Toxin–antitoxin systems and regulatory mechanisms in Mycobacterium tuberculosis [PDF]
Pathogens and Disease, 2018 There has been a significant reduction in annual tuberculosis incidence since the World Health Organization declared tuberculosis a global health threat. However, treatment of M. tuberculosis infections requires lengthy multidrug therapeutic regimens to achieve a durable cure.
Richard A, Slayden +2 more
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Automated discovery and phylogenetic analysis of new toxin-antitoxin systems. [PDF]
, 2008 Although often viewed as elements "at the service of" bacteria, plasmids exhibit replication and maintenance mechanisms that make them purely "selfish DNA" candidates.
Michel C Milinkovitch +8 more
core +1 more source
AAU-Specific RNA Cleavage Mediated by MazF Toxin Endoribonuclease Conserved in Nitrosomonas europaea
Toxins, 2016 Nitrosomonas europaea carries numerous toxin-antitoxin systems. However, despite the abundant representation in its chromosome, studies have not surveyed the underlying molecular functions in detail, and their biological roles remain enigmatic.
Tatsuki Miyamoto +3 more
doaj +1 more source
Identification of the First Functional Toxin-Antitoxin System in Streptomyces
PLoS ONE, 2012 Toxin-antitoxin (TA) systems are widespread among the plasmids and genomes of bacteria and archaea. This work reports the first description of a functional TA system in Streptomyces that is identical in two species routinely used in the laboratory: Streptomyces lividans and S. coelicolor.
Sevillano, Laura +4 more
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Type II toxin: antitoxin systems. More than small selfish entities? [PDF]
, 2016 Toxin-antitoxin (TA) modules regulate metabolism and viability of bacteria and archaea. In type II TA systems these functions are generally thought to be performed by two small proteins.
Rocker, A., Meinhart, A.
core +1 more source
Frontiers in Microbiology, 2018 The search for new, non-standard targets is currently a high priority in the design of new antibacterial compounds. Bacterial toxin–antitoxin systems (TAs) are genetic modules that encode a toxin protein that causes growth arrest by interfering with ...
Marcin Równicki +9 more
doaj +1 more source
Toxin-Antitoxin Systems in the Mobile Genome of Acidithiobacillus ferrooxidans
PLoS ONE, 2014 Toxin-antitoxin (TA) systems are genetic modules composed of a pair of genes encoding a stable toxin and an unstable antitoxin that inhibits toxin activity. They are widespread among plasmids and chromosomes of bacteria and archaea. TA systems are known to be involved in the stabilization of plasmids but there is no consensus about the function of ...
Bustamante, Paula +2 more
openaire +7 more sources
Toxin-antitoxin Systems: Classification, Biological Function and Application in Biotechnology [PDF]
, 2014 The toxin-antitoxin (TA) systems are systems in which an unstable antitoxin inhibits a stable toxin. This review aims to introduce the TA system and its biological application in bacteria.
Raftari, M. +3 more
core
Proteic toxin-antitoxin, bacterial plasmid addiction systems and their evolution with special reference to the pas system of pTF-FC2 [PDF]
, 1999 Genes encoding toxin-antitoxin proteins are frequently found on plasmids where they serve to stabilize the plasmid within a bacterial population. The toxin-antitoxin proteins do not increase the likelihood of a progeny cell receiving a plasmid but rather
Rawlings D.E.
core +1 more source
Generation of a toxin/antitoxin-based counterselection marker for Chlamydia trachomatis
Infection and ImmunityChlamydia trachomatis is the leading cause of bacterial sexually transmitted infection in the United States. The high rate of asymptomatic cases and absence of a vaccine often leave infections untreated, increasing the risk of serious complications in ...
Eleanor Steiner +3 more
doaj +1 more source