Results 61 to 70 of about 24,122 (218)

Control of Toxin-Antitoxin Systems by Proteases in Mycobacterium Tuberculosis

Frontiers in Molecular Biosciences, 2021
Toxin-antitoxin (TA) systems are small genetic elements composed of a noxious toxin and a counteracting cognate antitoxin. Although they are widespread in bacterial chromosomes and in mobile genetic elements, their cellular functions and activation ...
Patricia Bordes, Pierre Genevaux
doaj   +1 more source

Molecular processes underlying synergistic linuron mineralization in a triple-species bacterial consortium biofilm revealed by differential transcriptomics [PDF]

, 2018
The proteobacteria Variovorax sp. WDL1, Comamonas testosteroni WDL7, and Hyphomicrobium sulfonivorans WDL6 compose a triple-species consortium that synergistically degrades and grows on the phenylurea herbicide linuron.
Anders, Aziz, Beliaev, Bers, Bleichrodt, Boon, Breugelmans, Breugelmans, Cerqueda-Garcia, Colwell, Dealtry, Dejonghe, Dwyer, Foster, Frias-Lopez, Garbeva, Garcia, Gonzalez-Torres, Hansen, Horemans, Horemans, Horemans, Horemans, Horinouchi, Ilut, Kanehisa, Kell, Kimes, Krol, Love, MacLean, Maeyer, Nadell, Palama, Perez, Reasoner, Rickard, Rosenthal, Russell, Sabag-Daigle, Sambrook, Shimoyama, Subramoni, Suzuki, Tai, Teramoto, Ward, Wenter, West, Wu, Zerbino, Zgur-Bertok, Zhou   +52 more
core   +2 more sources

Bioinformatics‐Driven Design and Evaluation of Recombinant Multi‐Epitope Immunogens Derived From Snake Venom Toxins as Potential Antivenom Candidates

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Snakebite envenomation is a major public health concern, particularly in low‐ and middle‐income regions where access to safe and effective antivenoms is limited. Traditional antivenoms, derived from immunization with crude venom, often trigger adverse reactions and lack specificity against key venom components.
Hanan Maoz, Amir Elalouf
wiley   +1 more source

Genome-wide transcription start site profiling in biofilm-grown Burkholderia cenocepacia J2315 [PDF]

, 2015
Background: Burkholderia cenocepacia is a soil-dwelling Gram-negative Betaproteobacterium with an important role as opportunistic pathogen in humans. Infections with B.
Coenye, Tom, Deforce, Dieter, Förstner, Konrad, Sass, Andrea, Van Acker, Heleen, Van Nieuwerburgh, Filip, Vogel, Jörg   +6 more
core   +2 more sources

CLINICO–Demographic Profile and Outcomes of Hospitalised Children With Diphtheria in A Tertiary Care Hospital of Peshawar

Acta Paediatrica, EarlyView.
ABSTRACT Aim To determine the clinico‐demographic profile and predictors of mortality in hospitalised children with diphtheria. Methods This retrospective cohort study included 202 children aged 5–16 years diagnosed with diphtheria per WHO criteria at Lady Reading Hospital, Peshawar, from January 2023 to December 2024. Data on demographics, vaccination
Amir Muhammad, Ashfaq Ahmed, Waqas Naseem, Ale Azad Othman, Mohsin Hassan, Lyaba Atta, Muhammad Tahir   +6 more
wiley   +1 more source

Characterization of the interaction and cross-regulation of three Mycobacterium tuberculosis RelBE modules. [PDF]

PLoS ONE, 2010
RelBE represents a typical bacterial toxin-antitoxin (TA) system. Mycobacterium tuberculosis H37Rv, the pathogen responsible for human tuberculosis, contains three RelBE-like modules, RelBE, RelFG, and RelJK, which are at least partly expressed in human ...
Min Yang, Chunhui Gao, Yi Wang, Hua Zhang, Zheng-Guo He   +4 more
doaj   +1 more source

The bacterial Type III toxin-antitoxin system, ToxIN, is a dynamic protein-RNA complex with stability-dependent antiviral abortive infection activity. [PDF]

, 2018
Bacteria have evolved numerous defense systems to protect themselves from viral (bacteriophage) infection. The ToxIN system of Pectobacterium atrosepticum is a Type III toxin-antitoxin complex and "altruistic suicide" anti-phage system, which kills phage-
Akusobi, Chidiebere, Broadhurst, William R, Salmond, George PC, Short, Francesca L   +3 more
core   +2 more sources

The 3D genome of Gigaspora margarita unveils stable chromatin and nucleolar organization and symbiont‐dependent genome dynamics

New Phytologist, EarlyView.
Summary Arbuscular mycorrhizal fungi (AMF) are widespread plant symbionts that enhance nutrient acquisition and influence ecosystem productivity. Previous chromosome‐level assemblies of the model species Rhizophagus irregularis revealed a two‐compartment genome architecture (active A and repressed B chromatin compartments), yet its conservation across ...
Ken Mugambi, Jordana Oliveira, Franco Magurno, Alessandra Salvioli di Fossalunga, Mara Novero, Luisa Lanfranco, Stefano Ghignone, Gökalp Yildirir, Yan Wang, Paola Bonfante, Nicolas Corradi   +10 more
wiley   +1 more source

The VapBC-4 Characterization Indicates It Is a Bona Fide Toxin-Antitoxin Module of Leptospira interrogans: Initial Evidence for a Role in Bacterial Adaptation

Microorganisms
Toxin-antitoxin (TA) systems are one of the bacterial adaptation mechanisms to adverse conditions. Leptospira interrogans serovar Copenhageni contains nine putative TA systems.
Bruna Oliveira Pigatto Azevedo, Deborah Kohn Damiano, Aline Florencio Teixeira, Ana Lucia Tabet Oller Nascimento, Luis Guilherme Virgilio Fernandes, Alexandre Paulo Yague Lopes   +5 more
doaj   +1 more source

Molecular Characterization of Protease Activity in Serratia sp. Strain SCBI and Its Importance in Cytotoxicity and Virulence [PDF]

, 2014
A newly recognized Serratia species, termed South African Caenorhabditis briggsae isolate (SCBI), is both a mutualist of the nematode Caenorhabditis briggsae KT0001 and a pathogen of lepidopteran insects. Serratia sp.
Petersen, Lauren M., Tisa, Louis S.
core   +2 more sources