Results 61 to 70 of about 9,494,692 (194)
Toxin-Antitoxin Systems: Classification, Biological Function and Application in Biotechnology
, 2013 The toxin-antitoxin (TA) systems are systems in which an unstable antitoxin inhibits a stable toxin. This review aims to introduce the TA system and its biological application in bacteria. For this purpose, first we introduce a new classification for the
Sobhan Ghafourian +3 more
core +1 more source
Automated discovery and phylogenetic analysis of new toxin-antitoxin systems. [PDF]
, 2008 Although often viewed as elements "at the service of" bacteria, plasmids exhibit replication and maintenance mechanisms that make them purely "selfish DNA" candidates.
Michel C Milinkovitch +8 more
core +1 more source
Bacterial retrons encode phage-sensing toxin/antitoxin systems [PDF]
, 2022 Retrons are prokaryotic genetic systems containing reverse transcriptases (RTs) that produce multiple copies of small single-stranded DNA (msDNA). Despite our understanding of the complex msDNA biosynthesis, the physiological role of retrons has ...
Bomponis, Iakovos
core +1 more source
BMC Genomics, 2006 Background Post-segregational killing systems are present in a large variety of microorganisms. When found on plasmids, they are described as addiction systems that act to maintain the plasmid during the partitioning of the cell.
Mahillon Jacques, Fico Sarah
doaj +1 more source
IUCrJ, 2022 Type II toxin–antitoxin (TA) systems encode two proteins: a toxin that inhibits cell growth and an antitoxin that neutralizes the toxin by direct intermolecular protein–protein interactions.
Ji Sung Koo +4 more
doaj +1 more source
Molecular Microbiology, EarlyView.Screening 72,555 plasmid sequences reveals that intact CRISPR‐Cas systems are rare (1.03%) but strongly enriched in multireplicon and multi‐stressor resistance plasmids, with Type IV‐A as the dominant subtype. These findings implicate plasmid‐encoded CRISPR‐Cas as non‐randomly retained elements of structurally complex and high‐risk backbones.
Hannay Crystynah Almeida de Souza +4 more
wiley +1 more source
The Bacillus cereus spoIIS programmed cell death system
Frontiers in Microbiology, 2015 Programmed cell death in bacteria is generally associated with two¬ component toxin antitoxin systems. The SpoIIS toxin-antitoxin system, consisting of a membrane bound SpoIISA toxin and a small, cytosolic antitoxin SpoIISB, was originally identified in ...
Jana eMelnicakova +3 more
doaj +1 more source
Periodontology 2000, EarlyView.Abstract Background/Aim Growing evidence suggests that imbalances occurring within the human microbiota and deregulation of the host immune response may play a significant role in the development of neurodegenerative diseases. Materials and Methods A comprehensive narrative review of the latest experimental, clinical, and epidemiological insights was ...
Emilio A. Cafferata +3 more
wiley +1 more source
The Biochemistry of VapBC Toxin-Antitoxins [PDF]
, 2011 The VapBC toxin-antitoxin (TA) systems were first identified in 2005 and little is known about their contemporary biological function, despite the fact that VapBC TAs are the largest TA family and are widespread in bacteria and archaea (Arcus, Rainey ...
McKenzie, Joanna Leigh
core
TASmania: A bacterial Toxin-Antitoxin Systems database
PLOS Computational Biology, 2019 Bacterial Toxin-Antitoxin systems (TAS) are involved in key biological functions including plasmid maintenance, defense against phages, persistence and virulence. They are found in nearly all phyla and classified into 6 different types based on the mode of inactivation of the toxin, with the type II TAS being the best characterized so far.
Hatice Akarsu +5 more
openaire +6 more sources