Results 101 to 110 of about 9,494,692 (194)

Type II Toxin-Antitoxin Systems in Escherichia coli [PDF]

He Zhang,1 Shuan Tao,2 Huimin Chen,2 Yewei Fang,2 Yao Xu,3 A-Xiang Han,2 Fang Ma,1,* Wei Liang2,* 1Department of Medical Laboratory, Bengbu Medical University, Bengbu, Anhui, People’s Republic of China; 2Department of Clinical Laboratory, The ...
Fang Y, Han AX, Liang W, Zhang H, Tao S, Chen H, Ma F, Xu Y   +7 more
core  

AAU-Specific RNA Cleavage Mediated by MazF Toxin Endoribonuclease Conserved in Nitrosomonas europaea

Toxins, 2016
Nitrosomonas europaea carries numerous toxin-antitoxin systems. However, despite the abundant representation in its chromosome, studies have not surveyed the underlying molecular functions in detail, and their biological roles remain enigmatic.
Tatsuki Miyamoto, Akiko Yokota, Satoshi Tsuneda, Naohiro Noda   +3 more
doaj   +1 more source

Polyphenol‐Based Biomaterials for Antibacterial Infection Management: From Assembly Chemistry to Infection Site‐Specific Therapeutic Platforms

cMat, Volume 3, Issue 3, September 2026.
Polyphenol assembly chemistry provides a versatile basis for antibacterial biomaterials. Matching material format and function to the distinct barriers of wound, respiratory, intestinal, and implant‐associated infections is central to effective and translatable design. ABSTRACT Bacterial infections involving multidrug‐resistant pathogens and persistent
Wei Yang, Li Wan, Ming Wen, Haiyan He, Hongliang Tan   +4 more
wiley   +1 more source

Identification of the First Functional Toxin-Antitoxin System in Streptomyces

PLoS ONE, 2012
Toxin-antitoxin (TA) systems are widespread among the plasmids and genomes of bacteria and archaea. This work reports the first description of a functional TA system in Streptomyces that is identical in two species routinely used in the laboratory: Streptomyces lividans and S. coelicolor.
Sevillano, Laura, Díaz, Margarita, Yamaguchi, Y., Inouye, M., Santamaría, Ramón I.   +4 more
openaire   +5 more sources

Artificial Activation of Escherichia coli mazEF and hipBA Toxin–Antitoxin Systems by Antisense Peptide Nucleic Acids as an Antibacterial Strategy

Frontiers in Microbiology, 2018
The search for new, non-standard targets is currently a high priority in the design of new antibacterial compounds. Bacterial toxin–antitoxin systems (TAs) are genetic modules that encode a toxin protein that causes growth arrest by interfering with ...
Marcin Równicki, Marcin Równicki, Tomasz Pieńko, Tomasz Pieńko, Jakub Czarnecki, Jakub Czarnecki, Monika Kolanowska, Monika Kolanowska, Dariusz Bartosik, Joanna Trylska   +9 more
doaj   +1 more source

Engineering Bacteria for Medicine: Delivery, Diagnosis, and Therapy

iMetaMed, Volume 2, Issue 3, September 2026.
ABSTRACT With rapid advances in synthetic biology and genetic engineering, genetically engineered bacteria (GEB) have emerged as a promising platform for biological therapy, addressing key limitations of conventional drug delivery systems and demonstrating significant clinical potential.
Shiyu Xia, Guiling Fu, Xiaoyue Ding, Wen Yang, Ruijie Bai, Yawei Cai, Jing xuan Zhang, Yanxia Wei, Conghui Han, Yi‐Zhou Gao, Ying Li, Zuobin Zhu   +11 more
wiley   +1 more source

Wake Me When It\u27s Over- Bacterial Toxin-Antitoxin Proteins and Induced Dormancy [PDF]

, 2016
Toxin-antitoxin systems are encoded by bacteria and archaea to enable an immediate response to environmental stresses, including antibiotics and the host immune response.
Daines, Dayle A., Coussens, Nathan P.
core   +1 more source

Identification, functional characterization, assembly and structure of ToxIN type III toxin antitoxin complex from E. coli

, 2022
Toxin antitoxin TA systems are proposed to play crucial roles in bacterial growth under stress conditions such as phage infection. The type III TA systems consist of a protein toxin whose activity is inhibited by a noncoding RNA antitoxin. The toxin is
Paul, S., Srinivasan, N., Nadig, K., Singh, M., Rothweiler, U., Manikandan, P., Sandhya, S., Parthasarathy Manikandan, Ulli Rothweiler, Kavyashree Nadig, Mahavir Singh, Souradip Paul, Narayanaswamy Srinivasan, Sankaran Sandhya   +13 more
core   +1 more source

Generation of a toxin/antitoxin-based counterselection marker for Chlamydia trachomatis

Infection and Immunity
Chlamydia trachomatis is the leading cause of bacterial sexually transmitted infection in the United States. The high rate of asymptomatic cases and absence of a vaccine often leave infections untreated, increasing the risk of serious complications in ...
Eleanor Steiner, Samantha D’Spain, Rachel Ende, Isabelle Derré   +3 more
doaj   +1 more source

Type II toxin: antitoxin systems. More than small selfish entities?

, 2016
Toxin-antitoxin (TA) modules regulate metabolism and viability of bacteria and archaea. In type II TA systems these functions are generally thought to be performed by two small proteins.
Rocker, A., Meinhart, A.
core   +1 more source