Results 31 to 40 of about 23,162 (212)
Toxin-Antitoxin Systems in Clinical Pathogens [PDF]
Toxins, 2016 Toxin-antitoxin (TA) systems are prevalent in bacteria and archaea. Although not essential for normal cell growth, TA systems are implicated in multiple cellular functions associated with survival under stress conditions. Clinical strains of bacteria are currently causing major human health problems as a result of their multidrug resistance ...
Laura Fernández-García +6 more
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Toxin-antitoxin systems in bacterial pathogenesis
Heliyon, 2023 Toxin-Antitoxin (TA) systems are abundant in prokaryotes and play an important role in various biological processes such as plasmid maintenance, phage inhibition, stress response, biofilm formation, and dormant persister cell generation. TA loci are abundant in pathogenic intracellular micro-organisms and help in their adaptation to the harsh host ...
Sonika Sonika +3 more
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Microbiology Spectrum, 2022 Toxin-antitoxin (TA) systems are genetic modules that consist of a stable protein-toxin and an unstable antitoxin that neutralizes the toxic effect. In type II TA systems, the antitoxin is a protein that inhibits the toxin by direct binding.
Esther Shmidov +7 more
doaj +1 more source
Chaperone addiction of toxin–antitoxin systems [PDF]
Nature Communications, 2016 AbstractBacterial toxin–antitoxin (TA) systems, in which a labile antitoxin binds and inhibits the toxin, can promote adaptation and persistence by modulating bacterial growth in response to stress. Some atypical TA systems, known as tripartite toxin–antitoxin–chaperone (TAC) modules, include a molecular chaperone that facilitates folding and protects ...
Patricia Bordes +8 more
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Toxin–antitoxin systems: reversible toxicity
Current Opinion in Microbiology, 2017 Toxin-antitoxin (TA) systems encoded on the plasmids and chromosomes of bacteria are emerging as key players in stress adaptation. In particular, they have been implicated in the induction of persisters non-growing cells that can evade antibiotic exposure.
Hall, A, Gollan, B, Helaine, S
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Toxin–Antitoxin Systems in Bacillus subtilis [PDF]
Toxins, 2019 Toxin–antitoxin (TA) systems were originally discovered as plasmid maintenance systems in a multitude of free-living bacteria, but were afterwards found to also be widespread in bacterial chromosomes. TA loci comprise two genes, one coding for a stable toxin whose overexpression kills the cell or causes growth stasis, and the other coding for an ...
Sabine Brantl, Peter Müller
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mBio, 2019 Toxin-antitoxin (TA) systems are broadly distributed modules whose biological roles remain mostly unknown. The mqsRA system is a noncanonical TA system in which the toxin and antitoxins genes are organized in operon but with the particularity that the ...
Nathan Fraikin +3 more
doaj +1 more source
The coevolution of toxin and antitoxin genes drives the dynamics of bacterial addiction complexes and intragenomic conflict [PDF]
, 2012 Bacterial genomes commonly contain ‘addiction’ gene complexes that code for both a toxin and a corresponding antitoxin. As long as both genes are expressed, cells carrying the complex can remain healthy.
Brown, Sam P. +3 more
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The mazEF toxin-antitoxin system as a novel antibacterial target in Acinetobacter baumannii [PDF]
, 2014 Although analysis of toxin-antitoxin (TA) systems can be instructive, to date, there is no information on the prevalence and identity of TA systems based on a large panel of Acinetobacter baumannii clinical isolates.
Ghafourian, S +6 more
core +5 more sources
The Bacillus cereus spoIIS programmed cell death system
Frontiers in Microbiology, 2015 Programmed cell death in bacteria is generally associated with two¬ component toxin antitoxin systems. The SpoIIS toxin-antitoxin system, consisting of a membrane bound SpoIISA toxin and a small, cytosolic antitoxin SpoIISB, was originally identified in ...
Jana eMelnicakova +3 more
doaj +1 more source