Results 101 to 110 of about 18,051 (202)

parD toxin–antitoxin system of plasmid R1 – basic contributions, biotechnological applications and relationships with closely‐related toxin–antitoxin systems [PDF]

The FEBS Journal, 2010
Toxin–antitoxin systems, as found in bacterial plasmids and their host chromosomes, play a role in the maintenance of genetic information, as well as in the response to stress. We describe the basic biology of the parD/kiskid toxin–antitoxin system of Escherichia coli plasmid R1, with an emphasis on regulation, toxin activity, potential applications in
Diago-Navarro, E., Hernandez-Arriaga, A.M., López-Villarejo, J., Muñoz-Gómez, A.J., Kamphuis, M.B., Boelens, R., Lemonnier, M., Díaz-Orejas, R.   +7 more
openaire   +4 more sources

The VapBC-4 Characterization Indicates It Is a Bona Fide Toxin-Antitoxin Module of Leptospira interrogans: Initial Evidence for a Role in Bacterial Adaptation

Microorganisms
Toxin-antitoxin (TA) systems are one of the bacterial adaptation mechanisms to adverse conditions. Leptospira interrogans serovar Copenhageni contains nine putative TA systems.
Bruna Oliveira Pigatto Azevedo, Deborah Kohn Damiano, Aline Florencio Teixeira, Ana Lucia Tabet Oller Nascimento, Luis Guilherme Virgilio Fernandes, Alexandre Paulo Yague Lopes   +5 more
doaj   +1 more source

Redefining Therapies for Drug‐Resistant Tuberculosis: Synergistic Effects of Antimicrobial Peptides, Nanotechnology, and Computational Design

Advanced Healthcare Materials, Volume 15, Issue 14, 10 April 2026.
Antimicrobial peptide (AMP)‐loaded nanocarriers provide a multifunctional strategy to combat drug‐resistant Mycobacterium tuberculosis. By enhancing intracellular delivery, bypassing efflux pumps, and disrupting bacterial membranes, this platform restores phagolysosome fusion and macrophage function.
Christian S. Carnero Canales, Jessica Ingrid Marquez Cazorla, Renzo Marianito Marquez Cazorla, Aline Martins dos Santos, Jonatas Lobato Duarte, Letícia Oliveira Catarin Nunes, Túlio Custódio Reis, Lara Cerazi Salvador, Norival Alves Santos‐Filho, Rafael Miguel Sábio, Hélder A. Santos, Fernando Rogério Pavan   +11 more
wiley   +1 more source

AAU-Specific RNA Cleavage Mediated by MazF Toxin Endoribonuclease Conserved in Nitrosomonas europaea

Toxins, 2016
Nitrosomonas europaea carries numerous toxin-antitoxin systems. However, despite the abundant representation in its chromosome, studies have not surveyed the underlying molecular functions in detail, and their biological roles remain enigmatic.
Tatsuki Miyamoto, Akiko Yokota, Satoshi Tsuneda, Naohiro Noda   +3 more
doaj   +1 more source

RHS-elements function as type II toxin-antitoxin modules that regulate intra-macrophage replication of Salmonella Typhimurium.

PLoS Genetics, 2020
RHS elements are components of conserved toxin-delivery systems, wide-spread within the bacterial kingdom and some of the most positively selected genes known. However, very little is known about how Rhs toxins affect bacterial biology.
Magnus Stårsta, Disa L Hammarlöf, Marcus Wäneskog, Susan Schlegel, Feifei Xu, Arvid Heden Gynnå, Malin Borg, Sten Herschend, Sanna Koskiniemi   +8 more
doaj   +1 more source

Biopharmaceuticals for Cancer Treatment: An Update

Cancer Medicine, Volume 15, Issue 4, April 2026.
ABSTRACT Cancer is one of the most debilitating diseases, causing profound physical and psychological impacts on patients. The global number of cancer patients has been steadily rising over the last few decades. The development of effective cancer therapies remains the primary focus in life science research, requiring a precise understanding of ...
Anupom Deb Nath, Yousuf Alam, Afsana Mustak Mim, Maksuda Akter, Mohammad Abbas Gani, Khondaker Muhammad Khairul Alam, Md. Nur Alam   +6 more
wiley   +1 more source

Artificial Activation of Escherichia coli mazEF and hipBA Toxin–Antitoxin Systems by Antisense Peptide Nucleic Acids as an Antibacterial Strategy

Frontiers in Microbiology, 2018
The search for new, non-standard targets is currently a high priority in the design of new antibacterial compounds. Bacterial toxin–antitoxin systems (TAs) are genetic modules that encode a toxin protein that causes growth arrest by interfering with ...
Marcin Równicki, Marcin Równicki, Tomasz Pieńko, Tomasz Pieńko, Jakub Czarnecki, Jakub Czarnecki, Monika Kolanowska, Monika Kolanowska, Dariusz Bartosik, Joanna Trylska   +9 more
doaj   +1 more source

Resonant activation: a strategy against bacterial persistence

, 2010
A bacterial colony may develop a small number of cells genetically identical to, but phenotypically different from other normally growing bacteria. These so-called persister cells keep themselves in a dormant state and thus are insensitive to antibiotic ...
Hanggi P, Jianhua Xing, Meng Zhu, Schmitt C, Yan Fu   +4 more
core   +1 more source

Molecular bases and role of viruses in the human microbiome. [PDF]

, 2014
Viruses are dependent biological entities that interact with the genetic material of most cells on the planet, including the trillions within the human microbiome.
Abeles, Shira R, Pride, David T
core   +1 more source

Insecticide@Silica Nanocontainers with High Cypermethrin Load and Improved Photostability

ChemNanoMat, Volume 12, Issue 4, April 2026.
Cypermethrin@Octylsilicate core@shell nanocontainers (total diameter: 34 nm, diameter of cypermethrin core: 15 nm) exhibit high colloidal stability in water and high photochemical stability of the insecticide, allowing to reduce reapplication cycles and, thus, time and costs of insecticide application.
Mark Rutschmann, Jasmin Mokinski, Claus Feldmann   +2 more
wiley   +1 more source