Results 71 to 80 of about 18,233,686 (171)

Biomolecular Interaction Prediction in the Pre‐ and Post‐AlphaFold Era: The 8th CAPRI Evaluation

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 11, Page 1813-1826, November 2026.
ABSTRACT We report on the 8th CAPRI Evaluation period, capturing the assessment of CAPRI Rounds 47 to 55 (excluding the CASP and COVID‐related Rounds), which have witnessed the transition to AI‐driven prediction tools such as AlphaFold and related alternatives. The prediction Rounds in this evaluation are characterized by a high level of difficulty due
Marc F. Lensink, Nessim Raouraoua, Guillaume Brysbaert, Sameer Velankar, Shoshana J. Wodak, Alexandre M. J. J. Bonvin   +5 more
wiley   +1 more source

The MazEF Toxin-Antitoxin System Alters the β-Lactam Susceptibility of Staphylococcus aureus. [PDF]

PLoS ONE, 2015
Toxin-antitoxin (TA) systems are genetic elements of prokaryotes which encode a stable toxin and an unstable antitoxin that can counteract toxicity. TA systems residing on plasmids are often involved in episomal maintenance whereas those on chromosomes ...
Christopher F Schuster, Lukas Mechler, Nicoletta Nolle, Bernhard Krismer, Marc-Eric Zelder, Friedrich Götz, Ralph Bertram   +6 more
doaj   +1 more source

The Arms Race Between Bacteria and Their Viruses: Update on Phage Countermeasures Against Bacterial Defence Systems

Microbial Biotechnology, Volume 19, Issue 11, November 2026.
Bacteria evolved anti‐phage systems such as Gabija defence that degrade the intracellular phage genome. Phages evolved counter‐defences such as the Gad1 protein which surrounds and inhibits the Gabija defence complex allowing phage replication. Many cases of phage anti‐defences were recently described.
Harald Brüssow
wiley   +1 more source

Intrinsic Disorder as a New Frontier in Antimicrobial Resistance and Bacterial Fitness

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
The works examines the link between intrinsic disorder in bacterial protein structure, and bacterial function, and antimicrobial resistance. It highlights how flexible, disordered proteins support secretion, stress responses, desiccation protection, and virulence, while also suggesting that these adaptable regions may provide novel targets for ...
Jack O' Callaghan, Michael P. Ryan, Sarah Hudson, Damien Thompson   +3 more
wiley   +1 more source

Mechanistic insights into HipA‐mediated bacterial persistence: Role of initial cellular states and toxin expression kinetics

mLife, Volume 5, Issue 5, Page 651-664, October 2026.
Abstract Persistent bacteria subpopulations showing multidrug tolerance pose significant challenges to antibiotic therapy. While the HipBA toxin–antitoxin (TA) system is known to play a role in persister formation, existing studies predominantly focus on its kinase activity and intracellular regulatory pathways, with limited attention to the ...
Jing Zhao, Yixiao Xiong, Hongxia Zhao, Jin Wang, Xiaona Fang   +4 more
wiley   +1 more source

Toxin-antitoxin Systems: Classification, Biological Function and Application in Biotechnology

, 2014
The toxin-antitoxin (TA) systems are systems in which an unstable antitoxin inhibits a stable toxin. This review aims to introduce the TA system and its biological application in bacteria.
Raftari, M., Sekawi, Z., Sadeghifard, N., Ghafourian, S.   +3 more
core   +1 more source

Toxin-Antitoxin Systems: A Key Role on Persister Formation in Salmonella enterica Serovar Typhimurium

Infection and Drug Resistance, 2022
Made Rai Dwitya Wiradiputra,1,2 Piyatip Khuntayaporn,1,3 Krit Thirapanmethee,1,3 Mullika Traidej Chomnawang1,3 1Antimicrobial Resistance Interdisciplinary Group (AmRIG), Faculty of Pharmacy, Mahidol University, Bangkok, Thailand; 2Biopharmaceutical ...
Wiradiputra MRD, Khuntayaporn P, Thirapanmethee K, Chomnawang MT   +3 more
doaj  

A competence-regulated toxin-antitoxin system in Haemophilus influenzae.

PLoS ONE, 2020
Natural competence allows bacteria to respond to environmental and nutritional cues by taking up free DNA from their surroundings, thus gaining both nutrients and genetic information.
Hailey Findlay Black, Scott Mastromatteo, Sunita Sinha, Rachel L Ehrlich, Corey Nislow, Joshua Chang Mell, Rosemary J Redfield   +6 more
doaj   +1 more source

A Retrospective Descriptive Analysis of Consultations Provided by the National Poisons Centre Relating to Medicines on the Aotearoa New Zealand Antidote Stocking Guideline, 2020–2025

Emergency Medicine Australasia, Volume 38, Issue 5, October 2026.
ABSTRACT Objective Many antidotes are relatively rare‐use, indication‐specific medicines with a variable evidence base. In Aotearoa New Zealand, there are no national statistics available on their use. This study aimed to characterize the numbers of cases and advice provided by the Aotearoa New Zealand National Poisons Centre (NZNPC) on the use of true
Eeva‐Katri Kumpula, William Boroughf
wiley   +1 more source

Shutoff of host transcription triggers a toxin-antitoxin system to cleave phage RNA and abort infection

, 2021
Toxin-antitoxin (TA) systems are widespread in bacteria, but their activation mechanisms and bona fide targets remain largely unknown. Here, we characterize a type III TA system, toxIN, that protects E. coli against multiple bacteriophages, including T4.
Laub, Michael T, Guegler, Chantal K, Guegler, Chantal K., Laub, Michael T., Michael T. Laub, Chantal K. Guegler   +5 more
core   +1 more source