Results 81 to 90 of about 4,806,779 (356)

Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer

Molecular Oncology, EarlyView.
We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas, Konstantinos Voutetakis, Vivian Kosmidou, Spyridon Tsikalakis, Spyridon Roditis, Konstantinos Pateas, Ryangguk Kim, Kymberleigh Pagel, Stephan Wolf, Gregor Warsow, Antonia Dimitrakopoulou‐Strauss, Georgios N. Zografos, Alexander Pintzas, Johannes Betge, Olga Papadodima, Stefan Wiemann   +15 more
wiley   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Time, the final frontier

Molecular Oncology, EarlyView.
This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain, Michal Dibus, Omkar Joshi, Guillaume Jacquemet   +3 more
wiley   +1 more source

Second-order boundary-value problems with variable exponents

Electronic Journal of Differential Equations, 2014
In this article, we study ordinary differential equations with p(x)-Laplacian and subject to small perturbations of nonhomogeneous Neumann conditions.
Giuseppina D'Agui
doaj  

Herz-Morrey-Hardy Spaces with Variable Exponents and Their Applications

Journal of Function Spaces, 2015
The authors introduce Herz-Morrey-Hardy spaces with variable exponents and establish the characterization of these spaces in terms of atom. Applying the characterization, the authors obtain the boundedness of some singular integral operators on these ...
Jingshi Xu, Xiaodi Yang
doaj   +1 more source

Blowup solutions and their blowup rates for parabolic equations with non-standard growth conditions

Electronic Journal of Qualitative Theory of Differential Equations, 2011
This paper concerns classical solutions for homogeneous Dirichlet problem of parabolic equations coupled via exponential sources involving variable exponents. We first establish blowup criteria for positive solutions.
Bingchen Liu, Fengjie Li
doaj   +1 more source

Infinitely many solutions to Kirchhoff double phase problems with variable exponents [PDF]

Applied Mathematics Letters, 2022
Ky Ho, Patrick Winkert
semanticscholar   +1 more source

Existence of weak solutions to a certain homogeneous parabolic Neumann problem involving variable exponents and cross-diffusion

Journal of Elliptic and Parabolic Equations, 2020
This paper deals with a homogeneous Neumann problem of a nonlinear diffusion system involving variable exponents dependent on spatial and time variables and cross-diffusion terms.
G. Arumugam, André H. Erhardt
semanticscholar   +1 more source

Enhancing transporter activity in heterologous expression systems with SAHA: a 2500‐times more potent and odorless alternative to butyrate

FEBS Open Bio, EarlyView.
Heterologous expression of membrane transporters in cultured cells is essential for functional characterization, but is sometimes limited by low activity. Our study compares the HDAC inhibitors butyrate, VPA and SAHA to enhance transport activity. We propose to replace butyrate by SAHA: it is equally effective, devoid of repulsive odor, costs less, and
Svenja Flögel, Maurice Tust, Samira Boussettaoui, Dietmar Fischer, Dirk Gründemann   +4 more
wiley   +1 more source

Nonlocal eigenvalue problems with variable exponent [PDF]

Moroccan Journal of Pure and Applied Analysis, 2018
Abstract We consider the nonlocal eigenvalue problem of the following form ( 𝒫 k )
Mohammed Shimi, Elhoussine Azroul
openaire   +3 more sources