Results 1 to 10 of about 9,494,692 (194)

Toxin–Antitoxin Systems in Pathogenic Bacteria [PDF]

Toxins, 2021
Toxin–antitoxin (TA) systems, which are ubiquitously present in plasmids, bacterial and archaeal genomes, are classified as types I to VI, according to the nature of the antitoxin and to the mode of toxin inhibition [...]
Juan C. Alonso
doaj   +11 more sources

Applications of toxin-antitoxin systems in synthetic biology [PDF]

Engineering Microbiology, 2023
Toxin-antitoxin (TA) systems are ubiquitous in bacteria and archaea. Most are composed of two neighboring genetic elements, a stable toxin capable of inhibiting crucial cellular processes, including replication, transcription, translation, cell division ...
Jianzhong Lin, Yunxue Guo, Jianyun Yao, Kaihao Tang, Xiaoxue Wang   +4 more
doaj   +6 more sources

Type II Toxin–Antitoxin Systems in Pseudomonas aeruginosa [PDF]

Toxins, 2023
Toxin–antitoxin (TA) systems are typically composed of a stable toxin and a labile antitoxin; the latter counteracts the toxicity of the former under suitable conditions.
Meng Li, Nannan Guo, Gaoyu Song, Yi Huang, Lecheng Wang, Yani Zhang, Tietao Wang   +6 more
doaj   +3 more sources

RNA Regulated Toxin-Antitoxin Systems in Pathogenic Bacteria

Frontiers in Cellular and Infection Microbiology, 2021
The dynamic host environment presents a significant hurdle that pathogenic bacteria must overcome to survive and cause diseases. Consequently, these organisms have evolved molecular mechanisms to facilitate adaptation to environmental changes within the ...
David D. Sarpong, David D. Sarpong, David D. Sarpong, Erin R. Murphy, Erin R. Murphy, Erin R. Murphy   +5 more
doaj   +2 more sources

Bioinformatic exploration reveals features of tenpIN family of type III toxin-antitoxin systems in bacteria and viruses [PDF]

Scientific Reports
Toxin-antitoxin (TA) systems in bacteria consist of two genes: one encoding a toxin that inhibits essential cellular processes and the other encoding an antitoxin that neutralizes the toxin under homeostatic conditions.
Kavyashree Nadig, Sankaran Sandhya, Mahavir Singh   +2 more
doaj   +2 more sources

Bistability in type I toxin-antitoxin systems may lead to stress-induced persister formation [PDF]

npj Systems Biology and Applications
Antibiotic persistence, characterized by a dormant subpopulation of bacterial cells that causes chronic and recurrent infections, remains poorly understood despite being recognized nearly a century ago. Toxin–antitoxin (TA) systems, which include a toxin
Sofija Markovic, Magdalena Djordjevic, Hong-Yu OU, Marko Djordjevic   +3 more
doaj   +2 more sources

Large-scale Purification of Type III Toxin-antitoxin Ribonucleoprotein Complex and its Components from Escherichia coli for Biophysical Studies

Bio-Protocol, 2023
Toxin–antitoxin (TA) systems are widespread bacterial immune systems that confer protection against various environmental stresses. TA systems have been classified into eight types (I–VIII) based on the nature and mechanism of action of the antitoxin ...
Parthasarathy Manikandan, Kavyashree Nadig, Mahavir Singh   +2 more
doaj   +1 more source

Intracellular Localization of the Proteins Encoded by Some Type II Toxin-Antitoxin Systems in Escherichia coli

mBio, 2021
Bacterial toxin-antitoxin (TA) systems encode a toxin and an antitoxin that counteracts the toxin. Such TA systems are found abundantly on bacterial chromosomes and on extrachromosomal genetic elements. The toxin is always a protein.
Alexander Mager, Tommy Safran, Hanna Engelberg-Kulka   +2 more
doaj   +1 more source

Modeling sRNA-Regulated Plasmid Maintenance. [PDF]

PLoS ONE, 2017
We study a theoretical model for the toxin-antitoxin (hok/sok) mechanism for plasmid maintenance in bacteria. Toxin-antitoxin systems enforce the maintenance of a plasmid through post-segregational killing of cells that have lost the plasmid.
Chen Chris Gong, Stefan Klumpp
doaj   +1 more source

MenT nucleotidyltransferase toxins extend tRNA acceptor stems and can be inhibited by asymmetrical antitoxin binding

Nature Communications, 2023
Mycobacterium tuberculosis, the bacterium responsible for human tuberculosis, has a genome encoding a remarkably high number of toxin-antitoxin systems of largely unknown function. We have recently shown that the M.
Xibing Xu, Ben Usher, Claude Gutierrez, Roland Barriot, Tom J. Arrowsmith, Xue Han, Peter Redder, Olivier Neyrolles, Tim R. Blower, Pierre Genevaux   +9 more
doaj   +1 more source