Results 41 to 50 of about 18,233,686 (171)

Orphan Toxin OrtT (YdcX) of Escherichia coli Reduces Growth during the Stringent Response

Toxins, 2015
Toxin/antitoxin (TA) systems are nearly universal in prokaryotes; toxins are paired with antitoxins which inactivate them until the toxins are utilized. Here we explore whether toxins may function alone; i.e., whether a toxin which lacks a corresponding ...
Sabina Islam, Michael J. Benedik, Thomas K. Wood   +2 more
doaj   +1 more source

Characterization of a Streptococcus mutans intergenic region containing a small toxic peptide and its cis-encoded antisense small RNA antitoxin. [PDF]

PLoS ONE, 2013
Toxin-antitoxin (TA) modules consist of a pair of genes that encode two components: a protein toxin and an antitoxin, which may be in the form of either a labile protein or an antisense small RNA. Here we describe, to the best of our knowledge, the first
Stephanie Koyanagi, Céline M Lévesque
doaj   +1 more source

Structural Basis of Shiga Toxin Neutralization by Human Antibodies Targeting Canonical Receptor‐Binding and Non‐Canonical Assembly Sites

Advanced Science, EarlyView.
Cryo‐electron microscopy structures reveal two distinct neutralization mechanisms of fully human monoclonal antibodies targeting the Shiga toxin 1a B subunit. RDS059 occludes the Gb3 receptor‐binding site, whereas RDS045 engages a lateral quaternary epitope to disrupt holotoxin assembly.
Jianting Ke, Xin Li, Xiaoli Wang, Zhaoxia Huang, Shaojie Xue, Yuyang Liu, Jing Pan, Guowei Hu, Yayu Wang, Cheng Wang, Shoudeng Chen   +10 more
wiley   +1 more source

The Collective Power of Bacteria as a Blueprint for Emergent Intelligence

Advanced Intelligent Systems, EarlyView.
Small cells, powerful collectives. Bacteria demonstrate how sophisticated behaviors can emerge from many simple individuals working together. We explore the remarkable world of bacterial communities and the mechanisms that underpin their complex emergent behaviors, enabling impressive adaptability, robustness, and responsiveness to changing ...
Johanna A. Blee, Thomas E. Gorochowski, Sabine Hauert   +2 more
wiley   +1 more source

Vaginal host–microbe signatures linked to placental outcomes in mares

Equine Veterinary Journal, EarlyView.
Abstract Background Ascending placentitis is a leading cause of late‐term pregnancy loss in mares. Although pathogens are presumed to ascend from the caudal reproductive tract, the association between the vaginal microbiome and placentitis has not been systematically examined.
Machteld van Heule, Babiche Heil, Jamie K. Norris, Kristene Gedye, Xiaoxiao Lin, Ward De Spiegelaere, Peter Daels, Pouya Dini   +7 more
wiley   +1 more source

A new type V toxin-antitoxin system where mRNA for toxin GhoT is cleaved by antitoxin GhoS

, 2012
International audienceAmong bacterial toxin-antitoxin systems, to date no antitoxin has been identified that functions by cleaving toxin mRNA. Here we show that YjdO (renamed GhoT) is a membrane lytic peptide that causes ghost cell formation (lysed cells
Wolfgang Peti, Zheng, Kevin, Rebecca Page, Hsin-Yao Cheng, Torsten Herrmann, Xiaoxue Wang, Devon O Osbourne, Michael J Benedik, Cecilia Quiroga, Viviana Sanchez-Torres, Seok Hoon Hong, Kevin Zheng, Wang, Xiaoxue, Sanchez-Torres, Viviana, Thomas K Wood, Lord, Dana M, Benedik, Michael J, Cheng, Hsin-Yao, Quiroga, Cecilia, Wood, Thomas K, Peti, Wolfgang, Herrmann, Torsten, Dana M Lord, Page, Rebecca, Hong, Seok Hoon, Osbourne, Devon O   +25 more
core   +1 more source

Automated discovery and phylogenetic analysis of new toxin-antitoxin systems. [PDF]

, 2008
Although often viewed as elements "at the service of" bacteria, plasmids exhibit replication and maintenance mechanisms that make them purely "selfish DNA" candidates.
Michel C Milinkovitch, Guglielmini, Julien, Szpirer, Cédric, Cedric Y Szpirer, Guglielmini Julien, Milinkovitch, Michel, Szpirer Cédric, Milinkovitch Michel C, Julien Guglielmini   +8 more
core   +1 more source

Architecture and Evolution of Prokaryotic Multicellularity: Common Patterns and Diversity

Molecular Microbiology, EarlyView.
Prokaryotes form diverse multicellular structures, like biofilms, filaments, and aggregates, comprising hallmark traits such as adhesion, communication, differentiation, and programmed cell death. This review explores how these forms develop, function, and evolve in response to environmental cues.
Genevieve Sohl, Arthur Schubert, Thorsten Mascher, Enrico Sandro Colizzi   +3 more
wiley   +1 more source

Molecular mechanism of toxin neutralization in the HipBST toxin-antitoxin system of Legionella pneumophila

Nature Communications, 2022
Here, the authors demonstrate that the Legionella pneumophila T4SS effector protein Lpg2370 is a Ser/Thr kinase and a toxin of a tripartite HipBST toxin-antitoxin (TA) system.
Xiangkai Zhen, Yongyu Wu, Jinli Ge, Jiaqi Fu, Le Ye, Niannian Lin, Zhijie Huang, Zihe Liu, Zhao-qing Luo, Jiazhang Qiu, Songying Ouyang   +10 more
doaj   +1 more source

The Biochemistry of VapBC Toxin-Antitoxins [PDF]

, 2011
The VapBC toxin-antitoxin (TA) systems were first identified in 2005 and little is known about their contemporary biological function, despite the fact that VapBC TAs are the largest TA family and are widespread in bacteria and archaea (Arcus, Rainey ...
McKenzie, Joanna Leigh
core