toxin-antitoxin system modulates persister cell formation in Staphylococcus aureus
International Journal of Medical Microbiology, 2020 A plethora of toxin-antitoxin systems exist in bacteria and has multilateral roles in bacterial pathogenesis and virulence. Toxin-antitoxin systems have been involved in persister cell formation in Escherichia coli and Mycobacterium but have not been ...
Gul Habib, Jiade Zhu, Baolin Sun
doaj +3 more sources
Microcystis aeruginosa msoT1/msoA1 Locus Displays Features of a Type I Toxin–Antitoxin System [PDF]
ToxinsType I toxin–antitoxin (TA) systems consist of a protein toxin that exerts a cytostatic or cytotoxic effect and an antisense RNA antitoxin that prevents translation of the toxin.
Matija Ruparčič, Marko Dolinar
doaj +2 more sources
Structural basis for kinase inhibition in the tripartite E. coli HipBST toxin–antitoxin system [PDF]
eLife, 2023 Many bacteria encode multiple toxin–antitoxin (TA) systems targeting separate, but closely related, cellular functions. The toxin of the Escherichia coli hipBA system, HipA, is a kinase that inhibits translation via phosphorylation of glutamyl-tRNA ...
René L Bærentsen +8 more
doaj +2 more sources
Molecular mechanism of toxin neutralization in the HipBST toxin-antitoxin system of Legionella pneumophila [PDF]
Nature Communications, 2022 Here, the authors demonstrate that the Legionella pneumophila T4SS effector protein Lpg2370 is a Ser/Thr kinase and a toxin of a tripartite HipBST toxin-antitoxin (TA) system.
Xiangkai Zhen +10 more
doaj +2 more sources
A novel double-ribonuclease toxin-antitoxin system linked to the stress response and survival of Acidovorax citrulli [PDF]
Microbiology Spectrum, 2023 Toxin-antitoxin (TA) systems are widespread among prokaryotes and can play an important role in the maintenance of genetic elements and pathogen virulence.
Xudong Wang +9 more
doaj +2 more sources
Frontiers in Genetics, 2021 Mycobacterium tuberculosis harbours nine toxin-antitoxin (TA) systems of the MazEF family. MazEF TA modules are of immense importance due to the perceived role of the MazF toxin in M. tuberculosis persistence and disease.
Soumyanetra Chandra +2 more
doaj +1 more source