Results 61 to 70 of about 13,707 (133)

Genomic epidemiology and lineage‐specific risk stratification of tet(X4)‐mediated tigecycline resistance along the pork production chain: A One Health perspective

iMetaOmics, Volume 3, Issue 2, June 2026.
Genome surveillance across a swine‐associated One Health continuum in China shows that slaughterhouses act as major enrichment nodes for tet(X4)‐mediated tigecycline resistance, driven by putative clonal transmission and stable plasmid backbones. Integrating global datasets enables lineage‐specific risk stratification, highlighting key control points ...
Qin Wang, Qiwu Yuan, Xuan Chen, Yujing Zhong, Ke Wu, Renqiao Wen, Luya Liu, Xiaoqin Wang, Cui Li, Hongning Wang, Changwei Lei   +10 more
wiley   +1 more source

Solar–Chemical Hybrid‐Driven Phototroph for Biosynthesis

Rare Metals, Volume 45, Issue 8, August 2026.
Shuo Liu, Shilong Chen, Xijun Liu
wiley   +1 more source

Evolution of the SpoIISABC Toxin-Antitoxin-Antitoxin System in Bacilli

Toxins, 2016
Programmed cell death in bacteria is generally associated with two-component toxin-antitoxin systems. The SpoIISABC system, originally identified in Bacillus subtilis, consists of three components: a SpoIISA toxin and the SpoIISB and SpoIISC antitoxins ...
Marek Gabriško, Imrich Barák
doaj   +1 more source

Bistability in type I toxin-antitoxin systems may lead to stress-induced persister formation

npj Systems Biology and Applications
Antibiotic persistence, characterized by a dormant subpopulation of bacterial cells that causes chronic and recurrent infections, remains poorly understood despite being recognized nearly a century ago. Toxin–antitoxin (TA) systems, which include a toxin
Sofija Markovic, Magdalena Djordjevic, Hong-Yu OU, Marko Djordjevic   +3 more
doaj   +1 more source

A common origin for the bacterial toxin-antitoxin systems parD and ccd, suggested by analyses of toxin/target and toxin/antitoxin interactions.

PLoS ONE, 2012
Bacterial toxin-antitoxin (TA) systems encode two proteins, a potent inhibitor of cell proliferation (toxin) and its specific antidote (antitoxin). Structural data has revealed striking similarities between the two model TA toxins CcdB, a DNA gyrase ...
Andrew B Smith, Juan López-Villarejo, Elizabeth Diago-Navarro, Lesley A Mitchenall, Arjan Barendregt, Albert J Heck, Marc Lemonnier, Anthony Maxwell, Ramón Díaz-Orejas   +8 more
doaj   +1 more source

Development of an antibiotic marker-free platform for heterologous protein production in Streptomyces

Microbial Cell Factories, 2017
Background The industrial use of enzymes produced by microorganisms is continuously growing due to the need for sustainable solutions. Nevertheless, many of the plasmids used for recombinant production of proteins in bacteria are based on the use of ...
Laura Sevillano, Margarita Díaz, Ramón I. Santamaría   +2 more
doaj   +1 more source

The Toxin of VapBC-1 Toxin-Antitoxin Module from Leptospira interrogans Is a Ribonuclease That Does Not Arrest Bacterial Growth but Affects Cell Viability

Microorganisms
Bacterial ubiquitous Toxin-Antitoxin (TA) systems are considered to be important survival mechanisms during stress conditions. In regular environmental conditions, the antitoxin blocks the toxin, whereas during imbalanced conditions, the antitoxin ...
Deborah K. Damiano, Bruna O. P. Azevedo, George S. C. Fernandes, Aline F. Teixeira, Viviane M. Gonçalves, Ana L. T. O. Nascimento, Alexandre P. Y. Lopes   +6 more
doaj   +1 more source

The ng_ζ1 toxin of the gonococcal epsilon/zeta toxin/antitoxin system drains precursors for cell wall synthesis

Nature Communications, 2018
Toxin–antitoxin (TA) systems are important modulators of bacterial physiology. Here, the authors structurally characterize the epsilon/zeta TA system from the Gram-negative pathogen Neisseria gonorrhoeae and show that the toxin interferes with ...
Andrea Rocker, Madeleine Peschke, Tiia Kittilä, Roman Sakson, Clara Brieke, Anton Meinhart   +5 more
doaj   +1 more source

Novel type II toxin-antitoxin systems with VapD-like proteins

mBio
Type II toxin-antitoxin (TA) systems are widespread in prokaryotes. They consist of neighboring genes encoding two small proteins: a toxin that inhibits a critical cellular process and an antitoxin that binds to and neutralizes the toxin.
Konstantin Gilep, Dmitry Bikmetov, Aleksandr Popov, Anastasiia Rusanova, Shunsuke Tagami, Svetlana Dubiley, Konstantin Severinov   +6 more
doaj   +1 more source

Structural and functional characterization of VapBC52 toxin-antitoxin system from Mycobacterium tuberculosis. [PDF]

Nucleic Acids Res
Singh M, Singh C, Nair AV, Ahmad I, Sharma A, Bhasin M, Jain V, Singh R, Thakur KG.   +8 more
europepmc   +1 more source