Results 31 to 40 of about 16,346 (193)

Type I toxin-antitoxin systems in bacteria: from regulation to biological functions. [PDF]

EcoSal Plus
Shore SFH, Leinberger FH, Fozo EM, Berghoff BA.   +3 more
europepmc   +2 more sources

The coevolution of toxin and antitoxin genes drives the dynamics of bacterial addiction complexes and intragenomic conflict [PDF]

, 2012
Bacterial genomes commonly contain 'addiction' gene complexes that code for both a toxin and a corresponding antitoxin. As long as both genes are expressed, cells carrying the complex can remain healthy.
Rankin, Daniel J., Leighton A. Turner, Daniel J. Rankin, Heinemann, Jack A., Brown, Sam P., Sam P. Brown, Turner, Leighton A., Jack A. Heinemann   +7 more
core   +1 more source

Crystal Structure of the Escherichia coli Fic Toxin-Like Protein in Complex with Its Cognate Antitoxin [PDF]

, 2016
FIC domain proteins mediate post-translational modifications of target proteins, which typically results in their inactivation. Depending on the conservation of crucial active site residues, the FIC fold serves as structural scaffold for various ...
Stanger, Frédéric V., Frédéric V Stanger, Tilman Schirmer, Alexander Harms (3132942), Dehio, Christoph, Harms, Alexander, Schirmer, Tilman, Christoph Dehio, Frédéric V. Stanger (585551), Alexander Harms, Tilman Schirmer (585552), Christoph Dehio (200951)   +11 more
core   +1 more source

The vapB-vapC operon of Acidovorax citrulli functions as a bona-fide toxin-antitoxin module

Frontiers in Microbiology, 2016
Toxin–antitoxin systems are commonly found on plasmids and chromosomes of bacteria and archaea. These systems appear as biscystronic genes encoding a stable toxin and a labile antitoxin, which protects the cells from the toxin’s activity. Under specific,
Reut eShavit, Mario eLebendiker, Zohar ePasternak, Saul eBurdman, Yael eHelman   +4 more
doaj   +1 more source

Conditional cooperativity of toxin - antitoxin regulation can mediate bistability between growth and dormancy. [PDF]

PLoS Computational Biology, 2013
Many toxin-antitoxin operons are regulated by the toxin/antitoxin ratio by mechanisms collectively coined "conditional cooperativity". Toxin and antitoxin form heteromers with different stoichiometric ratios, and the complex with the intermediate ratio ...
Ilaria Cataudella, Kim Sneppen, Kenn Gerdes, Namiko Mitarai   +3 more
doaj   +1 more source

Minimalistic mycoplasmas harbor different functional toxin-antitoxin systems [PDF]

, 2021
Mycoplasmas are minute bacteria controlled by very small genomes ranging from 0.6 to 1.4 Mbp. They encompass several important medical and veterinary pathogens that are often associated with a wide range of chronic diseases.
Sánchez Barbarroja, Rubén, Stoffel, Michael H., Jores, Joerg, Barbarroja, Rubén Sánchez, Akarsu, Hatice, Cippà, Valentina L., Heller, Martin, Labroussaa, Fabien, Kuhnert, Peter, Hill, Virginia, Falquet, Laurent, Heller, Manfred   +11 more
core   +1 more source

Editorial for Special Issue "Bacterial Toxin-Antitoxin Systems". [PDF]

Microorganisms
Toxin antitoxin systems (TAS) are widely distributed in bacterial chromosomes as well as on mobile genetic elements [...
Kamruzzaman M.
europepmc   +2 more sources

PrrT/A, a Pseudomonas aeruginosa Bacterial Encoded Toxin-Antitoxin System Involved in Prophage Regulation and Biofilm Formation

Microbiology Spectrum, 2022
Toxin-antitoxin (TA) systems are genetic modules that consist of a stable protein-toxin and an unstable antitoxin that neutralizes the toxic effect. In type II TA systems, the antitoxin is a protein that inhibits the toxin by direct binding.
Esther Shmidov, Ilana Lebenthal-Loinger, Shira Roth, Sarit Karako-Lampert, Itzhak Zander, Sivan Shoshani, Amos Danielli, Ehud Banin   +7 more
doaj   +1 more source

Type II Toxin-Antitoxin Systems in Escherichia coli. [PDF]

Infect Drug Resist
The toxin-antitoxin (TA) system is widespread in prokaryotes and archaea, comprising toxins and antitoxins that counterbalance each other. Based on the nature and mode of action of antitoxins, they are classified into eight groups (type I to VIII). Both the toxins and the antitoxins are proteins in type II TA systems, and the antitoxin gene is usually ...
Zhang H, Tao S, Chen H, Fang Y, Xu Y, Han AX, Ma F, Liang W.   +7 more
europepmc   +5 more sources

Hypothetical Functions of Toxin-Antitoxin Systems [PDF]

Journal of Bacteriology, 2007
Toxin-antitoxin systems are very commonly found both on large, low-copy plasmids, where they increase effective stability ([35][1]), and on bacterial chromosomes, where their function has been the subject of considerable speculation.
openaire   +2 more sources