Results 51 to 60 of about 16,375 (172)
Evaluating the Potential for Cross-Interactions of Antitoxins in Type II TA Systems
Toxins, 2020 The diversity of Type-II toxin–antitoxin (TA) systems in bacterial genomes requires tightly controlled interaction specificity to ensure protection of the cell, and potentially to limit cross-talk between toxin–antitoxin pairs of the same family of TA ...
Chih-Han Tu +3 more
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Toxin-Antitoxin Systems: Classification, Biological Function and Application in Biotechnology [PDF]
, 2013 The toxin-antitoxin (TA) systems are systems in which an unstable antitoxin inhibits a stable toxin. This review aims to introduce the TA system and its biological application in bacteria. For this purpose, first we introduce a new classification for the
Sobhan Ghafourian +3 more
core +1 more source
Nature Communications, 2022 Antimicrobial toxins are secreted by bacteria to kill rival species. Here the authors report the mechanism of inhibition of EsaD, a toxin secreted by some S.
Yongjin Wang +17 more
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To be or not to be: regulation of restriction–modification systems and other toxin–antitoxin systems [PDF]
Nucleic Acids Research, 2013 One of the simplest classes of genes involved in programmed death is that containing the toxin-antitoxin (TA) systems of prokaryotes. These systems are composed of an intracellular toxin and an antitoxin that neutralizes its effect. These systems, now classified into five types, were initially discovered because some of them allow the stable ...
Iwona Mruk, Kobayashi, Ichizo
openaire +2 more sources
Toxin-antitoxin systems and its biotechnological applications [PDF]
, 2014 Toxin-antitoxin (TA) systems are important genetic modules composed by two elements: a toxin, that is always a protein, and an antitoxin, that can be a RNA or a protein and neutralizes the toxic effect of toxin.
Cangussu, Alex Sânder Rodrigues +5 more
core +1 more source
Molecular and Structural Basis of Cross-Reactivity in M. tuberculosis Toxin–Antitoxin Systems
Toxins, 2020 Mycobacterium tuberculosis genome encodes over 80 toxin–antitoxin (TA) systems. While each toxin interacts with its cognate antitoxin, the abundance of TA systems presents an opportunity for potential non-cognate interactions. TA systems mediate manifold
Himani Tandon +3 more
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Bacterial retrons encode phage-sensing toxin/antitoxin systems [PDF]
, 2022 Retrons are prokaryotic genetic systems containing reverse transcriptases (RTs) that produce multiple copies of small single-stranded DNA (msDNA). Despite our understanding of the complex msDNA biosynthesis, the physiological role of retrons has ...
Bomponis, Iakovos
core +1 more source
PLoS Genetics, 2021 Biofilms are multispecies communities, in which bacteria constantly compete with one another for resources and niches. Bacteria produce many antibiotics and toxins for competition.
Kazuo Kobayashi
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IUCrJ, 2022 Type II toxin–antitoxin (TA) systems encode two proteins: a toxin that inhibits cell growth and an antitoxin that neutralizes the toxin by direct intermolecular protein–protein interactions.
Ji Sung Koo +4 more
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BMC Genomics, 2006 Background Post-segregational killing systems are present in a large variety of microorganisms. When found on plasmids, they are described as addiction systems that act to maintain the plasmid during the partitioning of the cell.
Mahillon Jacques, Fico Sarah
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