Results 11 to 20 of about 16,375 (172)
Chaperone addiction of toxin–antitoxin systems [PDF]
Nature Communications, 2016 Some bacterial toxin-antitoxin systems consist of a labile antitoxin that inhibits a toxin, and a chaperone that stabilizes the antitoxin. Here, Bordes et al.
Patricia Bordes +8 more
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Toxin-Antitoxin Systems as Multilevel Interaction Systems [PDF]
Toxins, 2014 Toxin-antitoxin (TA) systems are small genetic modules usually composed of a toxin and an antitoxin counteracting the activity of the toxic protein. These systems are widely spread in bacterial and archaeal genomes.
Nathalie Goeders, Laurence Van Melderen
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Toxin–Antitoxin Systems in Bacillus subtilis [PDF]
Toxins, 2019 Toxin−antitoxin (TA) systems were originally discovered as plasmid maintenance systems in a multitude of free-living bacteria, but were afterwards found to also be widespread in bacterial chromosomes.
Sabine Brantl, Peter Müller
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An oxygen-sensitive toxin–antitoxin system [PDF]
Nature Communications, 2016 Classical toxin–antitoxin systems in bacteria are based on silencing of a toxin by an antitoxin that, when inactivated, releases the toxin, resulting in a change in metabolism. Here, the authors characterize an oxygen-sensitive toxin–antitoxin system and
Oriol Marimon +13 more
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Toxin-Antitoxin Systems of Staphylococcus aureus [PDF]
Toxins, 2016 Toxin-antitoxin (TA) systems are small genetic elements found in the majority of prokaryotes. They encode toxin proteins that interfere with vital cellular functions and are counteracted by antitoxins. Dependent on the chemical nature of the antitoxins (protein or RNA) and how they control the activity of the toxin, TA systems are currently divided ...
Christopher Schuster, Ralph Bertram
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RNA Regulated Toxin-Antitoxin Systems in Pathogenic Bacteria [PDF]
Frontiers in Cellular and Infection Microbiology, 2021 The dynamic host environment presents a significant hurdle that pathogenic bacteria must overcome to survive and cause diseases. Consequently, these organisms have evolved molecular mechanisms to facilitate adaptation to environmental changes within the ...
David D. Sarpong +5 more
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Bacterial toxin-antitoxin systems [PDF]
Mobile Genetic Elements, 2011 Toxin-antitoxin (TA) systems are composed of two elements: a toxic protein and an antitoxin which is either an RNA (type I and III) or a protein (type II). Type II systems are abundant in bacterial genomes in which they move via horizontal gene transfer.
Guglielmini, Julien +1 more
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Structural insights into chaperone addiction of toxin-antitoxin systems [PDF]
Nature Communications, 2019 SecB homologs can be associated with stress-responsive type II toxin–antitoxin (TA) systems and form tripartite toxin-antitoxin-chaperone systems (TAC).
Valérie Guillet +12 more
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Toxin-Antitoxin Systems: Implications for Plant Disease [PDF]
Annual Review of Phytopathology, 2017 Toxin-antitoxin (TA) systems are gene modules that are ubiquitous in free-living prokaryotes. Diverse in structure, cellular function, and fitness roles, TA systems are defined by the presence of a toxin gene that suppresses bacterial growth and a toxin-neutralizing antitoxin gene, usually encoded in a single operon.
T, Shidore, L R, Triplett
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Toxin–antitoxin systems: reversible toxicity [PDF]
Current Opinion in Microbiology, 2017 Toxin-antitoxin (TA) systems encoded on the plasmids and chromosomes of bacteria are emerging as key players in stress adaptation. In particular, they have been implicated in the induction of persisters non-growing cells that can evade antibiotic exposure.
Hall, A, Gollan, B, Helaine, S
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