Results 91 to 100 of about 18,233,686 (171)

HEPN-MNT Toxin-Antitoxin System: The HEPN Ribonuclease Is Neutralized by OligoAMPylation

, 2021
Prokaryotic toxin-antitoxin (TA) systems are composed of a toxin capable of interfering with key cellular processes and its neutralizing antidote, the antitoxin. Here, we focus on the HEPN-MNT TA system encoded in the vicinity of a subtype I-D CRISPR-Cas
Songailiene, Inga, Šulčius, Sigitas, Siksnys, Virginijus, Sasnauskas, Giedrius, Tamulaitiene, Giedre, Juozapaitis, Jonas, Venclovas, Česlovas, Ruksenaite, Audrone   +7 more
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A common origin for the bacterial toxin-antitoxin systems parD and ccd, suggested by analyses of toxin/target and toxin/antitoxin interactions.

PLoS ONE, 2012
Bacterial toxin-antitoxin (TA) systems encode two proteins, a potent inhibitor of cell proliferation (toxin) and its specific antidote (antitoxin). Structural data has revealed striking similarities between the two model TA toxins CcdB, a DNA gyrase ...
Andrew B Smith, Juan López-Villarejo, Elizabeth Diago-Navarro, Lesley A Mitchenall, Arjan Barendregt, Albert J Heck, Marc Lemonnier, Anthony Maxwell, Ramón Díaz-Orejas   +8 more
doaj   +1 more source

Mechanisms for Differential Protein Production in Toxin–Antitoxin Systems [PDF]

, 2017
Toxin–antitoxin (TA) systems are key regulators of bacterial persistence, a multidrug-tolerant state found in bacterial species that is a major contributing factor to the growing human health crisis of antibiotic resistance. Type II TA systems consist of
Nicholas C. Butzin, Jensen, Roderick V., Mather, William H., William Mather, Roderick V. Jensen, Heather S. Deter, Heather Deter, William H. Mather, Deter, Heather S., Nicholas Butzin, Butzin, Nicholas C., Roderick Jensen   +11 more
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Autoregulation of bacterial gene expression: lessons from the MazEF toxin-antitoxin system [PDF]

, 2019
Autoregulation is the direct modulation of gene expression by the product of the corresponding gene. Autoregulation of bacterial gene expression has been mostly studied at the transcriptional level, when a protein acts as the cognate transcriptional ...
Nikolic, Nela, Nikolic, Nela ; https://orcid.org/   +1 more
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Development of an antibiotic marker-free platform for heterologous protein production in Streptomyces

Microbial Cell Factories, 2017
Background The industrial use of enzymes produced by microorganisms is continuously growing due to the need for sustainable solutions. Nevertheless, many of the plasmids used for recombinant production of proteins in bacteria are based on the use of ...
Laura Sevillano, Margarita Díaz, Ramón I. Santamaría   +2 more
doaj   +1 more source

The Toxin of VapBC-1 Toxin-Antitoxin Module from Leptospira interrogans Is a Ribonuclease That Does Not Arrest Bacterial Growth but Affects Cell Viability

Microorganisms
Bacterial ubiquitous Toxin-Antitoxin (TA) systems are considered to be important survival mechanisms during stress conditions. In regular environmental conditions, the antitoxin blocks the toxin, whereas during imbalanced conditions, the antitoxin ...
Deborah K. Damiano, Bruna O. P. Azevedo, George S. C. Fernandes, Aline F. Teixeira, Viviane M. Gonçalves, Ana L. T. O. Nascimento, Alexandre P. Y. Lopes   +6 more
doaj   +1 more source

Phages carry orphan antitoxin-like enzymes to neutralize the DarTG1 toxin-antitoxin defense system [PDF]

The astounding number of anti-phage defenses encoded by bacteria is countered by an elaborate set of phage counter-defenses, though their evolutionary origins are often unknown. Here, we report the discovery of an orphan antitoxin counter-defense element
Johannesman, Anna, Carlson, Nico, Awasthi, Leila C, LeRoux, Michele   +3 more
core   +1 more source

Type II toxin: antitoxin systems. More than small selfish entities?

, 2016
Toxin-antitoxin (TA) modules regulate metabolism and viability of bacteria and archaea. In type II TA systems these functions are generally thought to be performed by two small proteins.
Rocker, A., Meinhart, A.
core   +1 more source

The ng_ζ1 toxin of the gonococcal epsilon/zeta toxin/antitoxin system drains precursors for cell wall synthesis

Nature Communications, 2018
Toxin–antitoxin (TA) systems are important modulators of bacterial physiology. Here, the authors structurally characterize the epsilon/zeta TA system from the Gram-negative pathogen Neisseria gonorrhoeae and show that the toxin interferes with ...
Andrea Rocker, Madeleine Peschke, Tiia Kittilä, Roman Sakson, Clara Brieke, Anton Meinhart   +5 more
doaj   +1 more source

Metal dependency of HP0892 toxin from Helicobacter pylori HP0892-HP0893 Toxin-Antitoxin system

, 2012
학위논문 (석사)-- 서울대학교 대학원 : 약학과, 2012. 2. 이봉진.Helicobacter pylori are helix-shaped, gram-negative, microaerophilic bacteria. It can survive in the extreme acidic environment, colonize to the stomach's epithelial cell layer.
양연진
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