Results 1 to 10 of about 18,051 (202)
Structure, Evolution, and Functions of Bacterial Type III Toxin-Antitoxin Systems [PDF]
Toxins, 2016 Toxin-antitoxin (TA) systems are small genetic modules that encode a toxin (that targets an essential cellular process) and an antitoxin that neutralises or suppresses the deleterious effect of the toxin.
Nathalie Goeders +4 more
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Toxin–Antitoxin Systems in Pathogenic Bacteria [PDF]
Toxins, 2021 Toxin–antitoxin (TA) systems, which are ubiquitously present in plasmids, bacterial and archaeal genomes, are classified as types I to VI, according to the nature of the antitoxin and to the mode of toxin inhibition [...]
Juan C. Alonso
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Applications of toxin-antitoxin systems in synthetic biology [PDF]
Engineering Microbiology, 2023 Toxin-antitoxin (TA) systems are ubiquitous in bacteria and archaea. Most are composed of two neighboring genetic elements, a stable toxin capable of inhibiting crucial cellular processes, including replication, transcription, translation, cell division ...
Jianzhong Lin +4 more
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Type II Toxin–Antitoxin Systems in Pseudomonas aeruginosa [PDF]
Toxins, 2023 Toxin–antitoxin (TA) systems are typically composed of a stable toxin and a labile antitoxin; the latter counteracts the toxicity of the former under suitable conditions.
Meng Li +6 more
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Modeling sRNA-Regulated Plasmid Maintenance. [PDF]
PLoS ONE, 2017 We study a theoretical model for the toxin-antitoxin (hok/sok) mechanism for plasmid maintenance in bacteria. Toxin-antitoxin systems enforce the maintenance of a plasmid through post-segregational killing of cells that have lost the plasmid.
Chen Chris Gong, Stefan Klumpp
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Keeping the wolves at bay: antitoxins of prokaryotic type II toxin-antitoxin systems [PDF]
Frontiers in Molecular Biosciences, 2016 In their initial stages of discovery, prokaryotic toxin-antitoxin (TA) systems were confined to bacterial plasmids where they function to mediate the maintenance and stability of usually low- to medium-copy number plasmids through the post-segregational ...
Wai Ting eChan +2 more
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Bioinformatic exploration reveals features of tenpIN family of type III toxin-antitoxin systems in bacteria and viruses [PDF]
Scientific ReportsToxin-antitoxin (TA) systems in bacteria consist of two genes: one encoding a toxin that inhibits essential cellular processes and the other encoding an antitoxin that neutralizes the toxin under homeostatic conditions.
Kavyashree Nadig +2 more
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Bistability in type I toxin-antitoxin systems may lead to stress-induced persister formation [PDF]
npj Systems Biology and ApplicationsAntibiotic persistence, characterized by a dormant subpopulation of bacterial cells that causes chronic and recurrent infections, remains poorly understood despite being recognized nearly a century ago. Toxin–antitoxin (TA) systems, which include a toxin
Sofija Markovic +3 more
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Control of Toxin-Antitoxin Systems by Proteases in Mycobacterium Tuberculosis [PDF]
Frontiers in Molecular Biosciences, 2021 Toxin-antitoxin (TA) systems are small genetic elements composed of a noxious toxin and a counteracting cognate antitoxin. Although they are widespread in bacterial chromosomes and in mobile genetic elements, their cellular functions and activation ...
Patricia Bordes, Pierre Genevaux
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Bio-Protocol, 2023 Toxin–antitoxin (TA) systems are widespread bacterial immune systems that confer protection against various environmental stresses. TA systems have been classified into eight types (I–VIII) based on the nature and mechanism of action of the antitoxin ...
Parthasarathy Manikandan +2 more
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