Results 31 to 40 of about 9,494,692 (194)

Insights into toxin-antitoxin systems in the genus <i>Bifidobacterium</i>. [PDF]

Appl Environ Microbiol
ABSTRACT Toxin-antitoxin (TA) systems are widespread genetic modules in prokaryotes, implicated in diverse functions including stress adaptation, genome stability, and virulence. While extensively studied in pathogenic bacteria, their presence and roles in beneficial gut
Lefimil C, Bustamante P.
europepmc   +3 more sources

Toxin-Antitoxin Systems in Clinical Pathogens [PDF]

Toxins, 2016
Toxin-antitoxin (TA) systems are prevalent in bacteria and archaea. Although not essential for normal cell growth, TA systems are implicated in multiple cellular functions associated with survival under stress conditions. Clinical strains of bacteria are currently causing major human health problems as a result of their multidrug resistance ...
Fernández-García, Laura, Blasco, Lucía, López, María, Bou, Germán, García-Contreras, Rodolfo, Wood, Thomas, Tomás, María   +6 more
openaire   +5 more sources

Editorial for Special Issue "Bacterial Toxin-Antitoxin Systems". [PDF]

Microorganisms
Toxin antitoxin systems (TAS) are widely distributed in bacterial chromosomes as well as on mobile genetic elements [...
Kamruzzaman M.
europepmc   +2 more sources

Rapid Identification of Secondary Structure and Binding Site Residues in an Intrinsically Disordered Protein Segment

Frontiers in Genetics, 2021
Mycobacterium tuberculosis harbours nine toxin-antitoxin (TA) systems of the MazEF family. MazEF TA modules are of immense importance due to the perceived role of the MazF toxin in M. tuberculosis persistence and disease.
Soumyanetra Chandra, Gopinath Chattopadhyay, Raghavan Varadarajan   +2 more
doaj   +1 more source

The coevolution of toxin and antitoxin genes drives the dynamics of bacterial addiction complexes and intragenomic conflict [PDF]

, 2012
Bacterial genomes commonly contain 'addiction' gene complexes that code for both a toxin and a corresponding antitoxin. As long as both genes are expressed, cells carrying the complex can remain healthy.
Rankin, Daniel J., Leighton A. Turner, Daniel J. Rankin, Heinemann, Jack A., Brown, Sam P., Sam P. Brown, Turner, Leighton A., Jack A. Heinemann, Turner LA, Brown SP, Heinemann JA, Rankin DJ   +11 more
core   +1 more source

Toxin-antitoxin cassettes identified by TA finder in investigated Salmonella strains with functional classification of candidate toxin and antitoxin proteins.

, 2021
Toxin-antitoxin cassettes identified by TA finder in investigated Salmonella strains with functional classification of candidate toxin and antitoxin proteins.
Taruna Anand (828898), Rajesh Kumar Vaid (11302529), Bhupendra Nath Tripathi (9032255), Zoozeal Thakur (11302532), Sanjay Kumar (8853)   +4 more
core   +1 more source

Minigene as a Novel Regulatory Element in Toxin-Antitoxin Systems [PDF]

International Journal of Molecular Sciences, 2021
The axe-txe type II toxin-antitoxin (TA) system is characterized by a complex and multilayered mode of gene expression regulation. Precise and tight control of this process is crucial to keep the toxin in an appropriate balance with the cognate antitoxin until its activation is needed for the cell.
Barbara Kędzierska, Katarzyna Potrykus
openaire   +2 more sources

Crystal Structure of the Escherichia coli Fic Toxin-Like Protein in Complex with Its Cognate Antitoxin [PDF]

, 2016
FIC domain proteins mediate post-translational modifications of target proteins, which typically results in their inactivation. Depending on the conservation of crucial active site residues, the FIC fold serves as structural scaffold for various ...
Stanger, Frédéric V., Frédéric V Stanger, Tilman Schirmer, Alexander Harms (3132942), Dehio, Christoph, Harms, Alexander, Schirmer, Tilman, Christoph Dehio, Frédéric V. Stanger (585551), Alexander Harms, Tilman Schirmer (585552), Christoph Dehio (200951), Harms A, Stanger, Frédéric V. (author), Harms, Alexander; id_orcid, Dehio, Christoph (author), Schirmer T, Stanger FV, Schirmer, Tilman (author), Dehio C, Harms, Alexander (author)   +20 more
core   +2 more sources

Bacterial retrons encode phage-defending tripartite toxin-antitoxin systems. [PDF]

Nature, 2022
Bobonis J, Mitosch K, Mateus A, Karcher N, Kritikos G, Selkrig J, Zietek M, Monzon V, Pfalz B, Garcia-Santamarina S, Galardini M, Sueki A, Kobayashi C, Stein F, Bateman A, Zeller G, Savitski MM, Elfenbein JR, Andrews-Polymenis HL, Typas A.   +19 more
europepmc   +2 more sources

Conditional cooperativity of toxin - antitoxin regulation can mediate bistability between growth and dormancy. [PDF]

PLoS Computational Biology, 2013
Many toxin-antitoxin operons are regulated by the toxin/antitoxin ratio by mechanisms collectively coined "conditional cooperativity". Toxin and antitoxin form heteromers with different stoichiometric ratios, and the complex with the intermediate ratio ...
Ilaria Cataudella, Kim Sneppen, Kenn Gerdes, Namiko Mitarai   +3 more
doaj   +1 more source