Frontiers in Microbiology, 2022 Pseudomonas aeruginosa is an important opportunistic pathogen in cystic fibrosis patients and immunocompromised individuals, and the toxin–antitoxin (TA) system is involved in bacterial virulence and phage resistance.
Mei He, Yunxue Guo
exaly +2 more sources
Sporadic phage defense in epidemic Vibrio cholerae mediated by the toxin-antitoxin system DarTG is countered by a phage-encoded antitoxin mimic [PDF]
mBioBacteria and their viral predators (phages) are constantly evolving to subvert one another. Many bacterial immune systems that inhibit phages are encoded on mobile genetic elements that can be horizontally transmitted to diverse bacteria.
Kishen M. Patel, K. Seed
semanticscholar +2 more sources
Understanding the physiological role and cross-interaction network of VapBC35 toxin-antitoxin system from Mycobacterium tuberculosis [PDF]
Communications BiologyThe VapBC toxin-antitoxin (TA) system, composed of VapC toxin and VapB antitoxin, has gained attention due to its relative abundance in members of the M. tuberculosis complex.
Neelam Singh +4 more
doaj +2 more sources
An oxygen-sensitive toxin–antitoxin system [PDF]
Nature Communications, 2016 Classical toxin–antitoxin systems in bacteria are based on silencing of a toxin by an antitoxin that, when inactivated, releases the toxin, resulting in a change in metabolism. Here, the authors characterize an oxygen-sensitive toxin–antitoxin system and
Oriol Marimon +13 more
doaj +2 more sources
Association between toxin-antitoxin system mutations and global transmission of MDR-TB [PDF]
BMC Infectious DiseasesBackground The emergence of Multidrug-Resistant Tuberculosis (MDR-TB) poses a significant threat to global tuberculosis control efforts. This study aimed to examine the influence of mutations in Toxin-Antitoxin system genes on the global transmission of ...
Yameng Li +9 more
doaj +2 more sources
Microcystis aeruginosa msoT1/msoA1 Locus Displays Features of a Type I Toxin–Antitoxin System [PDF]
ToxinsType I toxin–antitoxin (TA) systems consist of a protein toxin that exerts a cytostatic or cytotoxic effect and an antisense RNA antitoxin that prevents translation of the toxin.
Matija Ruparčič, Marko Dolinar
doaj +2 more sources
The Toxin-Antitoxin System DarTG Catalyzes Reversible ADP-Ribosylation of DNA
Molecular Cell, 2016 Summary The discovery and study of toxin-antitoxin (TA) systems helps us advance our understanding of the strategies prokaryotes employ to regulate cellular processes related to the general stress response, such as defense against phages, growth control,
Gytis Jankevicius +2 more
exaly +2 more sources
Toxin-Antitoxin Systems as Multilevel Interaction Systems
Toxins, 2014 Toxin-antitoxin (TA) systems are small genetic modules usually composed of a toxin and an antitoxin counteracting the activity of the toxic protein. These systems are widely spread in bacterial and archaeal genomes.
Nathalie Goeders, Laurence Van Melderen
doaj +2 more sources
A novel double-ribonuclease toxin-antitoxin system linked to the stress response and survival of Acidovorax citrulli [PDF]
Microbiology Spectrum, 2023 Toxin-antitoxin (TA) systems are widespread among prokaryotes and can play an important role in the maintenance of genetic elements and pathogen virulence.
Xudong Wang +9 more
doaj +2 more sources
The DarTG toxin-antitoxin system provides phage defense by ADP-ribosylating viral DNA
Nature Microbiology, 2022 Toxin-antitoxin (TA) systems are broadly distributed, yet poorly conserved, genetic elements whose biological functions are unclear and controversial.
Michele LeRoux +9 more
semanticscholar +1 more source