Results 91 to 100 of about 16,346 (193)

Protein design and RNA design: Perspectives

Quantitative Biology, Volume 14, Issue 2, June 2026.
Abstract Advances in deep learning and generative modeling have transformed the landscape of protein and RNA design, enabling rapid and precise creation of novel biomolecules with tailored structures and functions. In protein design, generative deep learning frameworks now support backbone generation, sequence optimization, and joint sequence–structure
Xi Chen, Xu Dai, Peilong Lu
wiley   +1 more source

AAU-Specific RNA Cleavage Mediated by MazF Toxin Endoribonuclease Conserved in Nitrosomonas europaea

Toxins, 2016
Nitrosomonas europaea carries numerous toxin-antitoxin systems. However, despite the abundant representation in its chromosome, studies have not surveyed the underlying molecular functions in detail, and their biological roles remain enigmatic.
Tatsuki Miyamoto, Akiko Yokota, Satoshi Tsuneda, Naohiro Noda   +3 more
doaj   +1 more source

Adverse Drug Reaction Study of Botulinum Toxin‐A in the Real World

Journal of Cosmetic Dermatology, Volume 25, Issue 6, June 2026.
ABSTRACT Background Despite the increasing use of botulinum toxin type A (BoNT‐A) in aesthetic and therapeutic applications, its real‐world adverse drug reaction (ADR) profile remains incompletely characterized. Current evidence relies largely on small‐scale clinical observations rather than large, systematic analyses.
Jiaxu Gu, Yue Sun, Kexin Chen, Jieyi Wang, Bingcheng Lu, Hongqiang Xie, Xiaoming Liu, Cong Huang, Xingling Jian, Bo Yu   +9 more
wiley   +1 more source

Toxin-Antitoxin Systems in the Mobile Genome of Acidithiobacillus ferrooxidans

PLoS ONE, 2014
Toxin-antitoxin (TA) systems are genetic modules composed of a pair of genes encoding a stable toxin and an unstable antitoxin that inhibits toxin activity. They are widespread among plasmids and chromosomes of bacteria and archaea. TA systems are known to be involved in the stabilization of plasmids but there is no consensus about the function of ...
Bustamante, Paula, Tello, Mario, Orellana, Omar   +2 more
openaire   +7 more sources

Artificial Activation of Escherichia coli mazEF and hipBA Toxin–Antitoxin Systems by Antisense Peptide Nucleic Acids as an Antibacterial Strategy

Frontiers in Microbiology, 2018
The search for new, non-standard targets is currently a high priority in the design of new antibacterial compounds. Bacterial toxin–antitoxin systems (TAs) are genetic modules that encode a toxin protein that causes growth arrest by interfering with ...
Marcin Równicki, Marcin Równicki, Tomasz Pieńko, Tomasz Pieńko, Jakub Czarnecki, Jakub Czarnecki, Monika Kolanowska, Monika Kolanowska, Dariusz Bartosik, Joanna Trylska   +9 more
doaj   +1 more source

Turmeric and curcumin: From traditional medicine to modern therapeutic applications

JSFA reports, Volume 6, Issue 5, Page 160-178, May 2026.
Abstract Turmeric (Curcuma longa), a medicinal plant, has maintained its cultural and therapeutic significance over centuries in Ayurveda, Unani, and Traditional Chinese Medicine. However, novel formulations and delivery methods are being developed to address these challenges.
Azma Nadeem, Khurram Afzal, Asad Abbas, Talha Bin Iqbal, Abdul Malik, Javaria Saeed, Mutjardah Zarrish, Bipindra Pandey   +7 more
wiley   +1 more source

Characterisation of VapBC Toxin-Antitoxins from Mycobacterium tuberculosis

, 2013
Toxin-antitoxin (TA) systems were identified more than 20 years ago on the mini F plasmid of Escherichia coli as plasmid stability elements; components responsible for purging bacterial cells that lack the plasmid from the population.
Sharrock, Abigail Victoria
core  

Identification, functional characterization, assembly and structure of ToxIN type III toxin antitoxin complex from E. coli

, 2022
Toxin antitoxin TA systems are proposed to play crucial roles in bacterial growth under stress conditions such as phage infection. The type III TA systems consist of a protein toxin whose activity is inhibited by a noncoding RNA antitoxin. The toxin is
Paul, S., Srinivasan, N., Nadig, K., Singh, M., Rothweiler, U., Manikandan, P., Sandhya, S.   +6 more
core   +1 more source

T3SS effector and regulator discovery by predicting interacting partners of T3SS chaperones in Pseudomonas aeruginosa

Protein Science, Volume 35, Issue 5, May 2026.
Abstract Pseudomonas aeruginosa is a prominent opportunistic pathogen whose virulence is closely linked to its Type III Secretion System (T3SS), a specialized apparatus that injects effector proteins into host cells. T3SS chaperones are essential for stabilizing, delivering, and regulating T3SS expression.
Jing Zhang
wiley   +1 more source

The Biochemistry of VapBC Toxin-Antitoxins

, 2011
The VapBC toxin-antitoxin (TA) systems were first identified in 2005 and little is known about their contemporary biological function, despite the fact that VapBC TAs are the largest TA family and are widespread in bacteria and archaea (Arcus, Rainey ...
McKenzie, Joanna Leigh
core