Results 51 to 60 of about 17,352,598 (197)

VapBC22 toxin-antitoxin system from Mycobacterium tuberculosis is required for pathogenesis and modulation of host immune response

Science Advances, 2020
The VapBC22 toxin-antitoxin system regulates adaptation to oxidative stress and virulence in Mycobacterium tuberculosis. Virulence-associated protein B and C toxin-antitoxin (TA) systems are widespread in prokaryotes, but their precise role in physiology
Sakshi Agarwal, Arun Sharma, Rania Bouzeyen, A. Deep, Harsh Sharma, Kiran K. Mangalaparthi, K. Datta, Saqib Kidwai, H. Gowda, R. Varadarajan, R. D. Sharma, K. Thakur, Ramandeep Singh   +12 more
semanticscholar   +1 more source

Functional Characterization of the mazEF Toxin-Antitoxin System in the Pathogenic Bacterium Agrobacterium tumefaciens

Microorganisms, 2021
Agrobacterium tumefaciens is a pathogen of various plants which transfers its own DNA (T-DNA) to the host plants. It is used for producing genetically modified plants with this ability.
Wonho Choi, Yoshihiro Yamaguchi, Ji-Young Park, Sang-Hyun Park, Hyeok-Won Lee, Byung-Kwan Lim, Michael Otto, Masayori Inouye, Min-Ho Yoon, Jung-Ho Park   +9 more
doaj   +1 more source

Adenylylation of Gyrase and Topo IV by FicT Toxins Disrupts Bacterial DNA Topology [PDF]

, 2015
Toxin-antitoxin (TA) modules are ubiquitous molecular switches controlling bacterial growth via the release of toxins that inhibit cell proliferation.
Gerdes, K., Glatter, Timo, Dehio, Christoph, Alexander Harms, Goepfert, A., Scheu, P., Kenn Gerdes, Glatter, T. ; https://orcid.org/, Schirmer, T., Harms, Alexander, Christoph Dehio, Harms, A., Timo Glatter, Stanger, Frédéric Valentin, Gerdes, Kenn, Dehio, C., Schirmer, Tilman, Harms, Alexander; id_orcid, de Jong, I., de Jong, Imke Greet, Stanger, F., Tilman Schirmer, Patrick Daniel Scheu, Arnaud Goepfert, Scheu, Patrick Daniel, Frédéric Valentin Stanger, Imke Greet de Jong, Goepfert, Arnaud   +27 more
core   +1 more source

Dynamics-Based Regulatory Switches of Type II Antitoxins: Insights into New Antimicrobial Discovery

Antibiotics, 2023
Type II toxin-antitoxin (TA) modules are prevalent in prokaryotes and are involved in cell maintenance and survival under harsh environmental conditions, including nutrient deficiency, antibiotic treatment, and human immune responses. Typically, the type
Ki-Young Lee, Bong-Jin Lee
doaj   +1 more source

HigB1 Toxin in Mycobacterium tuberculosis Is Upregulated During Stress and Required to Establish Infection in Guinea Pigs

Frontiers in Microbiology, 2021
The extraordinary expansion of Toxin Antitoxin (TA) modules in the genome of Mycobacterium tuberculosis has received significant attention over the last few decades.
Arun Sharma, Kalpana Sagar, Kalpana Sagar, Neeraj Kumar Chauhan, Balaji Venkataraman, Nidhi Gupta, Tannu Priya Gosain, Nikhil Bhalla, Ramandeep Singh, Amita Gupta, Amita Gupta   +10 more
doaj   +1 more source

Expression, Purification, and Functional Analysis of Novel RelE Operon from X. nematophila

The Scientific World Journal, 2014
Bacterial toxin-antitoxin (TA) complexes induce programmed cell death and also function to relieve cell from stress by various response mechanisms. Escherichia coli RelB-RelE TA complex consists of a RelE toxin functionally counteracted by RelB antitoxin.
Jitendra Singh Rathore, Lalit Kumar Gautam   +1 more
doaj   +1 more source

Charged Amino Acids Contribute to ZorO Toxicity

Toxins, 2022
Chromosomally encoded toxin-antitoxin systems have been increasingly identified and characterized across bacterial species over the past two decades. Overproduction of the toxin gene results in cell growth stasis or death for the producing cell, but co ...
Bikash Bogati, Selene F. H. Shore, Thomas D. Nipper, Oana Stoiculescu, Elizabeth M. Fozo   +4 more
doaj   +1 more source

Structural Basis for Toxin Inhibition in the VapXD Toxin-Antitoxin System

, 2022
Bacterial type II toxin-antitoxin (TA) modules encode a toxic protein that downregulates metabolism and a specific antitoxin that binds and inhibits the toxin during normal growth.
Daines, Dayle A., Bertelsen, Marie B., Nielsen, Maja H., Bisiak, Francesco, Cunha, Marta V., Brodersen, Ditlev E., Senissar, Meriem, Molinaro, Ashley L.   +7 more
core   +1 more source

Unravelling the physiological roles of mazEF toxin–antitoxin system on clinical MRSA strain by CRISPR RNA-guided cytidine deaminase

Journal of Biomedical Sciences, 2022
Background Curiosity on toxin–antitoxin modules has increased intensely over recent years as it is ubiquitously present in many bacterial genomes, including pathogens like Methicillin-resistant Staphylococcus aureus (MRSA).
Sonia Jain, Arghya Bhowmick, B. Jeong, T. Bae, Abhrajyoti Ghosh   +4 more
semanticscholar   +1 more source

Characterization of a toxin-antitoxin system in Mycobacterium tuberculosis suggests neutralization by phosphorylation as the antitoxicity mechanism

Communications Biology, 2020
Mycobacterium tuberculosis (Mtb) encodes an exceptionally large number of toxin-antitoxin (TA) systems, supporting the hypothesis that TA systems are involved in pathogenesis.
Xia Yu, Xiaopan Gao, K. Zhu, Han Yin, Xu-Jian Mao, J. Wojdyla, B. Qin, Hairong Huang, Meitian Wang, Yi-Cheng Sun, S. Cui   +10 more
semanticscholar   +1 more source