Results 31 to 40 of about 17,352,598 (197)
Frontiers in Genetics, 2021 Mycobacterium tuberculosis harbours nine toxin-antitoxin (TA) systems of the MazEF family. MazEF TA modules are of immense importance due to the perceived role of the MazF toxin in M. tuberculosis persistence and disease.
Soumyanetra Chandra +2 more
doaj +1 more source
Modeling sRNA-Regulated Plasmid Maintenance. [PDF]
PLoS ONE, 2017 We study a theoretical model for the toxin-antitoxin (hok/sok) mechanism for plasmid maintenance in bacteria. Toxin-antitoxin systems enforce the maintenance of a plasmid through post-segregational killing of cells that have lost the plasmid.
Chen Chris Gong, Stefan Klumpp
doaj +1 more source
Applications of toxin-antitoxin systems in synthetic biology
Engineering Microbiology, 2023 Toxin-antitoxin (TA) systems are ubiquitous in bacteria and archaea. Most are composed of two neighboring genetic elements, a stable toxin capable of inhibiting crucial cellular processes, including replication, transcription, translation, cell division ...
Jianzhong Lin +4 more
doaj +1 more source
The DarTG toxin-antitoxin system provides phage defense by ADP-ribosylating viral DNA
bioRxiv, 2021 Toxin-antitoxin (TA) systems are broadly distributed, yet poorly conserved, genetic elements whose biological functions are unclear and controversial.
Michele LeRoux +9 more
semanticscholar +1 more source
Molecular Microbiology, 2022 Toxin‐antitoxin loci regulate adaptive responses to stresses associated with the host environment and drug exposure. Phylogenomic studies have shown that Mycobacterium tuberculosis encodes a naturally expanded type II toxin‐antitoxin system, including ...
Clinton C. Dawson +3 more
semanticscholar +1 more source
Conjugative plasmid-encoded toxin–antitoxin system PrpT/PrpA directly controls plasmid copy number
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Since conjugative plasmids are usually large and may carry genes encoding functions that are detrimental to the bacterial host, minimizing plasmid copy number is critical for reducing the host burden.
S. Ni +6 more
semanticscholar +1 more source
Frontiers in Microbiology, 2021 The emergence of drug resistant bacteria is a tricky and confronted problem in modern medicine, and one of important reasons is the widespread of toxin-antitoxin (TA) systems in pathogenic bacteria. Edwardsiella piscicida (also known as E.
Dongmei Ma +5 more
semanticscholar +1 more source
Journal of Bacteriology, 2022 M. tuberculosis harbors a large number of type II toxin-antitoxin (TA) systems, the exact roles for most of which are unclear. Prior studies have reported that overexpression of several of these type II toxins inhibits bacterial growth and contributes to
Gopinath Chattopadhyay +9 more
semanticscholar +1 more source
The coevolution of toxin and antitoxin genes drives the dynamics of bacterial addiction complexes and intragenomic conflict [PDF]
, 2012 Bacterial genomes commonly contain 'addiction' gene complexes that code for both a toxin and a corresponding antitoxin. As long as both genes are expressed, cells carrying the complex can remain healthy.
Rankin, Daniel J. +7 more
core +1 more source
bioRxiv, 2022 In their natural environment, most bacteria preferentially live as complex surface-attached multicellular colonies called biofilms. Biofilms begin with a few cells adhering to a surface, where they multiply to form a mature colony.
C. Berne, S. Zappa, Y. Brun
semanticscholar +1 more source