Results 21 to 30 of about 18,233,686 (171)

A novel type I toxin-antitoxin system modulates persister cell formation in Staphylococcus aureus

International Journal of Medical Microbiology, 2020
A plethora of toxin-antitoxin systems exist in bacteria and has multilateral roles in bacterial pathogenesis and virulence. Toxin-antitoxin systems have been involved in persister cell formation in Escherichia coli and Mycobacterium but have not been ...
Gul Habib, Jiade Zhu, Baolin Sun
doaj   +1 more source

Mycobacterium tuberculosis Rv0229c Shows Ribonuclease Activity and Reveals Its Corresponding Role as Toxin VapC51

Antibiotics, 2023
The VapBC system, which belongs to the type II toxin–antitoxin (TA) system, is the most abundant and widely studied system in Mycobacterium tuberculosis.
Sung-Min Kang
doaj   +1 more source

TasA-tasB, a new putative toxin-antitoxin (TA) system from Bacillus thuringiensis pGI1 plasmid is a widely distributed composite mazE-doc TA system

BMC Genomics, 2006
Background Post-segregational killing systems are present in a large variety of microorganisms. When found on plasmids, they are described as addiction systems that act to maintain the plasmid during the partitioning of the cell.
Mahillon Jacques, Fico Sarah
doaj   +1 more source

RNA Regulated Toxin-Antitoxin Systems in Pathogenic Bacteria

Frontiers in Cellular and Infection Microbiology, 2021
The dynamic host environment presents a significant hurdle that pathogenic bacteria must overcome to survive and cause diseases. Consequently, these organisms have evolved molecular mechanisms to facilitate adaptation to environmental changes within the ...
David D. Sarpong, David D. Sarpong, David D. Sarpong, Erin R. Murphy, Erin R. Murphy, Erin R. Murphy   +5 more
doaj   +1 more source

Structural Basis for Toxin Inhibition in the VapXD Toxin-Antitoxin System

, 2022
Bacterial type II toxin-antitoxin (TA) modules encode a toxic protein that downregulates metabolism and a specific antitoxin that binds and inhibits the toxin during normal growth.
Daines, Dayle A., Bertelsen, Marie B., Nielsen, Maja H., Bisiak, Francesco, Cunha, Marta V., Brodersen, Ditlev E., Senissar, Meriem, Molinaro, Ashley L.   +7 more
core   +1 more source

Functional Characterization of the mazEF Toxin-Antitoxin System in the Pathogenic Bacterium Agrobacterium tumefaciens

Microorganisms, 2021
Agrobacterium tumefaciens is a pathogen of various plants which transfers its own DNA (T-DNA) to the host plants. It is used for producing genetically modified plants with this ability.
Wonho Choi, Yoshihiro Yamaguchi, Ji-Young Park, Sang-Hyun Park, Hyeok-Won Lee, Byung-Kwan Lim, Michael Otto, Masayori Inouye, Min-Ho Yoon, Jung-Ho Park   +9 more
doaj   +1 more source

Dynamics-Based Regulatory Switches of Type II Antitoxins: Insights into New Antimicrobial Discovery

Antibiotics, 2023
Type II toxin-antitoxin (TA) modules are prevalent in prokaryotes and are involved in cell maintenance and survival under harsh environmental conditions, including nutrient deficiency, antibiotic treatment, and human immune responses. Typically, the type
Ki-Young Lee, Bong-Jin Lee
doaj   +1 more source

HigB1 Toxin in Mycobacterium tuberculosis Is Upregulated During Stress and Required to Establish Infection in Guinea Pigs

Frontiers in Microbiology, 2021
The extraordinary expansion of Toxin Antitoxin (TA) modules in the genome of Mycobacterium tuberculosis has received significant attention over the last few decades.
Arun Sharma, Kalpana Sagar, Kalpana Sagar, Neeraj Kumar Chauhan, Balaji Venkataraman, Nidhi Gupta, Tannu Priya Gosain, Nikhil Bhalla, Ramandeep Singh, Amita Gupta, Amita Gupta   +10 more
doaj   +1 more source

VapC Toxins from Mycobacterium tuberculosis are ribonucleases that differentially inhibit growth and are neutralized by cognate VapB antitoxins [PDF]

, 2011
The chromosome of Mycobacterium tuberculosis (Mtb) encodes forty seven toxin-antitoxin modules belonging to the VapBC family. The role of these modules in the physiology of Mtb and the function(s) served by their expansion are unknown.
Mizrahi, Valerie, Bhavna G Gordhan, Vickery Arcus, Diane Kuhnert, Valerie Mizrahi, Ahidjo, Bintou Ahmadou, Kuhnert, Diane, Edith E Machowski, Machowski E.E., Joanna L. Mckenzie, Garth L. Abrahams, Kuhnert D., Machowski Edith E., Abrahams, Garth L., Ahidjo B.A., Bintou Ahmadou Ahidjo, Gordhan, Bhavna G., Arcus V., Garth L Abrahams, Abrahams G.L., Machowski, Edith E., Mizrahi V., Kuhnert Diane, Ahidjo Bintou Ahmadou, McKenzie Joanna L., Arcus Vickery, Mizrahi Valerie, Edith E. Machowski, Abrahams Garth L., Gordhan B.G., McKenzie J.L., Gordhan Bhavna G., Bhavna G, Arcus, Vickery L., Bhavna G. Gordhan, McKenzie, Joanna Leigh, Joanna L McKenzie   +36 more
core   +2 more sources

The DarTG toxin-antitoxin system provides phage defense by ADP-ribosylating viral DNA

, 2023
Raw images for "The DarTG toxin-antitoxin system provides phage defense by ADP-ribosylating viral DNA"
LeRoux, M (via Mendeley Data), LeRoux, Michele   +1 more
core   +1 more source