Results 81 to 90 of about 9,494,692 (194)

Integrative Modeling in the Age of Machine Learning: A Summary of HADDOCK Strategies in CAPRI Rounds 47–55

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 11, Page 1746-1752, November 2026.
ABSTRACT The HADDOCK team participated in CAPRI rounds 47–55 as server, manual predictor, and scorers. Throughout these CAPRI rounds, we used a plethora of computational strategies to predict the structure of protein complexes. Of the 10 targets comprising 24 interfaces, we achieved acceptable or better models for 3 targets in the human category and 1 ...
Victor Reys, Marco Giulini, Vlad Cojocaru, Anna Engel, Xiaotong Xu, Jorge Roel‐Touris, Cunliang Geng, Francesco Ambrosetti, Brian Jiménez‐García, Zuzana Jandova, Panagiotis I. Koukos, Charlotte van Noort, João M. C. Teixeira, Siri C. van Keulen, Manon Réau, Rodrigo V. Honorato, Alexandre M. J. J. Bonvin   +16 more
wiley   +1 more source

Toxin-antitoxin systems predicted in L. pentosus KCA1.

, 2013
Toxin-antitoxin systems predicted in L. pentosus KCA1.
Bernadet Renckens (391864), Kingsley C. Anukam (391863), Jos Boekhorst (81341), Jean M. Macklaim (198176), Gregory B. Gloor (198199), Gregor Reid (163342), Roland J. Siezen (12053), Sacha A. F. T. van Hijum (9843)   +7 more
core   +1 more source

Biomolecular Interaction Prediction in the Pre‐ and Post‐AlphaFold Era: The 8th CAPRI Evaluation

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 11, Page 1813-1826, November 2026.
ABSTRACT We report on the 8th CAPRI Evaluation period, capturing the assessment of CAPRI Rounds 47 to 55 (excluding the CASP and COVID‐related Rounds), which have witnessed the transition to AI‐driven prediction tools such as AlphaFold and related alternatives. The prediction Rounds in this evaluation are characterized by a high level of difficulty due
Marc F. Lensink, Nessim Raouraoua, Guillaume Brysbaert, Sameer Velankar, Shoshana J. Wodak, Alexandre M. J. J. Bonvin   +5 more
wiley   +1 more source

The Arms Race Between Bacteria and Their Viruses: Update on Phage Countermeasures Against Bacterial Defence Systems

Microbial Biotechnology, Volume 19, Issue 11, November 2026.
Bacteria evolved anti‐phage systems such as Gabija defence that degrade the intracellular phage genome. Phages evolved counter‐defences such as the Gad1 protein which surrounds and inhibits the Gabija defence complex allowing phage replication. Many cases of phage anti‐defences were recently described.
Harald Brüssow
wiley   +1 more source

Continuous Evolution System Based on Toxin–Antitoxin System Combined with Base Deaminase Accelerates the In Vivo Modification of Target Proteins

Advanced Science, Volume 13, Issue 59, 23 October 2026.
The promoted Escherichia coli‐assisted continuous evolution (PEACE) system operates through a stringent three step genetic circuit: target gene mutation via a deaminase–T7 RNA polymerase (T7 RNAP) fusion, coupling variant function to antitoxin expression, and growth based selection of surviving cells.
Xinyu Zhang, Zhanzhi Liu, Ying Xu, Mingjing Sun, Guangzhen Zhou, Deming Rao, Xiaoqian Chen, Sheng Wang, Zhigang Li, Yan Huang, Jing Wu   +10 more
wiley   +1 more source

Towards Exploring Toxin-Antitoxin Systems in Geobacillus: A Screen for Type II Toxin-Antitoxin System Families in a Thermophilic Genus

International Journal of Molecular Sciences, 2019
The toxin-antitoxin (TA) systems have been attracting attention due to their role in regulating stress responses in prokaryotes and their biotechnological potential. Much recognition has been given to type II TA system of mesophiles, while thermophiles have received merely limited attention.
Rawana Alkhalili, Joel Wallenius, Björn Canbäck   +2 more
openaire   +2 more sources

Potential role of a CRISPR-Cas-activated toxin-antitoxin system in bacterial immunity

Nature Communications
CRISPR-Cas and toxin-antitoxin systems can serve as antiviral defense mechanisms in prokaryotes. In typical toxin-antitoxin systems, toxin activation can limit phage propagation by inducing growth arrest or reduced cellular fitness, while the antitoxin ...
Jiyun Chen, Linglong Huang, Hong Chen, Xueyan Li, Xiaofeng Lin, Chenmin Guo, Xi Liu, Guowei Fu, Ying Chen, Liang Liu   +9 more
doaj   +1 more source

Intrinsic Disorder as a New Frontier in Antimicrobial Resistance and Bacterial Fitness

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
The works examines the link between intrinsic disorder in bacterial protein structure, and bacterial function, and antimicrobial resistance. It highlights how flexible, disordered proteins support secretion, stress responses, desiccation protection, and virulence, while also suggesting that these adaptable regions may provide novel targets for ...
Jack O' Callaghan, Michael P. Ryan, Sarah Hudson, Damien Thompson   +3 more
wiley   +1 more source

Artificial activation of toxin–antitoxin systems as an antibacterial strategy [PDF]

Trends in Microbiology, 2012
Toxin-antitoxin (TA) systems are unique modules that effect plasmid stabilization via post-segregational killing of the bacterial host. The genes encoding TA systems also exist on bacterial chromosomes, and it has been speculated that these are involved in a variety of cellular processes.
Julia J, Williams, Paul J, Hergenrother
openaire   +2 more sources

Toxin-antitoxin Systems: Classification, Biological Function and Application in Biotechnology

, 2014
The toxin-antitoxin (TA) systems are systems in which an unstable antitoxin inhibits a stable toxin. This review aims to introduce the TA system and its biological application in bacteria.
Raftari, M., Sekawi, Z., Sadeghifard, N., Ghafourian, S.   +3 more
core   +1 more source