Structural basis for kinase inhibition in the tripartite E. coli HipBST toxin–antitoxin system [PDF]
eLife, 2023 Many bacteria encode multiple toxin–antitoxin (TA) systems targeting separate, but closely related, cellular functions. The toxin of the Escherichia coli hipBA system, HipA, is a kinase that inhibits translation via phosphorylation of glutamyl-tRNA ...
René L Bærentsen +8 more
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Modeling sRNA-Regulated Plasmid Maintenance. [PDF]
PLoS ONE, 2017 We study a theoretical model for the toxin-antitoxin (hok/sok) mechanism for plasmid maintenance in bacteria. Toxin-antitoxin systems enforce the maintenance of a plasmid through post-segregational killing of cells that have lost the plasmid.
Chen Chris Gong, Stefan Klumpp
doaj +4 more sources
The Haemophilus influenzae HipBA toxin–antitoxin system adopts an unusual three-component regulatory mechanism [PDF]
IUCrJ, 2022 Type II toxin–antitoxin (TA) systems encode two proteins: a toxin that inhibits cell growth and an antitoxin that neutralizes the toxin by direct intermolecular protein–protein interactions.
Ji Sung Koo +4 more
doaj +2 more sources
Understanding the physiological role and cross-interaction network of VapBC35 toxin-antitoxin system from Mycobacterium tuberculosis [PDF]
Communications BiologyThe VapBC toxin-antitoxin (TA) system, composed of VapC toxin and VapB antitoxin, has gained attention due to its relative abundance in members of the M. tuberculosis complex.
Neelam Singh +4 more
doaj +2 more sources
Association between toxin-antitoxin system mutations and global transmission of MDR-TB [PDF]
BMC Infectious DiseasesBackground The emergence of Multidrug-Resistant Tuberculosis (MDR-TB) poses a significant threat to global tuberculosis control efforts. This study aimed to examine the influence of mutations in Toxin-Antitoxin system genes on the global transmission of ...
Yameng Li +9 more
doaj +2 more sources
Microcystis aeruginosa msoT1/msoA1 Locus Displays Features of a Type I Toxin–Antitoxin System [PDF]
ToxinsType I toxin–antitoxin (TA) systems consist of a protein toxin that exerts a cytostatic or cytotoxic effect and an antisense RNA antitoxin that prevents translation of the toxin.
Matija Ruparčič, Marko Dolinar
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Molecular mechanism of toxin neutralization in the HipBST toxin-antitoxin system of Legionella pneumophila [PDF]
Nature Communications, 2022 Here, the authors demonstrate that the Legionella pneumophila T4SS effector protein Lpg2370 is a Ser/Thr kinase and a toxin of a tripartite HipBST toxin-antitoxin (TA) system.
Xiangkai Zhen +10 more
doaj +2 more sources
A novel double-ribonuclease toxin-antitoxin system linked to the stress response and survival of Acidovorax citrulli [PDF]
Microbiology Spectrum, 2023 Toxin-antitoxin (TA) systems are widespread among prokaryotes and can play an important role in the maintenance of genetic elements and pathogen virulence.
Xudong Wang +9 more
doaj +2 more sources
A phage-encoded RNA-binding protein inhibits the antiviral activity of a toxin-antitoxin system. [PDF]
Nucleic Acids Res, 2023 Guegler CK +6 more
europepmc +3 more sources
Modulation of Hachiman defence by a type II toxin-antitoxin system via balancing trade-off between the fitness cost and antiphage activity. [PDF]
Eng MicrobiolTian X +6 more
europepmc +2 more sources