Results 101 to 110 of about 16,346 (193)

Generation of a toxin/antitoxin-based counterselection marker for Chlamydia trachomatis

Infection and Immunity
Chlamydia trachomatis is the leading cause of bacterial sexually transmitted infection in the United States. The high rate of asymptomatic cases and absence of a vaccine often leave infections untreated, increasing the risk of serious complications in ...
Eleanor Steiner, Samantha D’Spain, Rachel Ende, Isabelle Derré   +3 more
doaj   +1 more source

Toxin-antitoxin genes are differentially expressed in Escherichia coli relA and spoT mutans cultured under nitrogen, fatty acid, or carbon starvation conditions

Frontiers in Microbiology
IntroductionThe stringent response is one of the fundamental mechanisms that control and modulate bacterial adaptation to stress conditions, such as nutrient limitation.
Monika Maciąg-Dorszyńska, Paweł Olszewski, Monika Karczewska, Lidia Boss   +3 more
doaj   +1 more source

Orphan Toxin OrtT (YdcX) of Escherichia coli Reduces Growth during the Stringent Response

Toxins, 2015
Toxin/antitoxin (TA) systems are nearly universal in prokaryotes; toxins are paired with antitoxins which inactivate them until the toxins are utilized. Here we explore whether toxins may function alone; i.e., whether a toxin which lacks a corresponding ...
Sabina Islam, Michael J. Benedik, Thomas K. Wood   +2 more
doaj   +1 more source

Time to Diagnosis and Persistence: The Two Major Determinants of Effective Tuberculosis Control

, 2015
The greatest challenge confronting effective tuberculosis (TB) eradication is the time to diagnosis, and duration of treatment of chronically infected individuals which represent a pool of infection.
Ruthe, Alaine Tess
core  

Toxin-antitoxin systems predicted in L. pentosus KCA1.

, 2013
Toxin-antitoxin systems predicted in L. pentosus KCA1.
Bernadet Renckens (391864), Kingsley C. Anukam (391863), Jos Boekhorst (81341), Jean M. Macklaim (198176), Gregory B. Gloor (198199), Gregor Reid (163342), Roland J. Siezen (12053), Sacha A. F. T. van Hijum (9843)   +7 more
core   +1 more source

The Biology and Biochemistry of PhoH2 proteins

, 2013
PhoH2 proteins are found in a diverse range of organisms. To date little is known about these proteins and the role they play in the organisms in which they reside.
Andrews, Emma Sophie Vout
core  

Bioinformatics and Functional Assessment of Toxin-Antitoxin Systems in Staphylococcus aureus

Toxins, 2018
Staphylococcus aureus is a nosocomial pathogen that can cause chronic to persistent infections. Among different mediators of pathogenesis, toxin-antitoxin (TA) systems are emerging as the most prominent.
Gul Habib, Qing Zhu, Baolin Sun
doaj   +1 more source

Algal blooms as biofilm analogues: Evolutionary insights into cyanobacterial adaptation

Limnology and Oceanography Letters, Volume 11, Issue 3, May 2026.
Hidetoshi Urakawa, Hans W. Paerl
wiley   +1 more source

de novo synthesis of a bacterial toxin/antitoxin system [PDF]

, 2014
The prevalence of toxin/antitoxin (TA) systems in almost all genomes suggests they evolve rapidly. Here we show that an antitoxin from a type V system (GhoS, an endoribonuclease specific for the mRNA of the toxin GhoT) can be converted into a novel toxin
Soo, Valerie WC, Cheng, Hsin-Yao, Wood, Thomas K, Kwan, Brian W   +3 more
core   +1 more source

Identification, characterization, structure, and assembly of type III toxin-antitoxin systems from Escherichia coli

, 2021
Bacteria adopt several defense strategies to enable their survival against the environmental threats they encounter from time to time. Toxin-antitoxin (TA) systems are being understood as a key bacterial defense mechanism against invading viruses ...
Manikandan, P
core