Results 51 to 60 of about 9,494,692 (194)

The Cysteine Protease MaOC1, a Prokaryotic Caspase Homolog, Cleaves the Antitoxin of a Type II Toxin-Antitoxin System

Frontiers in Microbiology, 2021
The bloom-forming cyanobacterium Microcystis aeruginosa is known for its global distribution and for the production of toxic compounds. In the genome of M.
Marina Klemenčič, Ana Halužan Vasle, Marko Dolinar   +2 more
doaj   +1 more source

Prevalence of Fst-like toxin–antitoxin systems [PDF]

Microbiology, 2010
Toxin–antitoxin (TA) systems are widespread in Gram-negative bacteria, and all systems identified to date encode a toxic protein and an unstable antitoxin, which may be in the form of either an antisense RNA (type I) or a second protein (type II). The enterococcal plasmid pAD1-encoded TA system (par), encoding the Fst toxin, was the first type I TA ...
Kwong, Stephen M. (R20881), Jensen, Slade O., Firth, Neville   +2 more
openaire   +3 more sources

Evaluating the Potential for Cross-Interactions of Antitoxins in Type II TA Systems

Toxins, 2020
The diversity of Type-II toxin–antitoxin (TA) systems in bacterial genomes requires tightly controlled interaction specificity to ensure protection of the cell, and potentially to limit cross-talk between toxin–antitoxin pairs of the same family of TA ...
Chih-Han Tu, Michelle Holt, Shengfeng Ruan, Christina Bourne   +3 more
doaj   +1 more source

A toxin-deformation dependent inhibition mechanism in the T7SS toxin-antitoxin system of Gram-positive bacteria

Nature Communications, 2022
Antimicrobial toxins are secreted by bacteria to kill rival species. Here the authors report the mechanism of inhibition of EsaD, a toxin secreted by some S.
Yongjin Wang, Yang Zhou, Chaowei Shi, Jiacong Liu, Guohua Lv, Huisi Huang, Shengrong Li, Liping Duan, Xinyi Zheng, Yue Liu, Haibo Zhou, Yonghua Wang, Zhengqiu Li, Ke Ding, Pinghua Sun, Yun Huang, Xiaoyun Lu, Zhi-Min Zhang   +17 more
doaj   +1 more source

To be or not to be: regulation of restriction–modification systems and other toxin–antitoxin systems [PDF]

Nucleic Acids Research, 2013
One of the simplest classes of genes involved in programmed death is that containing the toxin-antitoxin (TA) systems of prokaryotes. These systems are composed of an intracellular toxin and an antitoxin that neutralizes its effect. These systems, now classified into five types, were initially discovered because some of them allow the stable ...
Iwona Mruk, Kobayashi, Ichizo
openaire   +2 more sources

Structural Basis of Shiga Toxin Neutralization by Human Antibodies Targeting Canonical Receptor‐Binding and Non‐Canonical Assembly Sites

Advanced Science, EarlyView.
Cryo‐electron microscopy structures reveal two distinct neutralization mechanisms of fully human monoclonal antibodies targeting the Shiga toxin 1a B subunit. RDS059 occludes the Gb3 receptor‐binding site, whereas RDS045 engages a lateral quaternary epitope to disrupt holotoxin assembly.
Jianting Ke, Xin Li, Xiaoli Wang, Zhaoxia Huang, Shaojie Xue, Yuyang Liu, Jing Pan, Guowei Hu, Yayu Wang, Cheng Wang, Shoudeng Chen   +10 more
wiley   +1 more source

Cryo-EM reveals the quaternary architecture of TenpIN type III toxin-antitoxin RNP complex common to pathogenic bacteria.

PLoS Pathogens
Type III toxin-antitoxin (TA) systems are anti-phage defense systems in bacteria that comprises a protein toxin and a cognate non-coding RNA antitoxin. Under normal conditions, the antitoxin binds and inhibits the toxin.
Kavyashree Nadig, Surekha Padmanaban, Salik Noor, Sankaran Sandhya, Parthasarathy Manikandan, Somnath Dutta, Mahavir Singh   +6 more
doaj   +1 more source

Diverse LXG toxin and antitoxin systems specifically mediate intraspecies competition in Bacillus subtilis biofilms.

PLoS Genetics, 2021
Biofilms are multispecies communities, in which bacteria constantly compete with one another for resources and niches. Bacteria produce many antibiotics and toxins for competition.
Kazuo Kobayashi
doaj   +1 more source

The Collective Power of Bacteria as a Blueprint for Emergent Intelligence

Advanced Intelligent Systems, EarlyView.
Small cells, powerful collectives. Bacteria demonstrate how sophisticated behaviors can emerge from many simple individuals working together. We explore the remarkable world of bacterial communities and the mechanisms that underpin their complex emergent behaviors, enabling impressive adaptability, robustness, and responsiveness to changing ...
Johanna A. Blee, Thomas E. Gorochowski, Sabine Hauert   +2 more
wiley   +1 more source

Vaginal host–microbe signatures linked to placental outcomes in mares

Equine Veterinary Journal, EarlyView.
Abstract Background Ascending placentitis is a leading cause of late‐term pregnancy loss in mares. Although pathogens are presumed to ascend from the caudal reproductive tract, the association between the vaginal microbiome and placentitis has not been systematically examined.
Machteld van Heule, Babiche Heil, Jamie K. Norris, Kristene Gedye, Xiaoxiao Lin, Ward De Spiegelaere, Peter Daels, Pouya Dini   +7 more
wiley   +1 more source