Results 111 to 120 of about 9,494,692 (194)

Orphan Toxin OrtT (YdcX) of Escherichia coli Reduces Growth during the Stringent Response

Toxins, 2015
Toxin/antitoxin (TA) systems are nearly universal in prokaryotes; toxins are paired with antitoxins which inactivate them until the toxins are utilized. Here we explore whether toxins may function alone; i.e., whether a toxin which lacks a corresponding ...
Sabina Islam, Michael J. Benedik, Thomas K. Wood   +2 more
doaj   +1 more source

Identification of Three Type II Toxin-Antitoxin Systems in Model Bacterial Plant Pathogen Dickeya dadantii 3937

, 2021
Type II toxin-antitoxin (TA) systems are genetic elements usually encoding two proteins: a stable toxin and an antitoxin, which binds the toxin and neutralizes its toxic effect.
Joanna Morcinek-Orłowska, Lidia Boss, Sylwia Barańska, Marcin Górniak, Agnieszka Szalewska-Pałasz, Alicja Lewańczyk   +5 more
core   +1 more source

Toxin-antitoxin genes are differentially expressed in Escherichia coli relA and spoT mutans cultured under nitrogen, fatty acid, or carbon starvation conditions

Frontiers in Microbiology
IntroductionThe stringent response is one of the fundamental mechanisms that control and modulate bacterial adaptation to stress conditions, such as nutrient limitation.
Monika Maciąg-Dorszyńska, Paweł Olszewski, Monika Karczewska, Lidia Boss   +3 more
doaj   +1 more source

Time to Diagnosis and Persistence: The Two Major Determinants of Effective Tuberculosis Control [PDF]

, 2015
The greatest challenge confronting effective tuberculosis (TB) eradication is the time to diagnosis, and duration of treatment of chronically infected individuals which represent a pool of infection.
Ruthe, Alaine Tess
core  

Toxin-antitoxin systems and its biotechnological applications

, 2014
Toxin-antitoxin (TA) systems are important genetic modules composed by two elements: a toxin, that is always a protein, and an antitoxin, that can be a RNA or a protein and neutralizes the toxic effect of toxin.
Cangussu, Alex Sânder Rodrigues, Garrido, Saulo Santesso [UNESP], Marchetto, Reinaldo [UNESP], Garrido, Saulo Santesso, Barbosa, Luiz Carlos Bertucci, Marchetto, Reinaldo   +5 more
core   +1 more source

Bioinformatics and Functional Assessment of Toxin-Antitoxin Systems in Staphylococcus aureus

Toxins, 2018
Staphylococcus aureus is a nosocomial pathogen that can cause chronic to persistent infections. Among different mediators of pathogenesis, toxin-antitoxin (TA) systems are emerging as the most prominent.
Gul Habib, Qing Zhu, Baolin Sun
doaj   +1 more source

prlF and yhaV encode a new toxin-antitoxin system in Escherichia coli

, 2007
Toxin-antitoxin systems consist of a stable toxin, frequently with endonuclease activity, and a small, labile antitoxin, which sequesters the toxin into an inactive complex.
Lupas, A. ; https://orcid.org/, Djuranovic, S., Schuenemann, V., Schmidt, O., Silhavy, T., Hand, N., Martin, J. ; https://orcid.org/   +6 more
core   +1 more source

A common origin for the bacterial toxin-antitoxin systems parD and ccd, suggested by analyses of toxin/target and toxin/antitoxin interactions.

, 2012
Bacterial toxin-antitoxin (TA) systems encode two proteins, a potent inhibitor of cell proliferation (toxin) and its specific antidote (antitoxin). Structural data has revealed striking similarities between the two model TA toxins CcdB, a DNA gyrase ...
Albert J. Heck (132176), Lesley A. Mitchenall (132174), Ramón Díaz-Orejas, Elizabeth Diago-Navarro (132173), Arjan Barendregt, Marc Lemonnier, Anthony Maxwell, Anthony Maxwell (9506), Andrew B Smith, Juan López-Villarejo (28543), Lesley A Mitchenall, Arjan Barendregt (132175), Elizabeth Diago-Navarro, Ramón Díaz-Orejas (28544), Albert J Heck, Marc Lemonnier (132177), Andrew B. Smith (132171), Juan López-Villarejo   +17 more
core   +1 more source

A simple BLASTn-based approach generates novel insights into the regulation and biological function of type I toxin-antitoxins

mSystems
Bacterial chromosomal type I toxin-antitoxin systems consist of a small protein, typically under 60 amino acids, and a small RNA (sRNA) that represses toxin translation.
Selene F. H. Shore, Michael Ptacek, Andrew D. Steen, Elizabeth M. Fozo   +3 more
doaj   +1 more source

Excitable dynamics through toxin-induced mRNA cleavage in bacteria.

PLoS ONE, 2019
Toxin-antitoxin (TA) systems in bacteria and archaea are small genetic elements consisting of the genes coding for an intracellular toxin and an antitoxin that can neutralize this toxin. In various cases, the toxins cleave the mRNA.
Stefan Vet, Alexandra Vandervelde, Lendert Gelens   +2 more
doaj   +1 more source