Results 11 to 20 of about 24,122 (218)

Toxin-antitoxin system [PDF]

, 2018
Bakterije su razvile iznimnu sposobnost prilagodbe na različite životne uvjete. Uz pomoć raznih sustava i mehanizama daju brz stanični odgovor na stresore, tretman antibiotikom, stanje gladi i ostale nepovoljne uvjete. Jedan takav sustav pronađen je u
Matković, Katarina
core   +3 more sources

Structural insights into the PrpTA toxin-antitoxin system in Pseudoalteromonas rubra. [PDF]

Front Microbiol, 2022
Wang C, Niu C, Hidayatullah KM, Xue L, Zhu Z, Niu L.   +5 more
europepmc   +2 more sources

Rapid Identification of Secondary Structure and Binding Site Residues in an Intrinsically Disordered Protein Segment

Frontiers in Genetics, 2021
Mycobacterium tuberculosis harbours nine toxin-antitoxin (TA) systems of the MazEF family. MazEF TA modules are of immense importance due to the perceived role of the MazF toxin in M. tuberculosis persistence and disease.
Soumyanetra Chandra, Gopinath Chattopadhyay, Raghavan Varadarajan   +2 more
doaj   +1 more source

Applications of toxin-antitoxin systems in synthetic biology

Engineering Microbiology, 2023
Toxin-antitoxin (TA) systems are ubiquitous in bacteria and archaea. Most are composed of two neighboring genetic elements, a stable toxin capable of inhibiting crucial cellular processes, including replication, transcription, translation, cell division ...
Jianzhong Lin, Yunxue Guo, Jianyun Yao, Kaihao Tang, Xiaoxue Wang   +4 more
doaj   +1 more source

PrrT/A, a Pseudomonas aeruginosa Bacterial Encoded Toxin-Antitoxin System Involved in Prophage Regulation and Biofilm Formation

Microbiology Spectrum, 2022
Toxin-antitoxin (TA) systems are genetic modules that consist of a stable protein-toxin and an unstable antitoxin that neutralizes the toxic effect. In type II TA systems, the antitoxin is a protein that inhibits the toxin by direct binding.
Esther Shmidov, Ilana Lebenthal-Loinger, Shira Roth, Sarit Karako-Lampert, Itzhak Zander, Sivan Shoshani, Amos Danielli, Ehud Banin   +7 more
doaj   +1 more source

A plasmid-encoded inactive toxin-antitoxin system MtvT/MtvA regulates plasmid conjugative transfer and bacterial virulence in Pseudomonas aeruginosa. [PDF]

Nucleic Acids Res
Li M, Guo H, Wang L, Tao R, Song G, Cao L, Yan W, Wu Z, Liu Q, Chen Y, Gong L, Wang T, Zhang Y.   +12 more
europepmc   +2 more sources

Reassessing the Role of the Type II MqsRA Toxin-Antitoxin System in Stress Response and Biofilm Formation: mqsA Is Transcriptionally Uncoupled from mqsR

mBio, 2019
Toxin-antitoxin (TA) systems are broadly distributed modules whose biological roles remain mostly unknown. The mqsRA system is a noncanonical TA system in which the toxin and antitoxins genes are organized in operon but with the particularity that the ...
Nathan Fraikin, Clothilde J. Rousseau, Nathalie Goeders, Laurence Van Melderen   +3 more
doaj   +1 more source

The coevolution of toxin and antitoxin genes drives the dynamics of bacterial addiction complexes and intragenomic conflict [PDF]

, 2012
Bacterial genomes commonly contain ‘addiction’ gene complexes that code for both a toxin and a corresponding antitoxin. As long as both genes are expressed, cells carrying the complex can remain healthy.
Brown, Sam P., Heinemann, Jack A., Rankin, Daniel J., Turner, Leighton A.   +3 more
core   +1 more source

Unrelated toxin-antitoxin systems cooperate to induce persistence. [PDF]

, 2015
Persisters are drug-tolerant bacteria that account for the majority of bacterial infections. They are not mutants, rather, they are slow-growing cells in an otherwise normally growing population.
Fasani, Rick A, Savageau, Michael A
core   +1 more source

The Bacillus cereus spoIIS programmed cell death system

Frontiers in Microbiology, 2015
Programmed cell death in bacteria is generally associated with two¬ component toxin antitoxin systems. The SpoIIS toxin-antitoxin system, consisting of a membrane bound SpoIISA toxin and a small, cytosolic antitoxin SpoIISB, was originally identified in ...
Jana eMelnicakova, Zuzana eBecarova, Jana eMakroczyova, Imrich eBarak   +3 more
doaj   +1 more source