Results 71 to 80 of about 16,375 (172)

Keeping the wolves at bay: antitoxins of prokaryotic type II toxin-antitoxin systems

Frontiers in Molecular Biosciences, 2016
In their initial stages of discovery, prokaryotic toxin-antitoxin (TA) systems were confined to bacterial plasmids where they function to mediate the maintenance and stability of usually low- to medium-copy number plasmids through the post-segregational ...
Wai Ting eChan, Manuel eEspinosa, Chew Chieng eYeo   +2 more
doaj   +1 more source

The Biology and Biochemistry of PhoH2 proteins [PDF]

, 2013
PhoH2 proteins are found in a diverse range of organisms. To date little is known about these proteins and the role they play in the organisms in which they reside.
Andrews, Emma Sophie Vout
core  

Unrelated toxin–antitoxin systems cooperate to induce persistence [PDF]

, 2015
Persisters are drug-tolerant bacteria that account for the majority of bacterial infections. They are not mutants, rather, they are slow-growing cells in an otherwise normally growing population.
Savageau, Michael A, Fasani, Rick A
core   +1 more source

Type I Toxin-Antitoxin Systems in Clostridia [PDF]

Toxins, 2019
Type I toxin-antitoxin (TA) modules are abundant in both bacterial plasmids and chromosomes and usually encode a small hydrophobic toxic protein and an antisense RNA acting as an antitoxin. The RNA antitoxin neutralizes toxin mRNA by inhibiting its translation and/or promoting its degradation.
openaire   +4 more sources

Combining cysteine scanning with chemical labeling to map protein-protein interactions and infer bound structure in an intrinsically disordered region

Frontiers in Molecular Biosciences, 2022
The Mycobacterium tuberculosis genome harbours nine toxin-antitoxin (TA) systems of the mazEF family. These consist of two proteins, a toxin and an antitoxin, encoded in an operon.
Shahbaz Ahmed, Gopinath Chattopadhyay, Kavyashree Manjunath, Munmun Bhasin, Neelam Singh, Mubashir Rasool, Sayan Das, Varsha Rana, Neha Khan, Debarghya Mitra, Aparna Asok, Ramandeep Singh, Raghavan Varadarajan   +12 more
doaj   +1 more source

Towards Exploring Toxin-Antitoxin Systems in Geobacillus: A Screen for Type II Toxin-Antitoxin System Families in a Thermophilic Genus

International Journal of Molecular Sciences, 2019
The toxin-antitoxin (TA) systems have been attracting attention due to their role in regulating stress responses in prokaryotes and their biotechnological potential. Much recognition has been given to type II TA system of mesophiles, while thermophiles have received merely limited attention.
Rawana Alkhalili, Joel Wallenius, Björn Canbäck   +2 more
openaire   +2 more sources

RHS-elements function as type II toxin-antitoxin modules that regulate intra-macrophage replication of Salmonella Typhimurium.

PLoS Genetics, 2020
RHS elements are components of conserved toxin-delivery systems, wide-spread within the bacterial kingdom and some of the most positively selected genes known. However, very little is known about how Rhs toxins affect bacterial biology.
Magnus Stårsta, Disa L Hammarlöf, Marcus Wäneskog, Susan Schlegel, Feifei Xu, Arvid Heden Gynnå, Malin Borg, Sten Herschend, Sanna Koskiniemi   +8 more
doaj   +1 more source

Molecular Characterization of SehB, a Type II Antitoxin of Salmonella enterica Serotype Typhimurium: Amino Acid Residues Involved in DNA-Binding, Homodimerization, Toxin Interaction, and Virulence

Frontiers in Microbiology, 2020
Salmonella enterica serotype Typhimurium is a bacterium that causes gastroenteritis and diarrhea in humans. The genome of S. Typhimurium codes for diverse virulence factors, among which are the toxin-antitoxin (TA) systems.
Fernando Chimal-Cázares, Fernando Chimal-Cázares, Gabriela Hernández-Martínez, Gabriela Hernández-Martínez, Sabino Pacheco, Miguel A. Ares, Jorge Soria-Bustos, Jorge Soria-Bustos, Manuel Sánchez-Gutiérrez, Jeannett A. Izquierdo-Vega, Jose Antonio Ibarra, Jorge A. González-y-Merchand, Jean-Pierre Gorvel, Stéphane Méresse, Miguel A. De la Cruz   +14 more
doaj   +1 more source

Identification, characterization, structure, and assembly of type III toxin-antitoxin systems from Escherichia coli [PDF]

, 2021
Bacteria adopt several defense strategies to enable their survival against the environmental threats they encounter from time to time. Toxin-antitoxin (TA) systems are being understood as a key bacterial defense mechanism against invading viruses ...
Manikandan, P
core  

The VapBC-4 Characterization Indicates It Is a Bona Fide Toxin-Antitoxin Module of Leptospira interrogans: Initial Evidence for a Role in Bacterial Adaptation

Microorganisms
Toxin-antitoxin (TA) systems are one of the bacterial adaptation mechanisms to adverse conditions. Leptospira interrogans serovar Copenhageni contains nine putative TA systems.
Bruna Oliveira Pigatto Azevedo, Deborah Kohn Damiano, Aline Florencio Teixeira, Ana Lucia Tabet Oller Nascimento, Luis Guilherme Virgilio Fernandes, Alexandre Paulo Yague Lopes   +5 more
doaj   +1 more source