Results 11 to 20 of about 17,352,598 (197)

Evolution of the SpoIISABC Toxin-Antitoxin-Antitoxin System in Bacilli

Toxins, 2016
Programmed cell death in bacteria is generally associated with two-component toxin-antitoxin systems. The SpoIISABC system, originally identified in Bacillus subtilis, consists of three components: a SpoIISA toxin and the SpoIISB and SpoIISC antitoxins ...
Marek Gabriško, Imrich Barák
doaj   +4 more sources

A widespread toxin−antitoxin system exploiting growth control via alarmone signaling

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance The alarmone (p)ppGpp is a central signaling nucleotide that is synthesized by RelA-SpoT Homologue (RSH) enzymes, and rewires bacterial physiology in response to stress. It is an unanswered question why bacteria often carry multiple (p)ppGpp-
Dominik Rejman, Sofia Raquel Alves Oliveira, Tanel Tenson   +2 more
exaly   +2 more sources

Reassessing the Role of the Type II MqsRA Toxin-Antitoxin System in Stress Response and Biofilm Formation: mqsA Is Transcriptionally Uncoupled from mqsR

mBio, 2019
Toxin-antitoxin (TA) systems are broadly distributed modules whose biological roles remain mostly unknown. The mqsRA system is a noncanonical TA system in which the toxin and antitoxins genes are organized in operon but with the particularity that the ...
Nathan Fraikin, Clothilde J. Rousseau, Nathalie Goeders, Laurence Van Melderen   +3 more
doaj   +2 more sources

The endogenous Coxiella burnetii plasmid encodes a functional toxin–antitoxin system [PDF]

Mol Microbiol, 2022
Coxiella burnetii is the causative agent of Q fever. All C. burnetii isolates encode either an autonomously replicating plasmid (QpH1, QpDG, QpRS, or QpDV) or QpRS‐like chromosomally integrated plasmid sequences.
Shaun Wachter, D. Cockrell, Heather E. Miller, K. Virtaneva, Kishore Kanakabandi, Benjamin P. Darwitz, R. Heinzen, Paul A. Beare   +7 more
semanticscholar   +2 more sources

Role of VapBC4 toxin-antitoxin system of Sulfolobus acidocaldarius in heat stress adaptation [PDF]

mBio
Toxin-antitoxin (TA) systems are important for stress adaptation in prokaryotes, including persistence, antibiotic resistance, pathogenicity, and biofilm formation.
Arghya Bhowmick, Alejandra Recalde, Chandrima Bhattacharyya, Ankita Banerjee, Jagriti Das, Ulises E Rodríguez-Cruz, S. Albers, Abhrajyoti Ghosh   +7 more
semanticscholar   +2 more sources

PrrT/A, a Pseudomonas aeruginosa Bacterial Encoded Toxin-Antitoxin System Involved in Prophage Regulation and Biofilm Formation

Microbiology Spectrum, 2022
Toxin-antitoxin (TA) systems are genetic modules that consist of a stable protein-toxin and an unstable antitoxin that neutralizes the toxic effect. In type II TA systems, the antitoxin is a protein that inhibits the toxin by direct binding.
Esther Shmidov, Ilana Lebenthal-Loinger, Shira Roth, Sarit Karako-Lampert, Itzhak Zander, Sivan Shoshani, Amos Danielli, Ehud Banin   +7 more
doaj   +2 more sources

The HicAB System: Characteristics and Biological Roles of an Underappreciated Toxin-Antitoxin System [PDF]

Int J Mol Sci
Small genetic elements known as toxin-antitoxin (TA) systems are abundant in bacterial genomes and involved in stress response, phage inhibition, mobile genetic elements maintenance and biofilm formation.
Josefa Encina-Robles, Valeria Pérez-Villalobos, Paula Bustamante   +2 more
semanticscholar   +2 more sources

The Haemophilus influenzae HipBA toxin–antitoxin system adopts an unusual three-component regulatory mechanism

IUCrJ, 2022
Type II toxin–antitoxin (TA) systems encode two proteins: a toxin that inhibits cell growth and an antitoxin that neutralizes the toxin by direct intermolecular protein–protein interactions.
Ji Sung Koo, Sung-Min Kang, Won-Min Jung, Do-Hee Kim, Bong-Jin Lee   +4 more
doaj   +2 more sources

Molecular mechanism of toxin neutralization in the HipBST toxin-antitoxin system of Legionella pneumophila

Nature Communications, 2022
Here, the authors demonstrate that the Legionella pneumophila T4SS effector protein Lpg2370 is a Ser/Thr kinase and a toxin of a tripartite HipBST toxin-antitoxin (TA) system.
Xiangkai Zhen, Yongyu Wu, Jinli Ge, Jiaqi Fu, Le Ye, Niannian Lin, Zhijie Huang, Zihe Liu, Zhao-qing Luo, Jiazhang Qiu, Songying Ouyang   +10 more
doaj   +2 more sources

Identification of a Toxin–Antitoxin System That Contributes to Persister Formation by Reducing NAD in Pseudomonas aeruginosa

Microorganisms, 2021
Bacterial persisters are slow-growing or dormant cells that are highly tolerant to bactericidal antibiotics and contribute to recalcitrant and chronic infections. Toxin/antitoxin (TA) systems play important roles in controlling persister formation. Here,
Weihui Wu, Fang Bai, Yongxin Jin
exaly   +2 more sources