Results 41 to 50 of about 16,375 (172)

Prevalence of Fst-like toxin–antitoxin systems [PDF]

Microbiology, 2010
Toxin–antitoxin (TA) systems are widespread in Gram-negative bacteria, and all systems identified to date encode a toxic protein and an unstable antitoxin, which may be in the form of either an antisense RNA (type I) or a second protein (type II). The enterococcal plasmid pAD1-encoded TA system (par), encoding the Fst toxin, was the first type I TA ...
Kwong, Stephen M. (R20881), Jensen, Slade O., Firth, Neville   +2 more
openaire   +3 more sources

Adenylylation of Gyrase and Topo IV by FicT Toxins Disrupts Bacterial DNA Topology [PDF]

, 2015
Toxin-antitoxin (TA) modules are ubiquitous molecular switches controlling bacterial growth via the release of toxins that inhibit cell proliferation.
Gerdes, K., Glatter, Timo, Dehio, Christoph, Alexander Harms, Goepfert, A., Scheu, P., Kenn Gerdes, Glatter, T. ; https://orcid.org/, Schirmer, T., Harms, Alexander, Christoph Dehio, Harms, A., Timo Glatter, Stanger, Frédéric Valentin, Gerdes, Kenn, Dehio, C., Schirmer, Tilman, Harms, Alexander; id_orcid, de Jong, I., de Jong, Imke Greet, Stanger, F., Tilman Schirmer, Patrick Daniel Scheu, Arnaud Goepfert, Scheu, Patrick Daniel, Frédéric Valentin Stanger, Imke Greet de Jong, Goepfert, Arnaud   +27 more
core   +1 more source

Reassessing the Role of the Type II MqsRA Toxin-Antitoxin System in Stress Response and Biofilm Formation: mqsA Is Transcriptionally Uncoupled from mqsR

mBio, 2019
Toxin-antitoxin (TA) systems are broadly distributed modules whose biological roles remain mostly unknown. The mqsRA system is a noncanonical TA system in which the toxin and antitoxins genes are organized in operon but with the particularity that the ...
Nathan Fraikin, Clothilde J. Rousseau, Nathalie Goeders, Laurence Van Melderen   +3 more
doaj   +1 more source

Stress induces the transcription of toxin-antitoxin systems but does not activate toxin [PDF]

, 2021
Data corresponding to manuscript entitled "Stress induces the transcription of toxin-antitoxin systems but does not activate ...
LeRoux, M (via Mendeley Data)
core   +1 more source

The Cysteine Protease MaOC1, a Prokaryotic Caspase Homolog, Cleaves the Antitoxin of a Type II Toxin-Antitoxin System

Frontiers in Microbiology, 2021
The bloom-forming cyanobacterium Microcystis aeruginosa is known for its global distribution and for the production of toxic compounds. In the genome of M.
Marina Klemenčič, Ana Halužan Vasle, Marko Dolinar   +2 more
doaj   +1 more source

Type II Toxin-Antitoxin Systems in Escherichia coli. [PDF]

Infect Drug Resist
The toxin-antitoxin (TA) system is widespread in prokaryotes and archaea, comprising toxins and antitoxins that counterbalance each other. Based on the nature and mode of action of antitoxins, they are classified into eight groups (type I to VIII). Both the toxins and the antitoxins are proteins in type II TA systems, and the antitoxin gene is usually ...
Zhang H, Tao S, Chen H, Fang Y, Xu Y, Han AX, Ma F, Liang W.   +7 more
europepmc   +5 more sources

Toxin-Antitoxin Systems and Persistence

, 2019
Toxin-antitoxin (TA) systems are small genetic modules comprising a stable toxic protein and an antitoxin preventing the toxin activity. In type II TA systems, antitoxins are unstable proteins that are degraded by host ATP-dependent proteases. In steady-state conditions, the antitoxin forms a complex with the toxin in which the toxic activity is ...
Fraikin, Nathan, Goormaghtigh, Frederic, Van Melderen, Laurence   +2 more
openaire   +2 more sources

The Toxin-Antitoxin System of the Streptococcal Plasmid pSM19035 [PDF]

Journal of Bacteriology, 2005
ABSTRACT pSM19035 of the pathogenic bacterium Streptococcus pyogenes is a low-copy-number plasmid carrying erythromycin resistance, stably maintained in a broad range of gram-positive bacteria. We show here that the ω -ε-ζ operon of this plasmid constitutes a novel proteic plasmid ...
Urszula, Zielenkiewicz, Piotr, Ceglowski
openaire   +2 more sources

Multiple Toxin-Antitoxin Systems in Mycobacterium tuberculosis [PDF]

Toxins, 2014
The hallmark of Mycobacterium tuberculosis is its ability to persist for a long-term in host granulomas, in a non-replicating and drug-tolerant state, and later awaken to cause disease. To date, the cellular factors and the molecular mechanisms that mediate entry into the persistence phase are poorly understood. Remarkably, M.
Ambre Sala, Patricia Bordes, Pierre Genevaux   +2 more
openaire   +3 more sources

Characterization of HicAB toxin-antitoxin module of Sinorhizobium meliloti

BMC Microbiology, 2019
Background Toxin-antitoxin (TA) systems are little genetic units generally composed of two genes encoding antitoxin and toxin. These systems are known to be involved in many functions that can lead to growth arrest and cell death.
Manon Thomet, Annie Trautwetter, Gwennola Ermel, Carlos Blanco   +3 more
doaj   +1 more source