Results 11 to 20 of about 9,494,692 (194)
Biology and Evolution of Bacterial Toxin–Antitoxin Systems [PDF]
Nature Reviews Microbiology, 2022 Toxin–antitoxin systems are widespread in bacterial genomes. They are usually composed of two elements: a toxin that inhibits an essential cellular process and an antitoxin that counteracts its cognate toxin.
Nathan Fraikin +2 more
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Chaperone addiction of toxin–antitoxin systems [PDF]
Nature Communications, 2016 Some bacterial toxin-antitoxin systems consist of a labile antitoxin that inhibits a toxin, and a chaperone that stabilizes the antitoxin. Here, Bordes et al.
Patricia Bordes +8 more
doaj +4 more sources
Toxin-Antitoxin Systems as Multilevel Interaction Systems [PDF]
Toxins, 2014 Toxin-antitoxin (TA) systems are small genetic modules usually composed of a toxin and an antitoxin counteracting the activity of the toxic protein. These systems are widely spread in bacterial and archaeal genomes.
Nathalie Goeders, Laurence Van Melderen
doaj +5 more sources
Toxin–Antitoxin Systems in Bacillus subtilis [PDF]
Toxins, 2019 Toxin−antitoxin (TA) systems were originally discovered as plasmid maintenance systems in a multitude of free-living bacteria, but were afterwards found to also be widespread in bacterial chromosomes.
Sabine Brantl, Peter Müller
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Toxin-Antitoxin Systems as Phage Defense Elements
Annual Review of Microbiology, 2022 Toxin-antitoxin (TA) systems are ubiquitous genetic elements in bacteria that consist of a growth-inhibiting toxin and its cognate antitoxin. These systems are prevalent in bacterial chromosomes, plasmids, and phage genomes, but individual systems are ...
Laub MT, Michele Leroux
exaly +5 more sources
Structural insights into chaperone addiction of toxin-antitoxin systems [PDF]
Nature Communications, 2019 SecB homologs can be associated with stress-responsive type II toxin–antitoxin (TA) systems and form tripartite toxin-antitoxin-chaperone systems (TAC).
Valérie Guillet +12 more
doaj +5 more sources
An oxygen-sensitive toxin–antitoxin system [PDF]
Nature Communications, 2016 Classical toxin–antitoxin systems in bacteria are based on silencing of a toxin by an antitoxin that, when inactivated, releases the toxin, resulting in a change in metabolism. Here, the authors characterize an oxygen-sensitive toxin–antitoxin system and
Oriol Marimon +13 more
doaj +7 more sources
Regulation of toxin-antitoxin systems by proteolysis. [PDF]
Plasmid, 2013 Toxin-antitoxin systems are widely distributed among many bacterial species, including human pathogens. Regulation of type II TA system functions, where both components are proteins, relies on proteolysis.
Brzozowska, Iwona +1 more
core +5 more sources
Mobile Genetic Elements, 2013 Toxin-antitoxin (TA) systems are small genetic elements composed of a toxin gene and its cognate antitoxin. The toxins of all known TA systems are proteins while the antitoxins are either proteins or non-coding RNAs. Based on the molecular nature of the antitoxin and its mode of interaction with the toxin the TA modules are currently grouped into five ...
Simon J Unterholzner +2 more
exaly +3 more sources
Mechanisms for Differential Protein Production in Toxin–Antitoxin Systems [PDF]
Toxins, 2017 Toxin–antitoxin (TA) systems are key regulators of bacterial persistence, a multidrug-tolerant state found in bacterial species that is a major contributing factor to the growing human health crisis of antibiotic resistance. Type II TA systems consist of
Heather S. Deter +3 more
doaj +2 more sources