Results 21 to 30 of about 18,051 (202)
Toxin-antitoxin systems in bacterial pathogenesis. [PDF]
Heliyon, 2023 Toxin-Antitoxin (TA) systems are abundant in prokaryotes and play an important role in various biological processes such as plasmid maintenance, phage inhibition, stress response, biofilm formation, and dormant persister cell generation. TA loci are abundant in pathogenic intracellular micro-organisms and help in their adaptation to the harsh host ...
Sonika S, Singh S, Mishra S, Verma S.
europepmc +4 more sources
mBio, 2021 Bacterial toxin-antitoxin (TA) systems encode a toxin and an antitoxin that counteracts the toxin. Such TA systems are found abundantly on bacterial chromosomes and on extrachromosomal genetic elements. The toxin is always a protein.
Alexander Mager +2 more
doaj +1 more source
Bacterial retrons encode phage-defending tripartite toxin-antitoxin systems. [PDF]
Nature, 2022 Bobonis J +19 more
europepmc +2 more sources
Bacterial toxin-antitoxin systems [PDF]
Mobile Genetic Elements, 2011 Toxin-antitoxin (TA) systems are composed of two elements: a toxic protein and an antitoxin which is either an RNA (type I and III) or a protein (type II). Type II systems are abundant in bacterial genomes in which they move via horizontal gene transfer.
Guglielmini, Julien +1 more
openaire +3 more sources
Toxin-Antitoxin Systems in Clinical Pathogens [PDF]
Toxins, 2016 Toxin-antitoxin (TA) systems are prevalent in bacteria and archaea. Although not essential for normal cell growth, TA systems are implicated in multiple cellular functions associated with survival under stress conditions. Clinical strains of bacteria are currently causing major human health problems as a result of their multidrug resistance ...
Laura Fernández-García +6 more
openaire +4 more sources
Nature Communications, 2023 Mycobacterium tuberculosis, the bacterium responsible for human tuberculosis, has a genome encoding a remarkably high number of toxin-antitoxin systems of largely unknown function. We have recently shown that the M.
Xibing Xu +9 more
doaj +1 more source
Frontiers in Genetics, 2021 Mycobacterium tuberculosis harbours nine toxin-antitoxin (TA) systems of the MazEF family. MazEF TA modules are of immense importance due to the perceived role of the MazF toxin in M. tuberculosis persistence and disease.
Soumyanetra Chandra +2 more
doaj +1 more source
Toxin–antitoxin systems: reversible toxicity
Current Opinion in Microbiology, 2017 Toxin-antitoxin (TA) systems encoded on the plasmids and chromosomes of bacteria are emerging as key players in stress adaptation. In particular, they have been implicated in the induction of persisters non-growing cells that can evade antibiotic exposure.
Hall, A, Gollan, B, Helaine, S
openaire +4 more sources
The vapB-vapC operon of Acidovorax citrulli functions as a bona-fide toxin-antitoxin module
Frontiers in Microbiology, 2016 Toxin–antitoxin systems are commonly found on plasmids and chromosomes of bacteria and archaea. These systems appear as biscystronic genes encoding a stable toxin and a labile antitoxin, which protects the cells from the toxin’s activity. Under specific,
Reut eShavit +4 more
doaj +1 more source
The coevolution of toxin and antitoxin genes drives the dynamics of bacterial addiction complexes and intragenomic conflict [PDF]
, 2012 Bacterial genomes commonly contain ‘addiction’ gene complexes that code for both a toxin and a corresponding antitoxin. As long as both genes are expressed, cells carrying the complex can remain healthy.
Brown, Sam P. +3 more
core +1 more source