Results 21 to 30 of about 28,880 (211)
Toxin-antitoxin systems in bacterial pathogenesis
Heliyon, 2023 Toxin-Antitoxin (TA) systems are abundant in prokaryotes and play an important role in various biological processes such as plasmid maintenance, phage inhibition, stress response, biofilm formation, and dormant persister cell generation. TA loci are abundant in pathogenic intracellular micro-organisms and help in their adaptation to the harsh host ...
Sonika Sonika +3 more
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The Association of the mazEF Toxin-antitoxin System and Vancomycin Resistance in Clinical Isolates of Vancomycin Resistant Enterococcus faecalis [PDF]
, 2022 Vancomycin resistant enterococci are challenging bacteria as they are difficult to be eradicated. Toxin-antitoxin (TA) systems are genetic elements located in most prokaryotic genomes.
Nawal S. Gouda, Amira M. Sultan
core +2 more sources
Structural Basis for Toxin Inhibition in the VapXD Toxin-Antitoxin System [PDF]
, 2022 Bacterial type II toxin-antitoxin (TA) modules encode a toxic protein that downregulates metabolism and a specific antitoxin that binds and inhibits the toxin during normal growth.
Daines, Dayle A. +7 more
core +1 more source
T1TAdb: the database of type I toxin–antitoxin systems [PDF]
RNA, 2021 Type I toxin–antitoxin (T1TA) systems constitute a large class of genetic modules with antisense RNA (asRNA)-mediated regulation of gene expression. They are widespread in bacteria and consist of an mRNA coding for a toxic protein and a noncoding asRNA that acts as an antitoxin preventing the synthesis of the toxin by directly base-pairing to its ...
Tourasse, Nicolas J., Darfeuille, Fabien
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Toxin-Antitoxin Systems of Staphylococcus aureus [PDF]
Toxins, 2016 Toxin-antitoxin (TA) systems are small genetic elements found in the majority of prokaryotes. They encode toxin proteins that interfere with vital cellular functions and are counteracted by antitoxins. Dependent on the chemical nature of the antitoxins (protein or RNA) and how they control the activity of the toxin, TA systems are currently divided ...
Christopher Schuster, Ralph Bertram
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Crystal Structure of the Escherichia coli Fic Toxin-Like Protein in Complex with Its Cognate Antitoxin [PDF]
, 2016 FIC domain proteins mediate post-translational modifications of target proteins, which typically results in their inactivation. Depending on the conservation of crucial active site residues, the FIC fold serves as structural scaffold for various ...
Stanger, Frédéric V. +11 more
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Toxin–Antitoxin Systems in Bacillus subtilis [PDF]
Toxins, 2019 Toxin–antitoxin (TA) systems were originally discovered as plasmid maintenance systems in a multitude of free-living bacteria, but were afterwards found to also be widespread in bacterial chromosomes. TA loci comprise two genes, one coding for a stable toxin whose overexpression kills the cell or causes growth stasis, and the other coding for an ...
Sabine Brantl, Peter Müller
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mBio, 2019 Toxin-antitoxin (TA) systems are broadly distributed modules whose biological roles remain mostly unknown. The mqsRA system is a noncanonical TA system in which the toxin and antitoxins genes are organized in operon but with the particularity that the ...
Nathan Fraikin +3 more
doaj +1 more source
Bacterial toxin-antitoxin systems [PDF]
Mobile Genetic Elements, 2011 Toxin-antitoxin (TA) systems are composed of two elements: a toxic protein and an antitoxin which is either an RNA (type I and III) or a protein (type II). Type II systems are abundant in bacterial genomes in which they move via horizontal gene transfer.
Guglielmini, Julien +1 more
openaire +4 more sources
The Bacillus cereus spoIIS programmed cell death system
Frontiers in Microbiology, 2015 Programmed cell death in bacteria is generally associated with two¬ component toxin antitoxin systems. The SpoIIS toxin-antitoxin system, consisting of a membrane bound SpoIISA toxin and a small, cytosolic antitoxin SpoIISB, was originally identified in ...
Jana eMelnicakova +3 more
doaj +1 more source